Human Gene VDAC2 (ENST00000332211.10) Description and Page Index
  Description: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. (from UniProt P45880)
RefSeq Summary (NM_003375): This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
Gencode Transcript: ENST00000332211.10
Gencode Gene: ENSG00000165637.13
Transcript (Including UTRs)
   Position: hg38 chr10:75,210,751-75,231,448 Size: 20,698 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg38 chr10:75,211,159-75,230,989 Size: 19,831 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:75,210,751-75,231,448)mRNA (may differ from genome)Protein (294 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCHPRD
LynxMGIneXtProtPubMedReactomeStanford SOURCE
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: VDAC2_HUMAN
DESCRIPTION: RecName: Full=Voltage-dependent anion-selective channel protein 2; Short=VDAC-2; Short=hVDAC2; AltName: Full=Outer mitochondrial membrane protein porin 2;
FUNCTION: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective.
SUBUNIT: Interacts with hexokinases (By similarity).
INTERACTION: Q96A26:FAM162A; NbExp=2; IntAct=EBI-354022, EBI-6123466;
SUBCELLULAR LOCATION: Mitochondrion outer membrane.
TISSUE SPECIFICITY: Expressed in all tissues examined.
DOMAIN: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (By similarity).
SIMILARITY: Belongs to the eukaryotic mitochondrial porin family.
SEQUENCE CAUTION: Sequence=CAH73106.1; Type=Erroneous gene model prediction; Sequence=CAI40910.1; Type=Erroneous gene model prediction;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 73.99 RPKM in Heart - Left Ventricle
Total median expression: 1871.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -103.20213-0.485 Picture PostScript Text
3' UTR -102.00459-0.222 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001925 - Porin_Euk

Pfam Domains:
PF01459 - Eukaryotic porin

ModBase Predicted Comparative 3D Structure on P45880
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD Ensembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0008308 voltage-gated anion channel activity
GO:0015288 porin activity

Biological Process:
GO:0006811 ion transport
GO:0006820 anion transport
GO:0007339 binding of sperm to zona pellucida
GO:0015698 inorganic anion transport
GO:0032272 negative regulation of protein polymerization
GO:0055085 transmembrane transport
GO:0098656 anion transmembrane transport
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Cellular Component:
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042645 mitochondrial nucleoid
GO:0043209 myelin sheath
GO:0045121 membrane raft
GO:0046930 pore complex


