Human Gene ATP5MD (ENST00000337003.4) Description and Page Index
  Description: Homo sapiens ATP synthase membrane subunit DAPIT (ATP5MD), transcript variant 2, mRNA. (from RefSeq NM_032747)
Gencode Transcript: ENST00000337003.4
Gencode Gene: ENSG00000173915.16
Transcript (Including UTRs)
   Position: hg38 chr10:103,389,050-103,396,466 Size: 7,417 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr10:103,392,194-103,392,457 Size: 264 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:103,389,050-103,396,466)mRNA (may differ from genome)Protein (58 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGeneCardsHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: USMG5_HUMAN
DESCRIPTION: RecName: Full=Up-regulated during skeletal muscle growth protein 5; AltName: Full=Diabetes-associated protein in insulin-sensitive tissues; AltName: Full=HCV F-transactivated protein 2;
FUNCTION: Plays a critical role in maintaining the ATP synthase population in mitochondria.
SUBUNIT: Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).
SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane protein (By similarity).
INDUCTION: Transactivated by SBP1.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 115.72 RPKM in Heart - Left Ventricle
Total median expression: 2645.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -80.60263-0.306 Picture PostScript Text
3' UTR -16.40120-0.137 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009125 - DAPIT

ModBase Predicted Comparative 3D Structure on Q96IX5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005739 mitochondrion
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane


-  Descriptions from all associated GenBank mRNAs
  AL110185 - Homo sapiens mRNA; cDNA DKFZp566D211 (from clone DKFZp566D211).
BC091507 - Homo sapiens up-regulated during skeletal muscle growth 5 homolog (mouse), mRNA (cDNA clone MGC:111165 IMAGE:30417704), complete cds.
BC072683 - Homo sapiens up-regulated during skeletal muscle growth 5 homolog (mouse), mRNA (cDNA clone MGC:87882 IMAGE:6056764), complete cds.
AJ272056 - Homo sapiens mRNA for hypothetical protein (PD04912).
BC007087 - Homo sapiens up-regulated during skeletal muscle growth 5 homolog (mouse), mRNA (cDNA clone MGC:14697 IMAGE:4245636), complete cds.
AY740522 - Homo sapiens HCV F-transactivated protein 2 mRNA, complete cds.
AK311888 - Homo sapiens cDNA, FLJ92154, Homo sapiens upregulated during skeletal muscle growth 5 (USMG5),mRNA.
KJ895035 - Synthetic construct Homo sapiens clone ccsbBroadEn_04429 USMG5 gene, encodes complete protein.
HZ408926 - JP 2015528002-A/1523: CHIRAL CONTROL.
HZ462117 - WO 2015190591-A/272: Kit and method for detecting breast cancer.
HZ464160 - WO 2015194610-A/596: Kit and method for detecting lung cancer.
LG052260 - KR 1020150036642-A/1526: CHIRAL CONTROL.
LY498061 - KR 1020170018409-A/596: KIT OR DEVICE FOR DETECTING LUNG CANCER, AND LUNG CANCER DETECTION METHOD.
LY499120 - KR 1020170018412-A/272: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER.
MS880435 - Sequence 272 from Patent EP3156498.
MS997127 - Sequence 596 from Patent EP3159416.
DL491682 - Novel nucleic acids.
DL491232 - Novel nucleic acids.
HZ462394 - WO 2015190591-A/549: Kit and method for detecting breast cancer.
HZ464181 - WO 2015194610-A/617: Kit and method for detecting lung cancer.
LY498082 - KR 1020170018409-A/617: KIT OR DEVICE FOR DETECTING LUNG CANCER, AND LUNG CANCER DETECTION METHOD.
LY499397 - KR 1020170018412-A/549: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER.
MS880712 - Sequence 549 from Patent EP3156498.
MS997148 - Sequence 617 from Patent EP3159416.
DL489878 - Novel nucleic acids.
FZ414511 - WO 2011007815-A/401: A method for screening a food which promotes production of milk having immunoregulating effect.
HI965465 - Sequence 750 from Patent WO2010139812.
HI966441 - Sequence 761 from Patent WO2010139811.
HI967307 - Sequence 761 from Patent WO2010139810.
HV594868 - JP 2010539959-A/249: Micromirs.
HV822039 - JP 2011140513-A/401: An Immunostimulating pharmaceutical composition, and a method for producing the immunostimulating pharmaceutical composition.
HZ074747 - JP 2013535982-A/838: Single-Stranded RNAi Agents Containing an Internal, Non-Nucleic Acid Spacer.
HZ082767 - JP 2015513906-A/124: Stem Cell Microparticles.
HZ157425 - JP 2015130862-A/249: Micromirs.
HZ436548 - JP 2015529450-A/124: Stem Cell Microparticles.
HZ461848 - WO 2015190591-A/3: Kit and method for detecting breast cancer.
HZ464143 - WO 2015194610-A/579: Kit and method for detecting lung cancer.
HZ479772 - JP 2015535430-A/278: TERMINALLY MODIFIED RNA.
HZ789703 - JP 2016504050-A/1448: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JA401503 - Sequence 750 from Patent WO2011080318.
JA402481 - Sequence 750 from Patent WO2011080315.
JA403488 - Sequence 750 from Patent WO2011080316.
JA406119 - Sequence 750 from Patent EP2336353.
JA429645 - Sequence 750 from Patent WO2011095623.
JB022382 - Sequence 224 from Patent WO2013026685.
JB023090 - Sequence 344 from Patent WO2013026684.
JB073537 - Sequence 10 from Patent EP2546361.
JB149326 - Sequence 401 from Patent EP2455486.
JB620932 - Sequence 912 from Patent WO2013063544.
JC171752 - Sequence 124 from Patent WO2013150303.
