Human Gene AK5 (ENST00000354567.7) Description and Page Index
Description: Homo sapiens adenylate kinase 5 (AK5), transcript variant 1, mRNA. (from RefSeq NM_174858) RefSeq Summary (NM_174858): This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000354567.7 Gencode Gene: ENSG00000154027.19 Transcript (Including UTRs) Position: hg38 chr1:77,282,019-77,559,966 Size: 277,948 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr1:77,282,314-77,558,670 Size: 276,357 Coding Exon Count: 14
ID:KAD5_HUMAN DESCRIPTION: RecName: Full=Adenylate kinase isoenzyme 5; Short=AK 5; EC=220.127.116.11; AltName: Full=ATP-AMP transphosphorylase 5; FUNCTION: Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. CATALYTIC ACTIVITY: ATP + AMP = 2 ADP. SUBUNIT: Monomer (By similarity). SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Brain specific. SIMILARITY: Belongs to the adenylate kinase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6K8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.