Human Gene TM2D3 (ENST00000347970.7) Description and Page Index
  Description: Homo sapiens TM2 domain containing 3 (TM2D3), transcript variant 2, mRNA. (from RefSeq NM_025141)
RefSeq Summary (NM_025141): The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. Several alternatively spliced transcript variants of this gene are described but the full length nature of some variants has not been determined. Multiple polyadenylation sites have been found in this gene. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000347970.7
Gencode Gene: ENSG00000184277.13
Transcript (Including UTRs)
   Position: hg38 chr15:101,641,846-101,652,391 Size: 10,546 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr15:101,642,479-101,652,361 Size: 9,883 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:101,641,846-101,652,391)mRNA (may differ from genome)Protein (221 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: TM2D3_HUMAN
DESCRIPTION: RecName: Full=TM2 domain-containing protein 3; AltName: Full=Beta-amyloid-binding protein-like protein 2; Short=BBP-like protein 2; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: Belongs to the TM2 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.94 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 491.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.2030-0.340 Picture PostScript Text
3' UTR -148.40633-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007829 - TM2

Pfam Domains:
PF05154 - TM2 domain

ModBase Predicted Comparative 3D Structure on Q9BRN9
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD Ensembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK297048 - Homo sapiens cDNA FLJ58020 complete cds, highly similar to Homo sapiens TM2 domain containing 3 (TM2D3), transcript variant 2, mRNA.
AL512689 - Homo sapiens mRNA; cDNA DKFZp667C1011 (from clone DKFZp667C1011).
BC006150 - Homo sapiens TM2 domain containing 3, mRNA (cDNA clone MGC:13164 IMAGE:3051281), complete cds.
AK094955 - Homo sapiens cDNA FLJ37636 fis, clone BRCOC2018775, highly similar to Homo sapiens TM2 domain containing 3 (TM2D3), transcript variant 1, mRNA.
BC008873 - Homo sapiens TM2 domain containing 3, mRNA (cDNA clone MGC:14889 IMAGE:4137334), complete cds.
AK026257 - Homo sapiens cDNA: FLJ22604 fis, clone HSI04630.
AF353992 - Homo sapiens BBP-like protein 2 (BLP2) mRNA, complete cds.
JD314215 - Sequence 295239 from Patent EP1572962.
JD491535 - Sequence 472559 from Patent EP1572962.
JD453394 - Sequence 434418 from Patent EP1572962.
AK315584 - Homo sapiens cDNA, FLJ96662, Homo sapiens BBP-like protein 2 (BLP2), transcript variant 1, mRNA.
KJ899620 - Synthetic construct Homo sapiens clone ccsbBroadEn_09014 TM2D3 gene, encodes complete protein.
KJ899621 - Synthetic construct Homo sapiens clone ccsbBroadEn_09015 TM2D3 gene, encodes complete protein.
AK296553 - Homo sapiens cDNA FLJ57737 complete cds, highly similar to Homo sapiens TM2 domain containing 3 (TM2D3), transcript variant 1, mRNA.
JD024142 - Sequence 5166 from Patent EP1572962.
JD032012 - Sequence 13036 from Patent EP1572962.
JD020007 - Sequence 1031 from Patent EP1572962.
JD026870 - Sequence 7894 from Patent EP1572962.
JD034297 - Sequence 15321 from Patent EP1572962.
JD029535 - Sequence 10559 from Patent EP1572962.
JD032922 - Sequence 13946 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RDK9, BLP2, NM_025141, Q9BRN9, Q9H046, Q9H651, TM2D3_HUMAN, uc002bxj.1, uc002bxj.2, uc002bxj.3
UCSC ID: uc002bxj.3
RefSeq Accession: NM_025141
Protein: Q9BRN9 (aka TM2D3_HUMAN)
CCDS: CCDS10392.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.