Human Gene ZNF112 (ENST00000337401.8) Description and Page Index
  Description: Homo sapiens zinc finger protein 112 (ZNF112), transcript variant 1, mRNA. (from RefSeq NM_001083335)
Gencode Transcript: ENST00000337401.8
Gencode Gene: ENSG00000062370.16
Transcript (Including UTRs)
   Position: hg38 chr19:44,326,943-44,356,680 Size: 29,738 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr19:44,327,433-44,343,268 Size: 15,836 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:44,326,943-44,356,680)mRNA (may differ from genome)Protein (913 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsHGNCHPRD
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 112 homolog; Short=Zfp-112; AltName: Full=Zinc finger protein 228;
FUNCTION: May be involved in transcriptional regulation.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 17 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.29 RPKM in Testis
Total median expression: 16.58 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.7089-0.255 Picture PostScript Text
3' UTR -100.00490-0.204 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF01352 - KRAB box

ModBase Predicted Comparative 3D Structure on Q9UJU3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AL122078 - Homo sapiens mRNA; cDNA DKFZp434J0650 (from clone DKFZp434J0650); partial cds.
AK026230 - Homo sapiens cDNA: FLJ22577 fis, clone HSI02514, highly similar to AF198358 Homo sapiens zinc finger protein ZNF228 (ZNF228) mRNA.
AF198358 - Homo sapiens zinc finger protein ZNF228 (ZNF228) mRNA, complete cds.
AK023099 - Homo sapiens cDNA FLJ13037 fis, clone NT2RP3001268, highly similar to Zinc finger protein 228.
AK130371 - Homo sapiens cDNA FLJ26861 fis, clone PRS08385, highly similar to Zinc finger protein 228.
JD410350 - Sequence 391374 from Patent EP1572962.
JD559151 - Sequence 540175 from Patent EP1572962.
JD507071 - Sequence 488095 from Patent EP1572962.
JD532052 - Sequence 513076 from Patent EP1572962.
JD302437 - Sequence 283461 from Patent EP1572962.
AK302966 - Homo sapiens cDNA FLJ55602 complete cds, highly similar to Zinc finger protein 228.
JD435840 - Sequence 416864 from Patent EP1572962.
JD550452 - Sequence 531476 from Patent EP1572962.
BC101753 - Homo sapiens zinc finger protein 112 homolog (mouse), mRNA (cDNA clone MGC:126802 IMAGE:8069259), complete cds.
BC117223 - Homo sapiens zinc finger protein 112 homolog (mouse), mRNA (cDNA clone MGC:150832 IMAGE:40125774), complete cds.
AK302594 - Homo sapiens cDNA FLJ55559 complete cds, highly similar to Zinc finger protein 228.
HQ258527 - Synthetic construct Homo sapiens clone IMAGE:100072956 zinc finger protein 112 homolog (mouse) (ZFP112), transcript variant 2 (ZFP112) gene, encodes complete protein.
KJ897784 - Synthetic construct Homo sapiens clone ccsbBroadEn_07178 ZFP112 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UJU3 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A4FU53, NM_001083335, Q9HCA7, Q9UJU3, uc010ejj.1, uc010ejj.2, uc010ejj.3, uc010ejj.4, ZF112_HUMAN, ZFP112, ZNF228
UCSC ID: uc010ejj.4
RefSeq Accession: NM_001083335
Protein: Q9UJU3 (aka ZF112_HUMAN)
CCDS: CCDS12637.1, CCDS54276.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.