Human Gene CTSL (ENST00000343150.10) Description and Page Index
Description: Homo sapiens cathepsin L (CTSL), transcript variant 1, mRNA. (from RefSeq NM_001912) RefSeq Summary (NM_001912): The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]. Gencode Transcript: ENST00000343150.10 Gencode Gene: ENSG00000135047.15 Transcript (Including UTRs) Position: hg38 chr9:87,726,119-87,731,469 Size: 5,351 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr9:87,727,604-87,731,107 Size: 3,504 Coding Exon Count: 7
ID:CATL1_HUMAN DESCRIPTION: RecName: Full=Cathepsin L1; EC=126.96.36.199; AltName: Full=Major excreted protein; Short=MEP; Contains: RecName: Full=Cathepsin L1 heavy chain; Contains: RecName: Full=Cathepsin L1 light chain; Flags: Precursor; FUNCTION: Important for the overall degradation of proteins in lysosomes. CATALYTIC ACTIVITY: Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg- NHMec, and no peptidyl-dipeptidase activity. SUBUNIT: Dimer of a heavy and a light chain linked by disulfide bonds. INTERACTION: G5EFH4:srp-6 (xeno); NbExp=2; IntAct=EBI-1220160, EBI-1549936; SUBCELLULAR LOCATION: Lysosome. SIMILARITY: Belongs to the peptidase C1 family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CTSL1ID40208ch9q21.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P07711
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002250 adaptive immune response GO:0006508 proteolysis GO:0019882 antigen processing and presentation GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0022617 extracellular matrix disassembly GO:0030574 collagen catabolic process GO:0045616 regulation of keratinocyte differentiation GO:0051603 proteolysis involved in cellular protein catabolic process GO:0071888 macrophage apoptotic process GO:0097067 cellular response to thyroid hormone stimulus