Human Gene PRIM1 (ENST00000338193.11) from GENCODE V44
Description: Homo sapiens DNA primase subunit 1 (PRIM1), mRNA. (from RefSeq NM_000946) RefSeq Summary (NM_000946): The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000338193.11 Gencode Gene: ENSG00000198056.16 Transcript (Including UTRs) Position: hg38 chr12:56,731,580-56,752,323 Size: 20,744 Total Exon Count: 13 Strand: - Coding Region Position: hg38 chr12:56,731,715-56,752,298 Size: 20,584 Coding Exon Count: 13
ID:PRI1_HUMAN DESCRIPTION: RecName: Full=DNA primase small subunit; EC=2.7.7.-; AltName: Full=DNA primase 49 kDa subunit; Short=p49; FUNCTION: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. SUBUNIT: Heterodimer of a small subunit and a large subunit. MISCELLANEOUS: The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (By similarity). SIMILARITY: Belongs to the eukaryotic-type primase small subunit family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49642
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000082 G1/S transition of mitotic cell cycle GO:0006260 DNA replication GO:0006269 DNA replication, synthesis of RNA primer GO:0032201 telomere maintenance via semi-conservative replication