Human Gene KATNAL2 (ENST00000356157.12) Description and Page Index
  Description: Homo sapiens katanin catalytic subunit A1 like 2 (KATNAL2), transcript variant 13, non-coding RNA. (from RefSeq NR_148563)
Gencode Transcript: ENST00000356157.12
Gencode Gene: ENSG00000167216.17
Transcript (Including UTRs)
   Position: hg38 chr18:46,946,835-47,102,243 Size: 155,409 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg38 chr18:46,946,873-47,101,005 Size: 154,133 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr18:46,946,835-47,102,243)mRNA (may differ from genome)Protein (538 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Katanin p60 ATPase-containing subunit A-like 2; Short=Katanin p60 subunit A-like 2; EC=; AltName: Full=p60 katanin-like 2;
FUNCTION: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays (By similarity).
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity).
SIMILARITY: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
SIMILARITY: Contains 1 LisH domain.
SEQUENCE CAUTION: Sequence=BI560635; Type=Frameshift; Positions=183, 188, 200, 203;

-  MalaCards Disease Associations
  MalaCards Gene Search: KATNAL2
Diseases sorted by gene-association score: tinea capitis (17), dermatophytosis (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.40 RPKM in Testis
Total median expression: 80.36 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.6038-0.121 Picture PostScript Text
3' UTR -288.901238-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003593 - AAA+_ATPase
IPR003959 - ATPase_AAA_core
IPR006594 - LisH_dimerisation
IPR013720 - LisH_dimerisation_subgr

Pfam Domains:
PF00004 - ATPase family associated with various cellular activities (AAA)
PF08513 - LisH

ModBase Predicted Comparative 3D Structure on Q8IYT4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008568 microtubule-severing ATPase activity
GO:0016787 hydrolase activity
GO:0016887 ATPase activity

Biological Process:
GO:0051013 microtubule severing

Cellular Component:
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005874 microtubule

-  Descriptions from all associated GenBank mRNAs
  AK309134 - Homo sapiens cDNA, FLJ99175.
BC034999 - Homo sapiens katanin p60 subunit A-like 2, mRNA (cDNA clone MGC:33211 IMAGE:4829800), complete cds.
CU690016 - Synthetic construct Homo sapiens gateway clone IMAGE:100019530 5' read KATNAL2 mRNA.
HQ447324 - Synthetic construct Homo sapiens clone IMAGE:100070640; CCSB001887_02 katanin p60 subunit A-like 2 (KATNAL2) gene, encodes complete protein.
KJ899704 - Synthetic construct Homo sapiens clone ccsbBroadEn_09098 KATNAL2 gene, encodes complete protein.
AL512748 - Homo sapiens mRNA; cDNA DKFZp667C165 (from clone DKFZp667C165).

-  Other Names for This Gene
  Alternate Gene Symbols: KATL2_HUMAN, NR_148563, Q8IYT4, uc060ows.1, uc060ows.2
UCSC ID: uc060ows.2
RefSeq Accession: NM_001367621
Protein: Q8IYT4 (aka KATL2_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.