Human Gene EIF1AY (ENST00000361365.7) Description and Page Index
Description: Homo sapiens eukaryotic translation initiation factor 1A Y-linked (EIF1AY), transcript variant 1, mRNA. (from RefSeq NM_004681) RefSeq Summary (NM_004681): This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. Gencode Transcript: ENST00000361365.7 Gencode Gene: ENSG00000198692.10 Transcript (Including UTRs) Position: hg38 chrY:20,575,776-20,593,154 Size: 17,379 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chrY:20,575,872-20,592,346 Size: 16,475 Coding Exon Count: 7
ID:IF1AY_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 1A, Y-chromosomal; Short=eIF-1A Y isoform; AltName: Full=Eukaryotic translation initiation factor 4C; Short=eIF-4C; FUNCTION: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity). INTERACTION: O60841:EIF5B; NbExp=2; IntAct=EBI-286439, EBI-928530; TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the eIF-1A family. SIMILARITY: Contains 1 S1-like domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14602
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.