Human Gene MCRS1 (ENST00000343810.9) Description and Page Index
  Description: Homo sapiens microspherule protein 1 (MCRS1), transcript variant 1, mRNA. (from RefSeq NM_006337)
Gencode Transcript: ENST00000343810.9
Gencode Gene: ENSG00000187778.14
Transcript (Including UTRs)
   Position: hg38 chr12:49,558,299-49,568,142 Size: 9,844 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg38 chr12:49,558,643-49,566,731 Size: 8,089 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:49,558,299-49,568,142)mRNA (may differ from genome)Protein (462 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Microspherule protein 1; AltName: Full=58 kDa microspherule protein; AltName: Full=Cell cycle-regulated factor p78; AltName: Full=INO80 complex subunit J; AltName: Full=MCRS2;
FUNCTION: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity.
SUBUNIT: Binds to NOP2, DAXX, PINX1, TERT and Herpes simplex virus ICP22. Interacts with CCDC85B. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
INTERACTION: Q9Y3C0:CCDC53; NbExp=3; IntAct=EBI-348259, EBI-712969; Q9UER7:DAXX; NbExp=7; IntAct=EBI-348259, EBI-77321; Q8IXK0:PHC2; NbExp=2; IntAct=EBI-348259, EBI-713786;
SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Note=In microspherules in the nucleolus.
TISSUE SPECIFICITY: Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.
DEVELOPMENTAL STAGE: Cell-cycle regulated: levels are highest early in S phase; not detectable in G2.
SIMILARITY: Contains 1 FHA domain.
SEQUENCE CAUTION: Sequence=AAC68599.1; Type=Frameshift; Positions=Several;

-  MalaCards Disease Associations
  MalaCards Gene Search: MCRS1
Diseases sorted by gene-association score: herpes simplex (5), pigmented basal cell carcinoma (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.58 RPKM in Testis
Total median expression: 979.21 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -70.70205-0.345 Picture PostScript Text
3' UTR -119.40344-0.347 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000253 - FHA_dom
IPR025999 - MCRS_N
IPR008984 - SMAD_FHA_domain

Pfam Domains:
PF00498 - FHA domain
PF13325 - N-terminal region of micro-spherule protein

ModBase Predicted Comparative 3D Structure on Q96EZ8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0002151 G-quadruplex RNA binding
GO:0005515 protein binding
GO:0008266 poly(U) RNA binding
GO:0010521 telomerase inhibitor activity
GO:0034046 poly(G) binding
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046972 histone acetyltransferase activity (H4-K16 specific)

Biological Process:
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006464 cellular protein modification process
GO:0006974 cellular response to DNA damage stimulus
GO:0016579 protein deubiquitination
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation
GO:0051974 negative regulation of telomerase activity
GO:1904357 negative regulation of telomere maintenance via telomere lengthening
GO:1904751 positive regulation of protein localization to nucleolus

Cellular Component:
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005844 polysome
GO:0030425 dendrite
GO:0031011 Ino80 complex
GO:0043204 perikaryon
GO:0071339 MLL1 complex

