Human Gene REV3L (ENST00000358835.7) Description and Page Index
Description: Homo sapiens REV3 like, DNA directed polymerase zeta catalytic subunit (REV3L), transcript variant 1, mRNA. (from RefSeq NM_002912) RefSeq Summary (NM_002912): The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017]. Gencode Transcript: ENST00000358835.7 Gencode Gene: ENSG00000009413.15 Transcript (Including UTRs) Position: hg38 chr6:111,299,052-111,483,715 Size: 184,664 Total Exon Count: 33 Strand: - Coding Region Position: hg38 chr6:111,300,016-111,482,888 Size: 182,873 Coding Exon Count: 32
ID:DPOLZ_HUMAN DESCRIPTION: RecName: Full=DNA polymerase zeta catalytic subunit; EC=184.108.40.206; AltName: Full=Protein reversionless 3-like; Short=REV3-like; Short=hREV3; FUNCTION: Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis. CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). COFACTOR: Binds 1 4Fe-4S cluster (By similarity). SUBUNIT: Interacts with MAD2L2. SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Ubiquitously expressed. DOMAIN: Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis. DOMAIN: The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes (By similarity). SIMILARITY: Belongs to the DNA polymerase type-B family. SIMILARITY: Contains 1 CysA-type zinc finger. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/rev3l/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60673
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.