Human Gene EIF1AY (ENST00000361365.7) Description and Page Index
  Description: Homo sapiens eukaryotic translation initiation factor 1A Y-linked (EIF1AY), transcript variant 1, mRNA. (from RefSeq NM_004681)
RefSeq Summary (NM_004681): This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gencode Transcript: ENST00000361365.7
Gencode Gene: ENSG00000198692.10
Transcript (Including UTRs)
   Position: hg38 chrY:20,575,776-20,593,154 Size: 17,379 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chrY:20,575,872-20,592,346 Size: 16,475 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrY:20,575,776-20,593,154)mRNA (may differ from genome)Protein (144 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: IF1AY_HUMAN
DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 1A, Y-chromosomal; Short=eIF-1A Y isoform; AltName: Full=Eukaryotic translation initiation factor 4C; Short=eIF-4C;
FUNCTION: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).
INTERACTION: O60841:EIF5B; NbExp=2; IntAct=EBI-286439, EBI-928530;
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the eIF-1A family.
SIMILARITY: Contains 1 S1-like domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.86 RPKM in Heart - Left Ventricle
Total median expression: 238.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.3096-0.180 Picture PostScript Text
3' UTR -162.10808-0.201 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012340 - NA-bd_OB-fold
IPR016027 - NA-bd_OB-fold-like
IPR006196 - RNA-binding_domain_S1_IF1
IPR001253 - TIF_eIF-1A
IPR018104 - TIF_eIF-1A_CS

Pfam Domains:
PF01176 - Translation initiation factor 1A / IF-1

ModBase Predicted Comparative 3D Structure on O14602
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGD  WormBase 
Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding

Biological Process:
GO:0006412 translation
GO:0006413 translational initiation


-  Descriptions from all associated GenBank mRNAs
  AF000987 - Homo sapiens eIF-1A, Y isoform (EIF1AY) mRNA, complete cds.
DQ786267 - Homo sapiens clone HLS_IMAGE_305122 mRNA sequence.
BC005248 - Homo sapiens eukaryotic translation initiation factor 1A, Y-linked, mRNA (cDNA clone MGC:12282 IMAGE:3933718), complete cds.
DQ890576 - Synthetic construct clone IMAGE:100003206; FLH164080.01X; RZPDo839C06162D eukaryotic translation initiation factor 1A, Y-linked (EIF1AY) gene, encodes complete protein.
DQ893736 - Synthetic construct Homo sapiens clone IMAGE:100008196; FLH164076.01L; RZPDo839C06161D eukaryotic translation initiation factor 1A, Y-linked (EIF1AY) gene, encodes complete protein.
KJ892683 - Synthetic construct Homo sapiens clone ccsbBroadEn_02077 EIF1AY gene, encodes complete protein.
BT007201 - Homo sapiens eukaryotic translation initiation factor 1A, Y chromosome mRNA, complete cds.
JD070794 - Sequence 51818 from Patent EP1572962.
JD320729 - Sequence 301753 from Patent EP1572962.
AK127664 - Homo sapiens cDNA FLJ45762 fis, clone MESTC2000170.
JD419160 - Sequence 400184 from Patent EP1572962.
JD093517 - Sequence 74541 from Patent EP1572962.
JD327491 - Sequence 308515 from Patent EP1572962.
JD244299 - Sequence 225323 from Patent EP1572962.
JD564120 - Sequence 545144 from Patent EP1572962.
JD501651 - Sequence 482675 from Patent EP1572962.
JD044012 - Sequence 25036 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: IF1AY_HUMAN, NM_004681, O14602, Q9BS77, uc004fuk.1, uc004fuk.2, uc004fuk.3, uc004fuk.4, uc004fuk.5, uc004fuk.6
UCSC ID: uc004fuk.6
RefSeq Accession: NM_004681
Protein: O14602 (aka IF1AY_HUMAN or IF1Y_HUMAN)
CCDS: CCDS14795.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.