Human Gene NRDC (ENST00000352171.11) Description and Page Index
Description: Homo sapiens nardilysin convertase (NRDC), transcript variant 2, mRNA. (from RefSeq NM_001101662) RefSeq Summary (NM_001101662): This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]. Gencode Transcript: ENST00000352171.11 Gencode Gene: ENSG00000078618.21 Transcript (Including UTRs) Position: hg38 chr1:51,789,191-51,878,805 Size: 89,615 Total Exon Count: 31 Strand: - Coding Region Position: hg38 chr1:51,789,236-51,878,615 Size: 89,380 Coding Exon Count: 31
ID:NRDC_HUMAN DESCRIPTION: RecName: Full=Nardilysin; EC=18.104.22.168; AltName: Full=N-arginine dibasic convertase; Short=NRD convertase; Short=NRD-C; Flags: Precursor; FUNCTION: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. CATALYTIC ACTIVITY: Hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, and less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys. COFACTOR: Binds 1 zinc ion per subunit (By similarity). TISSUE SPECIFICITY: Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues. SIMILARITY: Belongs to the peptidase M16 family.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Highest median expression: 61.62 RPKM in Testis
Total median expression: 1184.95 RPKM
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43847
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.