-  Descriptions from all associated GenBank mRNAs
  LF210439 - JP 2014500723-A/17942: Polycomb-Associated Non-Coding RNAs.
MA446016 - JP 2018138019-A/17942: Polycomb-Associated Non-Coding RNAs.
LF206710 - JP 2014500723-A/14213: Polycomb-Associated Non-Coding RNAs.
MA442287 - JP 2018138019-A/14213: Polycomb-Associated Non-Coding RNAs.
BX538079 - Homo sapiens mRNA; cDNA DKFZp686N07218 (from clone DKFZp686N07218).
AF015308 - Homo sapiens nucleolar protein (MSP58) mRNA, complete cds.
BC011794 - Homo sapiens microspherule protein 1, mRNA (cDNA clone MGC:19577 IMAGE:4298118), complete cds.
AF068007 - Homo sapiens cell cycle-regulated factor p78 mRNA, complete cds.
JD065044 - Sequence 46068 from Patent EP1572962.
JD103970 - Sequence 84994 from Patent EP1572962.
JD191452 - Sequence 172476 from Patent EP1572962.
JD170021 - Sequence 151045 from Patent EP1572962.
JD460466 - Sequence 441490 from Patent EP1572962.
JD424634 - Sequence 405658 from Patent EP1572962.
JD431159 - Sequence 412183 from Patent EP1572962.
JD389655 - Sequence 370679 from Patent EP1572962.
JD517123 - Sequence 498147 from Patent EP1572962.
JD235570 - Sequence 216594 from Patent EP1572962.
JD550921 - Sequence 531945 from Patent EP1572962.
KJ893043 - Synthetic construct Homo sapiens clone ccsbBroadEn_02437 MCRS1 gene, encodes complete protein.
AY336730 - Homo sapiens MCRS2 mRNA, complete cds.
DQ892887 - Synthetic construct clone IMAGE:100005517; FLH190664.01X; RZPDo839C0976D microspherule protein 1 (MCRS1) gene, encodes complete protein.
EU176727 - Synthetic construct Homo sapiens clone IMAGE:100011522; FLH190663.01L; RZPDo839C08255D microspherule protein 1 (MCRS1) gene, encodes complete protein.
AB463118 - Synthetic construct DNA, clone: pF1KB5597, Homo sapiens MCRS1 gene for microspherule protein 1, without stop codon, in Flexi system.
AK308581 - Homo sapiens cDNA, FLJ98622.
LF337920 - JP 2014500723-A/145423: Polycomb-Associated Non-Coding RNAs.
MA573497 - JP 2018138019-A/145423: Polycomb-Associated Non-Coding RNAs.
LF357287 - JP 2014500723-A/164790: Polycomb-Associated Non-Coding RNAs.
MA592864 - JP 2018138019-A/164790: Polycomb-Associated Non-Coding RNAs.
CU680056 - Synthetic construct Homo sapiens gateway clone IMAGE:100019513 5' read MCRS1 mRNA.
LF357286 - JP 2014500723-A/164789: Polycomb-Associated Non-Coding RNAs.
MA592863 - JP 2018138019-A/164789: Polycomb-Associated Non-Coding RNAs.
LF337925 - JP 2014500723-A/145428: Polycomb-Associated Non-Coding RNAs.
MA573502 - JP 2018138019-A/145428: Polycomb-Associated Non-Coding RNAs.
LF357285 - JP 2014500723-A/164788: Polycomb-Associated Non-Coding RNAs.
MA592862 - JP 2018138019-A/164788: Polycomb-Associated Non-Coding RNAs.
LF337926 - JP 2014500723-A/145429: Polycomb-Associated Non-Coding RNAs.
MA573503 - JP 2018138019-A/145429: Polycomb-Associated Non-Coding RNAs.
LF337927 - JP 2014500723-A/145430: Polycomb-Associated Non-Coding RNAs.
MA573504 - JP 2018138019-A/145430: Polycomb-Associated Non-Coding RNAs.
LF357283 - JP 2014500723-A/164786: Polycomb-Associated Non-Coding RNAs.
MA592860 - JP 2018138019-A/164786: Polycomb-Associated Non-Coding RNAs.
JD043823 - Sequence 24847 from Patent EP1572962.
JD336102 - Sequence 317126 from Patent EP1572962.
AK123187 - Homo sapiens cDNA FLJ41193 fis, clone BRACE2045300, highly similar to COFILIN, NON-MUSCLE ISOFORM.
JD061606 - Sequence 42630 from Patent EP1572962.
JD436936 - Sequence 417960 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96EZ8 (Reactome details) participates in the following event(s):

R-HSA-5689544 UCHL5 binds INO80 complex
R-HSA-3321805 NSL acetylates histone H4
R-HSA-5689603 UCH proteinases
R-HSA-3214847 HATs acetylate histones
R-HSA-5688426 Deubiquitination
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-597592 Post-translational protein modification
R-HSA-4839726 Chromatin organization
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: INO80Q, MCRS1_HUMAN, MSP58, NM_006337, O14742, O75497, Q6VN53, Q96EZ8, uc001ruk.1, uc001ruk.2, uc001ruk.3, uc001ruk.4
UCSC ID: uc001ruk.4
RefSeq Accession: NM_006337
Protein: Q96EZ8 (aka MCRS1_HUMAN or MCS1_HUMAN)
CCDS: CCDS8787.1, CCDS31795.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.