Human Gene UGT1A10 (ENST00000344644.9) Description and Page Index
  Description: Homo sapiens UDP glucuronosyltransferase family 1 member A10 (UGT1A10), mRNA. (from RefSeq NM_019075)
RefSeq Summary (NM_019075): This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020971.1, BC069210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000344644.9
Gencode Gene: ENSG00000242515.5
Transcript (Including UTRs)
   Position: hg38 chr2:233,636,454-233,773,305 Size: 136,852 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr2:233,636,523-233,772,559 Size: 136,037 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:233,636,454-233,773,305)mRNA (may differ from genome)Protein (530 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: UD110_HUMAN
DESCRIPTION: RecName: Full=UDP-glucuronosyltransferase 1-10; Short=UDPGT 1-10; Short=UGT1*10; Short=UGT1-10; Short=UGT1.10; EC=2.4.1.17; AltName: Full=UDP-glucuronosyltransferase 1-J; Short=UGT-1J; Short=UGT1J; AltName: Full=UDP-glucuronosyltransferase 1A10; Flags: Precursor;
FUNCTION: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
CATALYTIC ACTIVITY: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
SUBCELLULAR LOCATION: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential).
TISSUE SPECIFICITY: Liver and colon.
SIMILARITY: Belongs to the UDP-glycosyltransferase family.

-  MalaCards Disease Associations
  MalaCards Gene Search: UGT1A10
Diseases sorted by gene-association score: pericholangitis (11)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.06 RPKM in Colon - Transverse
Total median expression: 28.63 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.0069-0.217 Picture PostScript Text
3' UTR -171.70746-0.230 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002213 - UDP_glucos_trans

Pfam Domains:
PF00201 - UDP-glucoronosyl and UDP-glucosyl transferase

ModBase Predicted Comparative 3D Structure on Q9HAW8
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005080 protein kinase C binding
GO:0015020 glucuronosyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016758 transferase activity, transferring hexosyl groups
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0001972 retinoic acid binding

Biological Process:
GO:0008152 metabolic process
GO:0045922 negative regulation of fatty acid metabolic process
GO:0051552 flavone metabolic process
GO:0052695 cellular glucuronidation
GO:0052696 flavonoid glucuronidation
GO:0052697 xenobiotic glucuronidation
GO:1904224 negative regulation of glucuronosyltransferase activity
GO:2001030 negative regulation of cellular glucuronidation
GO:0017144 drug metabolic process

