Human Gene TMPRSS6 (ENST00000346753.8) Description and Page Index
  Description: Homo sapiens transmembrane serine protease 6 (TMPRSS6), transcript variant 2, mRNA. (from RefSeq NM_153609)
RefSeq Summary (NM_153609): The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY055384.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000346753.8
Gencode Gene: ENSG00000187045.18
Transcript (Including UTRs)
   Position: hg38 chr22:37,065,436-37,103,653 Size: 38,218 Total Exon Count: 18 Strand: -
Coding Region
   Position: hg38 chr22:37,066,080-37,103,539 Size: 37,460 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:37,065,436-37,103,653)mRNA (may differ from genome)Protein (811 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: TMPS6_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protease serine 6; EC=3.4.21.-; AltName: Full=Matriptase-2;
FUNCTION: Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Plays a role in the regulation of iron homeostasis, a process involving HAMP. Required to sense iron deficiency and suppress activation of the HAMP promoter.
SUBUNIT: Interacts with HFE2.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein.
TISSUE SPECIFICITY: Liver specific.
DOMAIN: Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s) (By similarity).
PTM: The single-chain zymogen undergoes proteolytic processing. This results in TMPRSS6 shedding from the cell surface and conversion into an activated two-chains form. The process involves a trans-activation mechanism that requires TMPRSS6 oligomerization.
DISEASE: Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA) [MIM:206200]; also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron. Note=Mutations leading to abrogation of TMPRSS6 activity are associated with IRIDA due to elevated levels of hepcidin, a negative regulator of plasma iron pool (PubMed:20232450).
SIMILARITY: Belongs to the peptidase S1 family.
SIMILARITY: Contains 2 CUB domains.
SIMILARITY: Contains 3 LDL-receptor class A domains.
SIMILARITY: Contains 1 peptidase S1 domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: TMPRSS6
Diseases sorted by gene-association score: iron-refractory iron deficiency anemia* (1693), microcytic anemia* (427), iron deficiency anemia (59), deficiency anemia (47), hypochromic microcytic anemia (19), nutritional deficiency disease (6), hemochromatosis (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.89 RPKM in Liver
Total median expression: 60.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.50114-0.285 Picture PostScript Text
3' UTR -291.40644-0.452 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000859 - CUB
IPR002172 - LDrepeatLR_classA_rpt
IPR009003 - Pept_cys/ser_Trypsin-like
IPR017118 - Pept_S1A_matriptase-2
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A
IPR000082 - SEA

Pfam Domains:
PF00057 - Low-density lipoprotein receptor domain class A
PF01390 - SEA domain
PF00089 - Trypsin

ModBase Predicted Comparative 3D Structure on Q8IU80
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004222 metalloendopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0006508 proteolysis
GO:0006879 cellular iron ion homeostasis
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030514 negative regulation of BMP signaling pathway
GO:0030574 collagen catabolic process
GO:0033619 membrane protein proteolysis
GO:0035556 intracellular signal transduction
GO:0042730 fibrinolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0055072 iron ion homeostasis
GO:0097264 self proteolysis