-  Descriptions from all associated GenBank mRNAs
  LF209960 - JP 2014500723-A/17463: Polycomb-Associated Non-Coding RNAs.
MA445537 - JP 2018138019-A/17463: Polycomb-Associated Non-Coding RNAs.
LF384970 - JP 2014500723-A/192473: Polycomb-Associated Non-Coding RNAs.
MA620547 - JP 2018138019-A/192473: Polycomb-Associated Non-Coding RNAs.
BC000165 - Homo sapiens voltage-dependent anion channel 2, mRNA (cDNA clone MGC:5237 IMAGE:2901130), complete cds.
BC072407 - Homo sapiens voltage-dependent anion channel 2, mRNA (cDNA clone MGC:88006 IMAGE:6137879), complete cds.
AK315919 - Homo sapiens cDNA, FLJ78818 complete cds, highly similar to Voltage-dependent anion-selective channel protein 2.
AK296635 - Homo sapiens cDNA FLJ60120 complete cds, highly similar to Voltage-dependent anion-selective channel protein 2.
DL492311 - Novel nucleic acids.
BC012883 - Homo sapiens voltage-dependent anion channel 2, mRNA (cDNA clone MGC:21498 IMAGE:3875077), complete cds.
L08666 - Homo sapiens porin (por) mRNA, complete cds and truncated cds.
DL490804 - Novel nucleic acids.
LF333488 - JP 2014500723-A/140991: Polycomb-Associated Non-Coding RNAs.
MA569065 - JP 2018138019-A/140991: Polycomb-Associated Non-Coding RNAs.
L06328 - Human voltage-dependent anion channel isoform 2 (VDAC) mRNA, complete cds.
CU687220 - Synthetic construct Homo sapiens gateway clone IMAGE:100022897 5' read VDAC2 mRNA.
KJ892371 - Synthetic construct Homo sapiens clone ccsbBroadEn_01765 VDAC2 gene, encodes complete protein.
GQ891299 - Homo sapiens clone HEL-S-22a epididymis secretory sperm binding protein mRNA, complete cds.
DQ894097 - Synthetic construct Homo sapiens clone IMAGE:100008557; FLH167656.01L; RZPDo839D0889D voltage-dependent anion channel 2 (VDAC2) gene, encodes complete protein.
DQ890934 - Synthetic construct clone IMAGE:100003564; FLH167660.01X; RZPDo839D0890D voltage-dependent anion channel 2 (VDAC2) gene, encodes complete protein.
CR456964 - Homo sapiens full open reading frame cDNA clone RZPDo834B065D for gene VDAC2, voltage-dependent anion channel 2; complete cds, incl. stopcodon.
CU680428 - Synthetic construct Homo sapiens gateway clone IMAGE:100016967 5' read VDAC2 mRNA.
KJ905949 - Synthetic construct Homo sapiens clone ccsbBroadEn_15619 VDAC2 gene, encodes complete protein.
LF358965 - JP 2014500723-A/166468: Polycomb-Associated Non-Coding RNAs.
MA594542 - JP 2018138019-A/166468: Polycomb-Associated Non-Coding RNAs.
LF333493 - JP 2014500723-A/140996: Polycomb-Associated Non-Coding RNAs.
MA569070 - JP 2018138019-A/140996: Polycomb-Associated Non-Coding RNAs.
LF358964 - JP 2014500723-A/166467: Polycomb-Associated Non-Coding RNAs.
MA594541 - JP 2018138019-A/166467: Polycomb-Associated Non-Coding RNAs.
LF358963 - JP 2014500723-A/166466: Polycomb-Associated Non-Coding RNAs.
MA594540 - JP 2018138019-A/166466: Polycomb-Associated Non-Coding RNAs.
LF333494 - JP 2014500723-A/140997: Polycomb-Associated Non-Coding RNAs.
MA569071 - JP 2018138019-A/140997: Polycomb-Associated Non-Coding RNAs.
JD313731 - Sequence 294755 from Patent EP1572962.
JD511189 - Sequence 492213 from Patent EP1572962.
LF333495 - JP 2014500723-A/140998: Polycomb-Associated Non-Coding RNAs.
MA569072 - JP 2018138019-A/140998: Polycomb-Associated Non-Coding RNAs.
JD296410 - Sequence 277434 from Patent EP1572962.
JD499075 - Sequence 480099 from Patent EP1572962.
JD252242 - Sequence 233266 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04020 - Calcium signaling pathway
hsa05012 - Parkinson's disease
hsa05016 - Huntington's disease

Reactome (by CSHL, EBI, and GO)

Protein P45880 (Reactome details) participates in the following event(s):

R-HSA-8949145 VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space
R-HSA-5696872 USP30 deubiquitinates Ub-MOM proteins
R-HSA-8949215 Mitochondrial calcium ion transport
R-HSA-5689880 Ub-specific processing proteases
R-HSA-382551 Transport of small molecules
R-HSA-5688426 Deubiquitination
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: BC000165, P45880, Q5VWK1, Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6, uc001jwz.1, uc001jwz.2, uc001jwz.3, uc001jwz.4, uc001jwz.5, VDAC2_HUMAN
UCSC ID: uc001jwz.5
RefSeq Accession: NM_003375
Protein: P45880 (aka VDAC2_HUMAN or POR2_HUMAN)
CCDS: CCDS7348.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.