Human Gene MIA2 (ENST00000348007.7) Description and Page Index
Description: Homo sapiens MIA SH3 domain ER export factor 2 (MIA2), transcript variant 3, mRNA. (from RefSeq NM_203355) RefSeq Summary (NM_203355): This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016]. Gencode Transcript: ENST00000348007.7 Gencode Gene: ENSG00000150527.17 Transcript (Including UTRs) Position: hg38 chr14:39,267,414-39,350,694 Size: 83,281 Total Exon Count: 23 Strand: + Coding Region Position: hg38 chr14:39,267,460-39,350,264 Size: 82,805 Coding Exon Count: 23
ID:MIA2_HUMAN DESCRIPTION: RecName: Full=Melanoma inhibitory activity protein 2; Flags: Precursor; FUNCTION: May play a role in the pathophysiology of liver disease and may serve as a marker of liver damage. SUBCELLULAR LOCATION: Secreted (Potential). TISSUE SPECIFICITY: Highly expressed in liver and weakly in testis. Expression was higher in patients with severe fibrosis or inflammation and chronic hepatitis. SIMILARITY: Belongs to the MIA/OTOR family. SIMILARITY: Contains 1 SH3 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96PC5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.