Human Gene RTN4RL2 (ENST00000335099.8) Description and Page Index
  Description: Homo sapiens reticulon 4 receptor like 2 (RTN4RL2), mRNA. (from RefSeq NM_178570)
Gencode Transcript: ENST00000335099.8
Gencode Gene: ENSG00000186907.8
Transcript (Including UTRs)
   Position: hg38 chr11:57,460,528-57,477,534 Size: 17,007 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr11:57,460,866-57,476,911 Size: 16,046 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:57,460,528-57,477,534)mRNA (may differ from genome)Protein (420 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
ReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Reticulon-4 receptor-like 2; AltName: Full=Nogo receptor-like 3; AltName: Full=Nogo-66 receptor homolog 1; AltName: Full=Nogo-66 receptor-related protein 2; Short=NgR2; Flags: Precursor;
FUNCTION: May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized to the surface of neurons, including axons.
TISSUE SPECIFICITY: Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.
PTM: Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.
SIMILARITY: Belongs to the Nogo receptor family.
SIMILARITY: Contains 8 LRR (leucine-rich) repeats.
SIMILARITY: Contains 1 LRRCT domain.
SIMILARITY: Contains 1 LRRNT domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.81 RPKM in Thyroid
Total median expression: 144.89 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -182.50338-0.540 Picture PostScript Text
3' UTR -240.70623-0.386 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000483 - Cys-rich_flank_reg_C
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR000372 - LRR-contain_N

ModBase Predicted Comparative 3D Structure on Q86UN3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004860 protein kinase inhibitor activity
GO:0038023 signaling receptor activity

Biological Process:
GO:0006469 negative regulation of protein kinase activity
GO:0007166 cell surface receptor signaling pathway
GO:0010977 negative regulation of neuron projection development
GO:0019221 cytokine-mediated signaling pathway
GO:0022038 corpus callosum development
GO:0031103 axon regeneration
GO:0046426 negative regulation of JAK-STAT cascade

Cellular Component:
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0031225 anchored component of membrane
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043204 perikaryon
GO:0045121 membrane raft
GO:0046658 anchored component of plasma membrane
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  JD038981 - Sequence 20005 from Patent EP1572962.
JD129207 - Sequence 110231 from Patent EP1572962.
BC113673 - Homo sapiens reticulon 4 receptor-like 2, mRNA (cDNA clone MGC:142233 IMAGE:8322725), complete cds.
BC117276 - Homo sapiens reticulon 4 receptor-like 2, mRNA (cDNA clone MGC:150885 IMAGE:40125827), complete cds.
BC143818 - Homo sapiens reticulon 4 receptor-like 2, mRNA (cDNA clone MGC:177350 IMAGE:9052333), complete cds.
DQ864979 - Homo sapiens RTN4RL2 mRNA, complete cds, alternatively spliced.
AF532858 - Homo sapiens Nogo-66 receptor homolog-1 (NGRH1) mRNA, complete cds.
AX751514 - Sequence 1 from Patent WO03035687.
AY250221 - Homo sapiens nogo receptor-like 3 (NGRL3) mRNA, complete cds.
JD199803 - Sequence 180827 from Patent EP1572962.
JD190966 - Sequence 171990 from Patent EP1572962.
JD365416 - Sequence 346440 from Patent EP1572962.
JD380234 - Sequence 361258 from Patent EP1572962.
JD306954 - Sequence 287978 from Patent EP1572962.
JD164609 - Sequence 145633 from Patent EP1572962.
JD049385 - Sequence 30409 from Patent EP1572962.
JD431418 - Sequence 412442 from Patent EP1572962.
JD479674 - Sequence 460698 from Patent EP1572962.
JD477538 - Sequence 458562 from Patent EP1572962.
JD426983 - Sequence 408007 from Patent EP1572962.
JD514221 - Sequence 495245 from Patent EP1572962.
JD105431 - Sequence 86455 from Patent EP1572962.
JD322817 - Sequence 303841 from Patent EP1572962.
JD380232 - Sequence 361256 from Patent EP1572962.
JD532097 - Sequence 513121 from Patent EP1572962.
JD306625 - Sequence 287649 from Patent EP1572962.
JD412935 - Sequence 393959 from Patent EP1572962.
JD064807 - Sequence 45831 from Patent EP1572962.
JD483247 - Sequence 464271 from Patent EP1572962.
JD479669 - Sequence 460693 from Patent EP1572962.
JD254223 - Sequence 235247 from Patent EP1572962.
JD461818 - Sequence 442842 from Patent EP1572962.
JD190956 - Sequence 171980 from Patent EP1572962.
JD128253 - Sequence 109277 from Patent EP1572962.
JD139367 - Sequence 120391 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86UN3 (Reactome details) participates in the following event(s):

R-HSA-8940388 GPLD1 hydrolyses GPI-anchors from proteins
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: NGRH1, NGRL3, NM_178570, Q17RL9, Q6X813, Q86UN3, R4RL2_HUMAN, uc010rjt.1, uc010rjt.2, uc010rjt.3, uc010rjt.4, uc010rjt.5
UCSC ID: uc010rjt.5
RefSeq Accession: NM_178570
Protein: Q86UN3 (aka R4RL2_HUMAN)
CCDS: CCDS7957.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.