Human Gene VDAC2 (ENST00000332211.10) Description and Page Index
Description: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. (from UniProt P45880) RefSeq Summary (NM_003375): This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]. Gencode Transcript: ENST00000332211.10 Gencode Gene: ENSG00000165637.13 Transcript (Including UTRs) Position: hg38 chr10:75,210,751-75,231,448 Size: 20,698 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr10:75,211,159-75,230,989 Size: 19,831 Coding Exon Count: 9
ID:VDAC2_HUMAN DESCRIPTION: RecName: Full=Voltage-dependent anion-selective channel protein 2; Short=VDAC-2; Short=hVDAC2; AltName: Full=Outer mitochondrial membrane protein porin 2; FUNCTION: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. SUBUNIT: Interacts with hexokinases (By similarity). INTERACTION: Q96A26:FAM162A; NbExp=2; IntAct=EBI-354022, EBI-6123466; SUBCELLULAR LOCATION: Mitochondrion outer membrane. TISSUE SPECIFICITY: Expressed in all tissues examined. DOMAIN: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (By similarity). SIMILARITY: Belongs to the eukaryotic mitochondrial porin family. SEQUENCE CAUTION: Sequence=CAH73106.1; Type=Erroneous gene model prediction; Sequence=CAI40910.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P45880
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.