Human Gene ZNF112 (ENST00000337401.8) Description and Page Index
  Description: Homo sapiens zinc finger protein 112 (ZNF112), transcript variant 1, mRNA. (from RefSeq NM_001083335)
Gencode Transcript: ENST00000337401.8
Gencode Gene: ENSG00000062370.16
Transcript (Including UTRs)
   Position: hg38 chr19:44,326,943-44,356,680 Size: 29,738 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr19:44,327,433-44,343,268 Size: 15,836 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:44,326,943-44,356,680)mRNA (may differ from genome)Protein (913 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsHGNCHPRD
LynxMGIneXtProtOMIMPubMedReactome
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ZF112_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 112 homolog; Short=Zfp-112; AltName: Full=Zinc finger protein 228;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 17 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.29 RPKM in Testis
Total median expression: 16.58 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.7089-0.255 Picture PostScript Text
3' UTR -100.00490-0.204 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF01352 - KRAB box

ModBase Predicted Comparative 3D Structure on Q9UJU3
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AL122078 - Homo sapiens mRNA; cDNA DKFZp434J0650 (from clone DKFZp434J0650); partial cds.
AK026230 - Homo sapiens cDNA: FLJ22577 fis, clone HSI02514, highly similar to AF198358 Homo sapiens zinc finger protein ZNF228 (ZNF228) mRNA.
AF198358 - Homo sapiens zinc finger protein ZNF228 (ZNF228) mRNA, complete cds.
AK023099 - Homo sapiens cDNA FLJ13037 fis, clone NT2RP3001268, highly similar to Zinc finger protein 228.
AK130371 - Homo sapiens cDNA FLJ26861 fis, clone PRS08385, highly similar to Zinc finger protein 228.
JD410350 - Sequence 391374 from Patent EP1572962.
JD559151 - Sequence 540175 from Patent EP1572962.
JD507071 - Sequence 488095 from Patent EP1572962.
JD532052 - Sequence 513076 from Patent EP1572962.
JD302437 - Sequence 283461 from Patent EP1572962.
AK302966 - Homo sapiens cDNA FLJ55602 complete cds, highly similar to Zinc finger protein 228.
JD435840 - Sequence 416864 from Patent EP1572962.
JD550452 - Sequence 531476 from Patent EP1572962.
BC101753 - Homo sapiens zinc finger protein 112 homolog (mouse), mRNA (cDNA clone MGC:126802 IMAGE:8069259), complete cds.
BC117223 - Homo sapiens zinc finger protein 112 homolog (mouse), mRNA (cDNA clone MGC:150832 IMAGE:40125774), complete cds.
AK302594 - Homo sapiens cDNA FLJ55559 complete cds, highly similar to Zinc finger protein 228.
HQ258527 - Synthetic construct Homo sapiens clone IMAGE:100072956 zinc finger protein 112 homolog (mouse) (ZFP112), transcript variant 2 (ZFP112) gene, encodes complete protein.
KJ897784 - Synthetic construct Homo sapiens clone ccsbBroadEn_07178 ZFP112 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UJU3 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A4FU53, NM_001083335, Q9HCA7, Q9UJU3, uc010ejj.1, uc010ejj.2, uc010ejj.3, uc010ejj.4, ZF112_HUMAN, ZFP112, ZNF228
UCSC ID: uc010ejj.4
RefSeq Accession: NM_001083335
Protein: Q9UJU3 (aka ZF112_HUMAN)
CCDS: CCDS12637.1, CCDS54276.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.