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  KJ902675 - Synthetic construct Homo sapiens clone ccsbBroadEn_12069 UGT1A4 gene, encodes complete protein.
KJ894051 - Synthetic construct Homo sapiens clone ccsbBroadEn_03445 UGT1A1 gene, encodes complete protein.
KJ899004 - Synthetic construct Homo sapiens clone ccsbBroadEn_08398 UGT1A4 gene, encodes complete protein.
KJ894047 - Synthetic construct Homo sapiens clone ccsbBroadEn_03441 UGT1A9 gene, encodes complete protein.
KJ899000 - Synthetic construct Homo sapiens clone ccsbBroadEn_08394 UGT1A6 gene, encodes complete protein.
AF462268 - Homo sapiens UDP-glucuronosyltransferase UGT1A8*1 (UGT1A8) mRNA, UGT1A8*1 allele, complete cds.
AK313488 - Homo sapiens cDNA, FLJ94041, highly similar to Homo sapiens UDP glycosyltransferase 1 family, polypeptide A8 (UGT1A8), mRNA.
AF462267 - Homo sapiens UDP-glucuronosyltransferase UGT1A8*2 (UGT1A8) mRNA, UGT1A8*2 allele, complete cds.
BC156848 - Synthetic construct Homo sapiens clone IMAGE:100062577, MGC:190569 UDP glucuronosyltransferase 1 family, polypeptide A8 (UGT1A8) mRNA, encodes complete protein.
AF030310 - Homo sapiens UDP-glucuronosyltransferase 1A8 (UGT1A8) mRNA, complete cds.
AY435143 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A8 (UGT1A8) mRNA, complete cds.
DQ364251 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A8s (UGT1A8S) mRNA, partial cds.
BC020971 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A10, mRNA (cDNA clone MGC:9353 IMAGE:3850654), complete cds.
BC069210 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A10, mRNA (cDNA clone MGC:78613 IMAGE:4660540), complete cds.
BC053576 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A10, mRNA (cDNA clone MGC:61718 IMAGE:4452440), complete cds.
HQ257908 - Synthetic construct Homo sapiens clone IMAGE:100072217 Unknown protein gene, encodes complete protein.
KJ902667 - Synthetic construct Homo sapiens clone ccsbBroadEn_12061 UGT1A10 gene, encodes complete protein.
KR711079 - Synthetic construct Homo sapiens clone CCSBHm_00020087 UGT1A10 (UGT1A10) mRNA, encodes complete protein.
KR711080 - Synthetic construct Homo sapiens clone CCSBHm_00020088 UGT1A10 (UGT1A10) mRNA, encodes complete protein.
KR711081 - Synthetic construct Homo sapiens clone CCSBHm_00020093 UGT1A10 (UGT1A10) mRNA, encodes complete protein.
KR711082 - Synthetic construct Homo sapiens clone CCSBHm_00020115 UGT1A10 (UGT1A10) mRNA, encodes complete protein.
KJ904770 - Synthetic construct Homo sapiens clone ccsbBroadEn_14164 UGT1A10 gene, encodes complete protein.
U89508 - Human UDP-glucuronosyltransferase 1A10 mRNA, complete cds.
AY435137 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A10 (UGT1A10) mRNA, complete cds.
AK025403 - Homo sapiens cDNA: FLJ21750 fis, clone COLF5999, highly similar to AF056188 Homo sapiens UDP-glucuronosyltransferase 1A9 (UGT1A9) mRNA.
AK313510 - Homo sapiens cDNA, FLJ94068, Homo sapiens UDP glycosyltransferase 1 family, polypeptide A9(UGT1A9), mRNA.
BC058844 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A9, mRNA (cDNA clone MGC:61893 IMAGE:4593613), complete cds.
BC043491 - Homo sapiens cDNA clone IMAGE:5183433, containing frame-shift errors.
AF056188 - Homo sapiens UDP-glucuronosyltransferase 1A9 (UGT1A9) mRNA, complete cds.
AY435144 - Homo sapiens UDP glycosyltransferase 1 family polypeptide 9 (UGT1A9) mRNA, complete cds.
S55985 - Homo sapiens UDP-glucuronosyltransferase mRNA, complete cds.
DQ364246 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A9s (UGT1A9S) mRNA, partial cds.
AB527235 - Synthetic construct DNA, clone: pF1KE0362, Homo sapiens UGT1A7 gene for UDP glucuronosyltransferase 1 family, polypeptide A7, without stop codon, in Flexi system.
BC146418 - Synthetic construct Homo sapiens clone IMAGE:100015126, MGC:180213 UDP glucuronosyltransferase 1 family, polypeptide A7 (UGT1A7) mRNA, encodes complete protein.
BC153172 - Synthetic construct Homo sapiens clone IMAGE:100016516, MGC:184270 UDP glucuronosyltransferase 1 family, polypeptide A7 (UGT1A7) mRNA, encodes complete protein.
U89507 - Human UDP-glucuronosyltransferase 1A7 mRNA, complete cds.
AY435142 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A7 (UGT1A7) mRNA, complete cds.
DQ383513 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A7s (UGT1A7) mRNA, partial cds, alternatively spliced.
BC011409 - Homo sapiens cDNA clone IMAGE:3854370, containing frame-shift errors.
BC019861 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A6, mRNA (cDNA clone MGC:29860 IMAGE:4454322), complete cds.
J04093 - Homo sapiens phenol UDP-glucuronosyltransferase (UDPGT) mRNA, complete cds.
DQ364250 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A6s (UGT1A6S) mRNA, complete cds.
AY435141 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A6 (UGT1A6) mRNA, complete cds.
JD508072 - Sequence 489096 from Patent EP1572962.
JD068516 - Sequence 49540 from Patent EP1572962.
CU676796 - Synthetic construct Homo sapiens gateway clone IMAGE:100019795 5' read UGT1A10 mRNA.
BC141470 - Synthetic construct Homo sapiens clone IMAGE:100014695, MGC:175337 UDP glucuronosyltransferase 1 family, polypeptide A5 (UGT1A5) mRNA, encodes complete protein.
AY435140 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A5 (UGT1A5) mRNA, complete cds.
DQ383514 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A5s (UGT1A5) mRNA, partial cds, alternatively spliced.
