Human Gene GPR39 (ENST00000329321.4) Description and Page Index
  Description: Homo sapiens G protein-coupled receptor 39 (GPR39), mRNA. (from RefSeq NM_001508)
RefSeq Summary (NM_001508): This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.30507.1, AK122643.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000329321.4/ ENSP00000327417.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000329321.4
Gencode Gene: ENSG00000183840.7
Transcript (Including UTRs)
   Position: hg38 chr2:132,416,805-132,646,582 Size: 229,778 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr2:132,417,043-132,645,606 Size: 228,564 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:132,416,805-132,646,582)mRNA (may differ from genome)Protein (453 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: GPR39_HUMAN
DESCRIPTION: RecName: Full=G-protein coupled receptor 39;
FUNCTION: Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in many tissues, including the stomach, intestine and hypothalamus.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.66 RPKM in Colon - Transverse
Total median expression: 10.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -68.20238-0.287 Picture PostScript Text
3' UTR -313.10976-0.321 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on O43194
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0046872 metal ion binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK122643 - Homo sapiens cDNA FLJ16071 fis, clone HSYRA2001003, highly similar to Probable G-protein coupled receptor 39.
AK314895 - Homo sapiens cDNA, FLJ95798, highly similar to Homo sapiens G protein-coupled receptor 39 (GPR39), mRNA.
AB527984 - Synthetic construct DNA, clone: pF1KE0606, Homo sapiens GPR39 gene for G protein-coupled receptor 39, without stop codon, in Flexi system.
KJ891285 - Synthetic construct Homo sapiens clone ccsbBroadEn_00679 GPR39 gene, encodes complete protein.
AF034633 - Homo sapiens orphan G protein-coupled receptor (GPR39) mRNA, complete cds.
FJ348258 - Homo sapiens G protein-coupled receptor 39 (GPR39) mRNA, complete cds.
BC125046 - Homo sapiens G protein-coupled receptor 39, mRNA (cDNA clone MGC:149541 IMAGE:40116106), complete cds.
BC125047 - Homo sapiens G protein-coupled receptor 39, mRNA (cDNA clone IMAGE:40116108), partial cds.
AK123759 - Homo sapiens cDNA FLJ41765 fis, clone IMR322006012, highly similar to Probable G-protein coupled receptor 39.
EU076432 - Homo sapiens G-protein coupled receptor 39-1b mRNA, complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O43194 (Reactome details) participates in the following event(s):

R-HSA-444572 Zinc is an agonist of GPR39
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418555 G alpha (s) signalling events
R-HSA-416476 G alpha (q) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2RC12, B6V9G4, GPR39_HUMAN, NM_001508, O43194, Q08AS2, Q53R01, uc002ttl.1, uc002ttl.2, uc002ttl.3, uc002ttl.4, uc002ttl.5
UCSC ID: uc002ttl.5
RefSeq Accession: NM_001508
Protein: O43194 (aka GPR39_HUMAN or GP39_HUMAN)
CCDS: CCDS2170.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.