Cellular Component:
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY055384 - Homo sapiens type II transmembrane serine protease 6 (TMPRSS6) mRNA, complete cds.
AY358398 - Homo sapiens clone DNA49152 PVAE354 (UNQ354) mRNA, complete cds.
CR456446 - Homo sapiens dJ1170K4.2 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ1170K4.2).
AJ319876 - Homo sapiens mRNA for matriptase-2.
CU013044 - Homo sapiens TMPRSS6, mRNA (cDNA clone IMAGE:100000302), complete cds, with stop codon, in Gateway system.
AB587483 - Synthetic construct DNA, clone: pF1KB8647, Homo sapiens TMPRSS6 gene for transmembrane protease, serine 6, without stop codon, in Flexi system.
CU013332 - Homo sapiens TMPRSS6, mRNA (cDNA clone IMAGE:100000206), complete cds, without stop codon, in Gateway system.
BC039082 - Homo sapiens transmembrane protease, serine 6, mRNA (cDNA clone MGC:35027 IMAGE:5164881), complete cds.
KJ903946 - Synthetic construct Homo sapiens clone ccsbBroadEn_13340 TMPRSS6 gene, encodes complete protein.
CU691658 - Synthetic construct Homo sapiens gateway clone IMAGE:100019507 5' read TMPRSS6 mRNA.
JD414616 - Sequence 395640 from Patent EP1572962.
JD192261 - Sequence 173285 from Patent EP1572962.
JD537013 - Sequence 518037 from Patent EP1572962.
JD381716 - Sequence 362740 from Patent EP1572962.
JD157884 - Sequence 138908 from Patent EP1572962.
JD393537 - Sequence 374561 from Patent EP1572962.
LF656473 - JP 2016520593-A/275: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175406 - KR 1020160009687-A/279: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656340 - JP 2016520593-A/142: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175273 - KR 1020160009687-A/146: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656472 - JP 2016520593-A/274: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175405 - KR 1020160009687-A/278: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656471 - JP 2016520593-A/273: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175404 - KR 1020160009687-A/277: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656336 - JP 2016520593-A/138: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LF656470 - JP 2016520593-A/272: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175269 - KR 1020160009687-A/142: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LG175403 - KR 1020160009687-A/276: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656316 - JP 2016520593-A/118: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175249 - KR 1020160009687-A/122: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656321 - JP 2016520593-A/123: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175254 - KR 1020160009687-A/127: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656469 - JP 2016520593-A/271: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175402 - KR 1020160009687-A/275: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656468 - JP 2016520593-A/270: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175401 - KR 1020160009687-A/274: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656341 - JP 2016520593-A/143: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175274 - KR 1020160009687-A/147: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656335 - JP 2016520593-A/137: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175268 - KR 1020160009687-A/141: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
JD565701 - Sequence 546725 from Patent EP1572962.
JD138772 - Sequence 119796 from Patent EP1572962.
JD485768 - Sequence 466792 from Patent EP1572962.
JD475024 - Sequence 456048 from Patent EP1572962.
LF656467 - JP 2016520593-A/269: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175400 - KR 1020160009687-A/273: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656331 - JP 2016520593-A/133: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LF656466 - JP 2016520593-A/268: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175264 - KR 1020160009687-A/137: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LG175399 - KR 1020160009687-A/272: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656311 - JP 2016520593-A/113: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175244 - KR 1020160009687-A/117: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
JD059948 - Sequence 40972 from Patent EP1572962.
LF656465 - JP 2016520593-A/267: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175398 - KR 1020160009687-A/271: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656464 - JP 2016520593-A/266: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175397 - KR 1020160009687-A/270: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656326 - JP 2016520593-A/128: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175259 - KR 1020160009687-A/132: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656345 - JP 2016520593-A/147: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175278 - KR 1020160009687-A/151: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656463 - JP 2016520593-A/265: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175396 - KR 1020160009687-A/269: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656462 - JP 2016520593-A/264: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175395 - KR 1020160009687-A/268: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656307 - JP 2016520593-A/109: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175240 - KR 1020160009687-A/113: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656329 - JP 2016520593-A/131: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175262 - KR 1020160009687-A/135: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656460 - JP 2016520593-A/262: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175393 - KR 1020160009687-A/266: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656324 - JP 2016520593-A/126: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175257 - KR 1020160009687-A/130: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656459 - JP 2016520593-A/261: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175392 - KR 1020160009687-A/265: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656457 - JP 2016520593-A/259: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175390 - KR 1020160009687-A/263: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656458 - JP 2016520593-A/260: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175391 - KR 1020160009687-A/264: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656455 - JP 2016520593-A/257: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175388 - KR 1020160009687-A/261: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656456 - JP 2016520593-A/258: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175389 - KR 1020160009687-A/262: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656352 - JP 2016520593-A/154: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175285 - KR 1020160009687-A/158: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656351 - JP 2016520593-A/153: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175284 - KR 1020160009687-A/157: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656454 - JP 2016520593-A/256: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175387 - KR 1020160009687-A/260: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656343 - JP 2016520593-A/145: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LF656453 - JP 2016520593-A/255: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175276 - KR 1020160009687-A/149: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LG175386 - KR 1020160009687-A/259: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656320 - JP 2016520593-A/122: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175253 - KR 1020160009687-A/126: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656452 - JP 2016520593-A/254: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175385 - KR 1020160009687-A/258: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656451 - JP 2016520593-A/253: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175384 - KR 1020160009687-A/257: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656348 - JP 2016520593-A/150: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175281 - KR 1020160009687-A/154: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656450 - JP 2016520593-A/252: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175383 - KR 1020160009687-A/256: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656350 - JP 2016520593-A/152: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175283 - KR 1020160009687-A/156: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656448 - JP 2016520593-A/250: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175381 - KR 1020160009687-A/254: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656314 - JP 2016520593-A/116: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175247 - KR 1020160009687-A/120: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656447 - JP 2016520593-A/249: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175380 - KR 1020160009687-A/253: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656309 - JP 2016520593-A/111: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LF656446 - JP 2016520593-A/248: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175242 - KR 1020160009687-A/115: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LG175379 - KR 1020160009687-A/252: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656338 - JP 2016520593-A/140: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LF656445 - JP 2016520593-A/247: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175271 - KR 1020160009687-A/144: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LG175378 - KR 1020160009687-A/251: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656444 - JP 2016520593-A/246: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175377 - KR 1020160009687-A/250: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656325 - JP 2016520593-A/127: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LF656443 - JP 2016520593-A/245: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175258 - KR 1020160009687-A/131: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LG175376 - KR 1020160009687-A/249: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656442 - JP 2016520593-A/244: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175375 - KR 1020160009687-A/248: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656441 - JP 2016520593-A/243: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175374 - KR 1020160009687-A/247: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656440 - JP 2016520593-A/242: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175373 - KR 1020160009687-A/246: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656439 - JP 2016520593-A/241: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175372 - KR 1020160009687-A/245: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656438 - JP 2016520593-A/240: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175371 - KR 1020160009687-A/244: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656334 - JP 2016520593-A/136: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175267 - KR 1020160009687-A/140: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656437 - JP 2016520593-A/239: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175370 - KR 1020160009687-A/243: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656436 - JP 2016520593-A/238: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175369 - KR 1020160009687-A/242: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656433 - JP 2016520593-A/235: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175366 - KR 1020160009687-A/239: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656330 - JP 2016520593-A/132: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175263 - KR 1020160009687-A/136: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656432 - JP 2016520593-A/234: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175365 - KR 1020160009687-A/238: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656313 - JP 2016520593-A/115: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175246 - KR 1020160009687-A/119: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656430 - JP 2016520593-A/232: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175363 - KR 1020160009687-A/236: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656431 - JP 2016520593-A/233: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175364 - KR 1020160009687-A/237: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656347 - JP 2016520593-A/149: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175280 - KR 1020160009687-A/153: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656427 - JP 2016520593-A/229: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175360 - KR 1020160009687-A/233: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656317 - JP 2016520593-A/119: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175250 - KR 1020160009687-A/123: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656426 - JP 2016520593-A/228: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175359 - KR 1020160009687-A/232: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656339 - JP 2016520593-A/141: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175272 - KR 1020160009687-A/145: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656425 - JP 2016520593-A/227: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175358 - KR 1020160009687-A/231: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656312 - JP 2016520593-A/114: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175245 - KR 1020160009687-A/118: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656424 - JP 2016520593-A/226: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175357 - KR 1020160009687-A/230: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656319 - JP 2016520593-A/121: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175252 - KR 1020160009687-A/125: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656423 - JP 2016520593-A/225: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175356 - KR 1020160009687-A/229: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656421 - JP 2016520593-A/223: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175354 - KR 1020160009687-A/227: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656342 - JP 2016520593-A/144: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175275 - KR 1020160009687-A/148: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656420 - JP 2016520593-A/222: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175353 - KR 1020160009687-A/226: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656318 - JP 2016520593-A/120: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175251 - KR 1020160009687-A/124: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656419 - JP 2016520593-A/221: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175352 - KR 1020160009687-A/225: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656332 - JP 2016520593-A/134: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LF656418 - JP 2016520593-A/220: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175265 - KR 1020160009687-A/138: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LG175351 - KR 1020160009687-A/224: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656327 - JP 2016520593-A/129: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175260 - KR 1020160009687-A/133: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656417 - JP 2016520593-A/219: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175350 - KR 1020160009687-A/223: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656337 - JP 2016520593-A/139: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175270 - KR 1020160009687-A/143: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656416 - JP 2016520593-A/218: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175349 - KR 1020160009687-A/222: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656333 - JP 2016520593-A/135: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175266 - KR 1020160009687-A/139: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656415 - JP 2016520593-A/217: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175348 - KR 1020160009687-A/221: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656414 - JP 2016520593-A/216: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175347 - KR 1020160009687-A/220: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656322 - JP 2016520593-A/124: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175255 - KR 1020160009687-A/128: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656310 - JP 2016520593-A/112: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175243 - KR 1020160009687-A/116: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656405 - JP 2016520593-A/207: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175338 - KR 1020160009687-A/211: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
LF656308 - JP 2016520593-A/110: TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF.
LG175241 - KR 1020160009687-A/114: TMPRSS6 COMPOSITIONS AND METHODS OF USE THEREOF.
JD526195 - Sequence 507219 from Patent EP1572962.
JD264775 - Sequence 245799 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8IU80 (Reactome details) participates in the following event(s):

