Human Gene RTF2 (ENST00000357348.9) Description and Page Index
  Description: Homo sapiens replication termination factor 2 (RTF2), transcript variant 2, mRNA. (from RefSeq NM_016407)
Gencode Transcript: ENST00000357348.9
Gencode Gene: ENSG00000022277.12
Transcript (Including UTRs)
   Position: hg38 chr20:56,468,591-56,519,449 Size: 50,859 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr20:56,468,698-56,518,265 Size: 49,568 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:56,468,591-56,519,449)mRNA (may differ from genome)Protein (306 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGeneCardsHPRDMGIneXtProt
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CT043_HUMAN
DESCRIPTION: RecName: Full=UPF0549 protein C20orf43;
SIMILARITY: Belongs to the UPF0549 family.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 45.94 RPKM in Whole Blood
Total median expression: 1327.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.60107-0.426 Picture PostScript Text
3' UTR -385.201184-0.325 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006735 - DUF602

ModBase Predicted Comparative 3D Structure on Q9BY42
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process
GO:0071171 site-specific DNA replication termination at RTS1 barrier
GO:1902979 mitotic DNA replication termination

Cellular Component:
GO:0005575 cellular_component
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF383779 - JP 2014500723-A/191282: Polycomb-Associated Non-Coding RNAs.
MA619356 - JP 2018138019-A/191282: Polycomb-Associated Non-Coding RNAs.
AF161513 - Homo sapiens HSPC164 mRNA, complete cds.
AK314563 - Homo sapiens cDNA, FLJ95387.
AF117231 - Homo sapiens protein x 0001 mRNA, complete cds.
AK302029 - Homo sapiens cDNA FLJ52798 complete cds.
AF212244 - Homo sapiens CDA05 mRNA, complete cds.
AK000481 - Homo sapiens cDNA FLJ20474 fis, clone KAT07183.
AK293662 - Homo sapiens cDNA FLJ52477 complete cds.
AK026118 - Homo sapiens cDNA: FLJ22465 fis, clone HRC10233, highly similar to AF161518 Homo sapiens HSPC169 mRNA.
BC003359 - Homo sapiens chromosome 20 open reading frame 43, mRNA (cDNA clone MGC:5267 IMAGE:2900332), complete cds.
AF161518 - Homo sapiens HSPC169 mRNA, complete cds.
AK225135 - Homo sapiens mRNA for Protein C20orf43 variant, clone: CBL05465.
BC001536 - Homo sapiens cDNA clone IMAGE:3507294, containing frame-shift errors.
BC005017 - Homo sapiens chromosome 20 open reading frame 43, mRNA (cDNA clone IMAGE:3637705), **** WARNING: chimeric clone ****.
KJ898908 - Synthetic construct Homo sapiens clone ccsbBroadEn_08302 C20orf43 gene, encodes complete protein.
AK000586 - Homo sapiens cDNA FLJ20579 fis, clone REC00570.
JD372345 - Sequence 353369 from Patent EP1572962.
BC002769 - Homo sapiens chromosome 20 open reading frame 43, mRNA (cDNA clone IMAGE:3615348), complete cds.
KJ902599 - Synthetic construct Homo sapiens clone ccsbBroadEn_11993 C20orf43 gene, encodes complete protein.
LF205264 - JP 2014500723-A/12767: Polycomb-Associated Non-Coding RNAs.
MA440841 - JP 2018138019-A/12767: Polycomb-Associated Non-Coding RNAs.
LF318785 - JP 2014500723-A/126288: Polycomb-Associated Non-Coding RNAs.
MA554362 - JP 2018138019-A/126288: Polycomb-Associated Non-Coding RNAs.
LF350773 - JP 2014500723-A/158276: Polycomb-Associated Non-Coding RNAs.
MA586350 - JP 2018138019-A/158276: Polycomb-Associated Non-Coding RNAs.
LF350775 - JP 2014500723-A/158278: Polycomb-Associated Non-Coding RNAs.
MA586352 - JP 2018138019-A/158278: Polycomb-Associated Non-Coding RNAs.
AY320413 - Homo sapiens nasopharyngeal carcinoma-associated antigen SHUJUN-3 mRNA, complete cds.
LF206041 - JP 2014500723-A/13544: Polycomb-Associated Non-Coding RNAs.
MA441618 - JP 2018138019-A/13544: Polycomb-Associated Non-Coding RNAs.
LF350776 - JP 2014500723-A/158279: Polycomb-Associated Non-Coding RNAs.
MA586353 - JP 2018138019-A/158279: Polycomb-Associated Non-Coding RNAs.
JD059963 - Sequence 40987 from Patent EP1572962.
JD141189 - Sequence 122213 from Patent EP1572962.
JD488745 - Sequence 469769 from Patent EP1572962.
JD470240 - Sequence 451264 from Patent EP1572962.
JD111882 - Sequence 92906 from Patent EP1572962.
JD431997 - Sequence 413021 from Patent EP1572962.
JD134797 - Sequence 115821 from Patent EP1572962.
JD079021 - Sequence 60045 from Patent EP1572962.
JD091247 - Sequence 72271 from Patent EP1572962.
JD419588 - Sequence 400612 from Patent EP1572962.
JD359903 - Sequence 340927 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AD-007, C20orf43, CDA05, CT043_HUMAN, E1P5Z9, HSPC164, HSPC169, NM_016407, Q9BY42, Q9BYL7, Q9HCV9, Q9NX29, Q9NZZ8, Q9P002, Q9UHW3, uc002xxt.1, uc002xxt.2, uc002xxt.3, uc002xxt.4
UCSC ID: uc002xxt.4
RefSeq Accession: NM_016407
Protein: Q9BY42 (aka CT043_HUMAN or CT43_HUMAN)
CCDS: CCDS13453.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.