JC512435 - Sequence 2688 from Patent WO2014113089.
JC572563 - Sequence 124 from Patent WO2014125276.
JC582251 - Sequence 124 from Patent WO2014125277.
JE953947 - Sequence 124 from Patent WO2015052526.
JE955700 - Sequence 124 from Patent WO2015052527.
LF137452 - JP 2016507550-A/124: Method of Producing Microparticles.
LF160326 - JP 2016513950-A/392: Oligomers with improved off-target profile.
LF162417 - JP 2016513095-A/124: Stem Cell Microparticles and miRNA.
LF953169 - JP 2016534103-A/124: Stem Cell Microparticles and miRNA.
LG005514 - KR 1020150004822-A/124: STEM CELL MICROPARTICLES.
LG053210 - KR 1020150059168-A/124: STEM CELL MICROPARTICLES.
LG240449 - KR 1020160035087-A/124: STEM CELL MICROPARTICLES AND MIRNA.
LP727067 - Sequence 761 from Patent EP2883966.
LP819337 - Sequence 761 from Patent EP3296406.
LP939279 - Sequence 761 from Patent EP3184651.
LP951875 - Sequence 381 from Patent WO2017157650.
LQ070023 - Sequence 347 from Patent EP2964234.
LV470534 - JP 2016534036-A/124: Stem Cell Microparticles and miRNA.
LY404933 - KR 1020160117535-A/238: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES.
LY498044 - KR 1020170018409-A/579: KIT OR DEVICE FOR DETECTING LUNG CANCER, AND LUNG CANCER DETECTION METHOD.
LY498851 - KR 1020170018412-A/3: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER.
MA260172 - JP 2017505623-A/238: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES.
MA267297 - JP 2018061445-A/31: Method for detecting urothelial cancer based on microRNA in urine using cell sorting.
MA643524 - JP 2017113010-A/1448: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA731408 - JP 2017140048-A/278: TERMINALLY MODIFIED RNA.
MA765520 - JP 2017514519-A/86: Small ncRNAs as biomarkers.
MS673541 - Sequence 344 from Patent EP3135774.
MS834604 - Sequence 750 from Patent EP3112479.
MS880166 - Sequence 3 from Patent EP3156498.
MS901751 - Sequence 224 from Patent EP3156505.
MS997110 - Sequence 579 from Patent EP3159416.
HZ082734 - JP 2015513906-A/91: Stem Cell Microparticles.
HZ436515 - JP 2015529450-A/91: Stem Cell Microparticles.
HZ479773 - JP 2015535430-A/279: TERMINALLY MODIFIED RNA.
HZ789704 - JP 2016504050-A/1449: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JC171719 - Sequence 91 from Patent WO2013150303.
JC512436 - Sequence 2689 from Patent WO2014113089.
JC572530 - Sequence 91 from Patent WO2014125276.
JC582218 - Sequence 91 from Patent WO2014125277.
JE953914 - Sequence 91 from Patent WO2015052526.
JE955667 - Sequence 91 from Patent WO2015052527.
LF137419 - JP 2016507550-A/91: Method of Producing Microparticles.
LF161744 - JP 2016513950-A/1810: Oligomers with improved off-target profile.
LF162384 - JP 2016513095-A/91: Stem Cell Microparticles and miRNA.
LF644452 - JP 2016144439-A/43: Method for assessing cell aging.
LF953136 - JP 2016534103-A/91: Stem Cell Microparticles and miRNA.
LG005481 - KR 1020150004822-A/91: STEM CELL MICROPARTICLES.
LG053177 - KR 1020150059168-A/91: STEM CELL MICROPARTICLES.
LG240416 - KR 1020160035087-A/91: STEM CELL MICROPARTICLES AND MIRNA.
LP951800 - Sequence 306 from Patent WO2017157650.
LQ070024 - Sequence 348 from Patent EP2964234.
LV470501 - JP 2016534036-A/91: Stem Cell Microparticles and miRNA.
MA643525 - JP 2017113010-A/1449: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA731409 - JP 2017140048-A/279: TERMINALLY MODIFIED RNA.
MP015384 - Sequence 587 from Patent WO2019016252.
DL490266 - Novel nucleic acids.
MA806023 - WO 2018199275-A/283: Kit, device and method for detection of ovary tumor.
MA806294 - WO 2018199275-A/554: Kit, device and method for detection of ovary tumor.
MA800577 - JP 2018183181-A/1448: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA805748 - WO 2018199275-A/8: Kit, device and method for detection of ovary tumor.
MA800578 - JP 2018183181-A/1449: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA822828 - WO 2019004436-A/641: Kit, device, and method for detection of lung cancer.
MA823163 - WO 2019004436-A/976: Kit, device, and method for detection of lung cancer.
MA822496 - WO 2019004436-A/309: Kit, device, and method for detection of lung cancer.
MA848618 - JP 2019017383-A/17: SHORT-CHAIN NUCLEIC ACID ELONGATION PRIMER SET, ASSAY KIT,AND SHORT-CHAIN NUCLEIC ACID ELONGATION, AMPLIFICATION AND DETECTION METHODS.
MP129224 - Sequence 124 from Patent EP3470073.
MP162147 - Sequence 124 from Patent WO2019069093.
MP129191 - Sequence 91 from Patent EP3470073.
MP162114 - Sequence 91 from Patent WO2019069093.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R4N2, D3DR92, DAPIT, HCVFTP2, NM_032747, PD04912, Q96IX5, uc001kww.1, uc001kww.2, uc001kww.3, uc001kww.4, USMG5, USMG5_HUMAN
UCSC ID: uc001kww.4
RefSeq Accession: NM_032747
Protein: Q96IX5 (aka USMG5_HUMAN)
CCDS: CCDS7548.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.