Human Gene CHD3 (ENST00000358181.8) Description and Page Index
Description: Homo sapiens chromodomain helicase DNA binding protein 3 (CHD3), transcript variant 2, mRNA. (from RefSeq NM_005852) RefSeq Summary (NM_005852): This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000358181.8 Gencode Gene: ENSG00000170004.17 Transcript (Including UTRs) Position: hg38 chr17:7,888,791-7,912,760 Size: 23,970 Total Exon Count: 39 Strand: + Coding Region Position: hg38 chr17:7,889,001-7,911,585 Size: 22,585 Coding Exon Count: 39
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08074 - CHDCT2 (NUC038) domain PF08073 - CHDNT (NUC034) domain PF00385 - Chromo (CHRromatin Organisation MOdifier) domain PF06461 - Domain of Unknown Function (DUF1086) PF06465 - Domain of Unknown Function (DUF1087) PF00271 - Helicase conserved C-terminal domain PF00628 - PHD-finger PF00176 - SNF2 family N-terminal domain
ModBase Predicted Comparative 3D Structure on Q12873
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.