Human Gene NRDC (ENST00000352171.11) Description and Page Index
  Description: Homo sapiens nardilysin convertase (NRDC), transcript variant 2, mRNA. (from RefSeq NM_001101662)
RefSeq Summary (NM_001101662): This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
Gencode Transcript: ENST00000352171.11
Gencode Gene: ENSG00000078618.21
Transcript (Including UTRs)
   Position: hg38 chr1:51,789,191-51,878,805 Size: 89,615 Total Exon Count: 31 Strand: -
Coding Region
   Position: hg38 chr1:51,789,236-51,878,615 Size: 89,380 Coding Exon Count: 31 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:51,789,191-51,878,805)mRNA (may differ from genome)Protein (1151 aa)
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Entrez GeneExonPrimerGeneCardsLynxMGImyGene2
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-  Comments and Description Text from UniProtKB
  ID: NRDC_HUMAN
DESCRIPTION: RecName: Full=Nardilysin; EC=3.4.24.61; AltName: Full=N-arginine dibasic convertase; Short=NRD convertase; Short=NRD-C; Flags: Precursor;
FUNCTION: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
CATALYTIC ACTIVITY: Hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, and less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
TISSUE SPECIFICITY: Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.
SIMILARITY: Belongs to the peptidase M16 family.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 61.62 RPKM in Testis
Total median expression: 1184.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -85.20190-0.448 Picture PostScript Text
3' UTR -7.5045-0.167 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011249 - Metalloenz_metal-bd
IPR011237 - Pept_M16_core
IPR011765 - Pept_M16_N
IPR001431 - Pept_M16_Zn_BS
IPR007863 - Peptidase_M16_C

Pfam Domains:
PF00675 - Insulinase (Peptidase family M16)
PF05193 - Peptidase M16 inactive domain

ModBase Predicted Comparative 3D Structure on O43847
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0048408 epidermal growth factor binding

Biological Process:
GO:0006508 proteolysis
GO:0007528 neuromuscular junction development
GO:0008283 cell proliferation
GO:0016477 cell migration
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0052548 regulation of endopeptidase activity

Cellular Component:
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0009986 cell surface


-  Descriptions from all associated GenBank mRNAs
  AL832897 - Homo sapiens mRNA; cDNA DKFZp667L104 (from clone DKFZp667L104).
AY360265 - Homo sapiens nardilysin isoform (NRD1) mRNA, complete cds.
U64898 - Homo sapiens NRD convertase mRNA, complete cds.
BC008775 - Homo sapiens nardilysin (N-arginine dibasic convertase), mRNA (cDNA clone MGC:2024 IMAGE:3138712), complete cds.
X93207 - H.sapiens mRNA for NRD2 convertase.
X93209 - H.sapiens mRNA for NRD1 convertase.
AK055516 - Homo sapiens cDNA FLJ30954 fis, clone HCASM2000138, highly similar to NARDILYSIN PRECURSOR (EC 3.4.24.61).
AK299271 - Homo sapiens cDNA FLJ60831 complete cds, highly similar to Nardilysin precursor (EC 3.4.24.61).
AK312318 - Homo sapiens cDNA, FLJ92626.
AY049784 - Homo sapiens nardilysin (NRD1) mRNA, complete cds.
AK302616 - Homo sapiens cDNA FLJ59785 complete cds, highly similar to Nardilysin precursor (EC 3.4.24.61).
HM370401 - Homo sapiens nardilysin 1-like (NRD1) mRNA, partial sequence, alternatively spliced.
JD246970 - Sequence 227994 from Patent EP1572962.
AK311631 - Homo sapiens cDNA, FLJ18673.
JD518310 - Sequence 499334 from Patent EP1572962.
JD523553 - Sequence 504577 from Patent EP1572962.
JD090102 - Sequence 71126 from Patent EP1572962.
JD462287 - Sequence 443311 from Patent EP1572962.
JD479854 - Sequence 460878 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NI41, NM_001101662, NRD1, NRDC_HUMAN, O15241, O15242, O43847, Q5VUL0, Q96HB2, Q9NU57, uc001ctd.1, uc001ctd.2, uc001ctd.3, uc001ctd.4, uc001ctd.5
UCSC ID: uc001ctd.5
RefSeq Accession: NM_001101662
Protein: O43847 (aka NRDC_HUMAN)
CCDS: CCDS41335.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.