AK313623 - Homo sapiens cDNA, FLJ94193, highly similar to Homo sapiens UDP glycosyltransferase 1 family, polypeptide A4(UGT1A4), mRNA.
M57951 - Human bilirubin UDP-glucuronosyltransferase isozyme 2 mRNA, complete cds.
BC139784 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A4, mRNA (cDNA clone MGC:156183 IMAGE:40117089), complete cds.
DQ364249 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A4s (UGT1A4S) mRNA, complete cds.
BC121036 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A4, mRNA (cDNA clone MGC:149704 IMAGE:40117585), complete cds.
AY435139 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A4 (UGT1A4) mRNA, complete cds.
BC131623 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A4, mRNA (cDNA clone IMAGE:40117575), partial cds.
BC166641 - Synthetic construct Homo sapiens clone IMAGE:100066367, MGC:195504 UDP glucuronosyltransferase 1 family, polypeptide A3 (UGT1A3) mRNA, encodes complete protein.
AY435138 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A3 (UGT1A3) mRNA, complete cds.
DQ364248 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A3s (UGT1A3S) mRNA, partial cds.
LF205292 - JP 2014500723-A/12795: Polycomb-Associated Non-Coding RNAs.
MA440869 - JP 2018138019-A/12795: Polycomb-Associated Non-Coding RNAs.
AK290834 - Homo sapiens cDNA FLJ75264 complete cds, highly similar to Human bilirubin UDP-glucuronosyltransferase isozyme 1 mRNA.
BC128414 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A1, mRNA (cDNA clone MGC:156187 IMAGE:40117598), complete cds.
BC128415 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A1, mRNA (cDNA clone MGC:156188 IMAGE:40117599), complete cds.
M57899 - Human bilirubin UDP-glucuronosyltransferase isozyme 1 mRNA, complete cds.
DQ364247 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A1s (UGT1A1S) mRNA, complete cds.
AY435136 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A1 (UGT1A1) mRNA, complete cds.
JQ686667 - Homo sapiens UDP-glucuronosyltransferase (UGT1A1) mRNA, complete cds.
JQ699637 - Homo sapiens isolate A64S UDP-glucuronosyltransferase 1-1 (BILIQTL1) mRNA, complete cds.
JQ699638 - Homo sapiens isolate D70H UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.
JQ699639 - Homo sapiens isolate G71E UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.
JQ699640 - Homo sapiens isolate K114K UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.
JQ699641 - Homo sapiens isolate S143N UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.
JQ699642 - Homo sapiens isolate D146Y UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.
JQ699643 - Homo sapiens isolate S191P UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.
JQ699644 - Homo sapiens isolate R257K UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.
JQ699645 - Homo sapiens isolate W335R UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.
JQ699646 - Homo sapiens isolate S343S UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.
JQ699647 - Homo sapiens isolate T349T UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.
JQ699649 - Homo sapiens isolate T482T UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.
JQ699650 - Homo sapiens isolate L489V UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.
LF318915 - JP 2014500723-A/126418: Polycomb-Associated Non-Coding RNAs.
MA554492 - JP 2018138019-A/126418: Polycomb-Associated Non-Coding RNAs.
LF318916 - JP 2014500723-A/126419: Polycomb-Associated Non-Coding RNAs.
MA554493 - JP 2018138019-A/126419: Polycomb-Associated Non-Coding RNAs.
LF318917 - JP 2014500723-A/126420: Polycomb-Associated Non-Coding RNAs.
MA554494 - JP 2018138019-A/126420: Polycomb-Associated Non-Coding RNAs.
LF318918 - JP 2014500723-A/126421: Polycomb-Associated Non-Coding RNAs.
MA554495 - JP 2018138019-A/126421: Polycomb-Associated Non-Coding RNAs.
JD109959 - Sequence 90983 from Patent EP1572962.
JD109960 - Sequence 90984 from Patent EP1572962.
JD223622 - Sequence 204646 from Patent EP1572962.
JD206224 - Sequence 187248 from Patent EP1572962.
JD113549 - Sequence 94573 from Patent EP1572962.
JD259729 - Sequence 240753 from Patent EP1572962.
JD259730 - Sequence 240754 from Patent EP1572962.
JD153201 - Sequence 134225 from Patent EP1572962.
JD161425 - Sequence 142449 from Patent EP1572962.
JD547455 - Sequence 528479 from Patent EP1572962.
JD048507 - Sequence 29531 from Patent EP1572962.
JD088897 - Sequence 69921 from Patent EP1572962.
JD113857 - Sequence 94881 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00040 - Pentose and glucuronate interconversions
hsa00053 - Ascorbate and aldarate metabolism
hsa00140 - Steroid hormone biosynthesis
hsa00500 - Starch and sucrose metabolism
hsa00830 - Retinol metabolism
hsa00860 - Porphyrin and chlorophyll metabolism
hsa00980 - Metabolism of xenobiotics by cytochrome P450
hsa00982 - Drug metabolism - cytochrome P450
hsa00983 - Drug metabolism - other enzymes
hsa01100 - Metabolic pathways

Reactome (by CSHL, EBI, and GO)

Protein Q9HAW8 (Reactome details) participates in the following event(s):

R-HSA-8941701 UGT1A10 transfers GlcA from UDP-GlcA to GCTN
R-HSA-156588 Glucuronidation
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-211859 Biological oxidations
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: GNT1, NM_019075, O00474, Q6NT91, Q9HAW8, uc002vur.1, uc002vur.2, uc002vur.3, uc002vur.4, UD110_HUMAN, UGT1
UCSC ID: uc002vur.4
RefSeq Accession: NM_019075
Protein: Q9HAW8 (aka UD110_HUMAN or UD1A_HUMAN)
CCDS: CCDS33403.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.