Human Gene ADGRL1 (ENST00000340736.10) Description and Page Index
Description: Homo sapiens adhesion G protein-coupled receptor L1 (ADGRL1), transcript variant 1, mRNA. (from RefSeq NM_001008701) RefSeq Summary (NM_001008701): This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]. Gencode Transcript: ENST00000340736.10 Gencode Gene: ENSG00000072071.16 Transcript (Including UTRs) Position: hg38 chr19:14,147,743-14,206,187 Size: 58,445 Total Exon Count: 24 Strand: - Coding Region Position: hg38 chr19:14,150,873-14,183,602 Size: 32,730 Coding Exon Count: 23
ID:LPHN1_HUMAN DESCRIPTION: RecName: Full=Latrophilin-1; AltName: Full=Calcium-independent alpha-latrotoxin receptor 1; Short=CIRL-1; AltName: Full=Lectomedin-2; Flags: Precursor; FUNCTION: Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity). SUBUNIT: Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with proteins of the SHANK family via the PDZ domain (By similarity). INTERACTION: O00555:CACNA1A; NbExp=2; IntAct=EBI-3389315, EBI-766279; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. DOMAIN: The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin (By similarity). PTM: Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus (By similarity). SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. SIMILARITY: Contains 1 GPS domain. SIMILARITY: Contains 1 olfactomedin-like domain. SIMILARITY: Contains 1 SUEL-type lectin domain. SEQUENCE CAUTION: Sequence=BAA74844.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O94910
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.