Human Gene EIF1AY (ENST00000361365.7) Description and Page Index
  Description: Homo sapiens eukaryotic translation initiation factor 1A Y-linked (EIF1AY), transcript variant 1, mRNA. (from RefSeq NM_004681)
RefSeq Summary (NM_004681): This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gencode Transcript: ENST00000361365.7
Gencode Gene: ENSG00000198692.10
Transcript (Including UTRs)
   Position: hg38 chrY:20,575,776-20,593,154 Size: 17,379 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chrY:20,575,872-20,592,346 Size: 16,475 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrY:20,575,776-20,593,154)mRNA (may differ from genome)Protein (144 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 1A, Y-chromosomal; Short=eIF-1A Y isoform; AltName: Full=Eukaryotic translation initiation factor 4C; Short=eIF-4C;
FUNCTION: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).
INTERACTION: O60841:EIF5B; NbExp=2; IntAct=EBI-286439, EBI-928530;
SIMILARITY: Belongs to the eIF-1A family.
SIMILARITY: Contains 1 S1-like domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.86 RPKM in Heart - Left Ventricle
Total median expression: 238.35 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.3096-0.180 Picture PostScript Text
3' UTR -162.10808-0.201 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012340 - NA-bd_OB-fold
IPR016027 - NA-bd_OB-fold-like
IPR006196 - RNA-binding_domain_S1_IF1
IPR001253 - TIF_eIF-1A
IPR018104 - TIF_eIF-1A_CS

Pfam Domains:
PF01176 - Translation initiation factor 1A / IF-1

ModBase Predicted Comparative 3D Structure on O14602
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGD  WormBase 
Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding

Biological Process:
GO:0006412 translation
GO:0006413 translational initiation

-  Descriptions from all associated GenBank mRNAs
  AF000987 - Homo sapiens eIF-1A, Y isoform (EIF1AY) mRNA, complete cds.
DQ786267 - Homo sapiens clone HLS_IMAGE_305122 mRNA sequence.
BC005248 - Homo sapiens eukaryotic translation initiation factor 1A, Y-linked, mRNA (cDNA clone MGC:12282 IMAGE:3933718), complete cds.
DQ890576 - Synthetic construct clone IMAGE:100003206; FLH164080.01X; RZPDo839C06162D eukaryotic translation initiation factor 1A, Y-linked (EIF1AY) gene, encodes complete protein.
DQ893736 - Synthetic construct Homo sapiens clone IMAGE:100008196; FLH164076.01L; RZPDo839C06161D eukaryotic translation initiation factor 1A, Y-linked (EIF1AY) gene, encodes complete protein.
KJ892683 - Synthetic construct Homo sapiens clone ccsbBroadEn_02077 EIF1AY gene, encodes complete protein.
BT007201 - Homo sapiens eukaryotic translation initiation factor 1A, Y chromosome mRNA, complete cds.
JD070794 - Sequence 51818 from Patent EP1572962.
JD320729 - Sequence 301753 from Patent EP1572962.
AK127664 - Homo sapiens cDNA FLJ45762 fis, clone MESTC2000170.
JD419160 - Sequence 400184 from Patent EP1572962.
JD093517 - Sequence 74541 from Patent EP1572962.
JD327491 - Sequence 308515 from Patent EP1572962.
JD244299 - Sequence 225323 from Patent EP1572962.
JD564120 - Sequence 545144 from Patent EP1572962.
JD501651 - Sequence 482675 from Patent EP1572962.
JD044012 - Sequence 25036 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: IF1AY_HUMAN, NM_004681, O14602, Q9BS77, uc004fuk.1, uc004fuk.2, uc004fuk.3, uc004fuk.4, uc004fuk.5, uc004fuk.6
UCSC ID: uc004fuk.6
RefSeq Accession: NM_004681
Protein: O14602 (aka IF1AY_HUMAN or IF1Y_HUMAN)
CCDS: CCDS14795.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.