R-HSA-1458433 Collagen type I degradation by MMP14
R-HSA-1474196 Collagen type II degradation by MMP14
R-HSA-1474210 Collagen type III degradation by MMP14
R-NUL-2473583 Collagen type I degradation by MMP14
R-NUL-2473590 Collagen type II degradation by MMP14
R-HSA-2514831 Fibrillin-1 degradation by MMP14
R-HSA-2533874 Laminin-511 degradation by MMP14
R-NUL-2533890 Laminin-511 degradation by MMP14
R-HSA-2533950 Fibronectin degradation by MMP14, TMPRSS6
R-HSA-3791155 Laminin-322 degradation by MMP14
R-HSA-3828025 DCN (decorin) degradation by MMP14
R-HSA-1442490 Collagen degradation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1474244 Extracellular matrix organization

-  Other Names for This Gene
  Alternate Gene Symbols: B0QYB4, B0QYB7, B0QYB8, NM_153609, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8, TMPS6_HUMAN, uc003aqs.1, uc003aqs.2, uc003aqs.3, uc003aqs.4, UNQ354/PRO618
UCSC ID: uc003aqs.4
RefSeq Accession: NM_153609
Protein: Q8IU80 (aka TMPS6_HUMAN or TMS6_HUMAN)
CCDS: CCDS13941.1, CCDS74856.1, CCDS74857.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.