Human Gene NRDC (ENST00000352171.11) Description and Page Index
  Description: Homo sapiens nardilysin convertase (NRDC), transcript variant 2, mRNA. (from RefSeq NM_001101662)
RefSeq Summary (NM_001101662): This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
Gencode Transcript: ENST00000352171.11
Gencode Gene: ENSG00000078618.21
Transcript (Including UTRs)
   Position: hg38 chr1:51,789,191-51,878,805 Size: 89,615 Total Exon Count: 31 Strand: -
Coding Region
   Position: hg38 chr1:51,789,236-51,878,615 Size: 89,380 Coding Exon Count: 31 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:51,789,191-51,878,805)mRNA (may differ from genome)Protein (1151 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGeneCardsLynxMGImyGene2
neXtProtOMIMPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Nardilysin; EC=; AltName: Full=N-arginine dibasic convertase; Short=NRD convertase; Short=NRD-C; Flags: Precursor;
FUNCTION: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
CATALYTIC ACTIVITY: Hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, and less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
TISSUE SPECIFICITY: Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.
SIMILARITY: Belongs to the peptidase M16 family.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 61.62 RPKM in Testis
Total median expression: 1184.95 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -85.20190-0.448 Picture PostScript Text
3' UTR -7.5045-0.167 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011249 - Metalloenz_metal-bd
IPR011237 - Pept_M16_core
IPR011765 - Pept_M16_N
IPR001431 - Pept_M16_Zn_BS
IPR007863 - Peptidase_M16_C

Pfam Domains:
PF00675 - Insulinase (Peptidase family M16)
PF05193 - Peptidase M16 inactive domain

ModBase Predicted Comparative 3D Structure on O43847
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0048408 epidermal growth factor binding

Biological Process:
GO:0006508 proteolysis
GO:0007528 neuromuscular junction development
GO:0008283 cell proliferation
GO:0016477 cell migration
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0052548 regulation of endopeptidase activity

Cellular Component:
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0009986 cell surface

-  Descriptions from all associated GenBank mRNAs
  AL832897 - Homo sapiens mRNA; cDNA DKFZp667L104 (from clone DKFZp667L104).
AY360265 - Homo sapiens nardilysin isoform (NRD1) mRNA, complete cds.
U64898 - Homo sapiens NRD convertase mRNA, complete cds.
BC008775 - Homo sapiens nardilysin (N-arginine dibasic convertase), mRNA (cDNA clone MGC:2024 IMAGE:3138712), complete cds.
X93207 - H.sapiens mRNA for NRD2 convertase.
X93209 - H.sapiens mRNA for NRD1 convertase.
AK055516 - Homo sapiens cDNA FLJ30954 fis, clone HCASM2000138, highly similar to NARDILYSIN PRECURSOR (EC
AK299271 - Homo sapiens cDNA FLJ60831 complete cds, highly similar to Nardilysin precursor (EC
AK312318 - Homo sapiens cDNA, FLJ92626.
AY049784 - Homo sapiens nardilysin (NRD1) mRNA, complete cds.
AK302616 - Homo sapiens cDNA FLJ59785 complete cds, highly similar to Nardilysin precursor (EC
HM370401 - Homo sapiens nardilysin 1-like (NRD1) mRNA, partial sequence, alternatively spliced.
JD246970 - Sequence 227994 from Patent EP1572962.
AK311631 - Homo sapiens cDNA, FLJ18673.
JD518310 - Sequence 499334 from Patent EP1572962.
JD523553 - Sequence 504577 from Patent EP1572962.
JD090102 - Sequence 71126 from Patent EP1572962.
JD462287 - Sequence 443311 from Patent EP1572962.
JD479854 - Sequence 460878 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NI41, NM_001101662, NRD1, NRDC_HUMAN, O15241, O15242, O43847, Q5VUL0, Q96HB2, Q9NU57, uc001ctd.1, uc001ctd.2, uc001ctd.3, uc001ctd.4, uc001ctd.5
UCSC ID: uc001ctd.5
RefSeq Accession: NM_001101662
Protein: O43847 (aka NRDC_HUMAN)
CCDS: CCDS41335.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.