Human Gene SULT1C3 (ENST00000329106.2) Description and Page Index
  Description: Homo sapiens sulfotransferase family 1C member 3 (SULT1C3), transcript variant 2, mRNA. (from RefSeq NM_001008743)
Gencode Transcript: ENST00000329106.2
Gencode Gene: ENSG00000196228.3
Transcript (Including UTRs)
   Position: hg38 chr2:108,247,195-108,265,351 Size: 18,157 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr2:108,247,195-108,265,351 Size: 18,157 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:108,247,195-108,265,351)mRNA (may differ from genome)Protein (304 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCHPRD
LynxMGIneXtProtOMIMPubMedStanford SOURCE
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ST1C3_HUMAN
DESCRIPTION: RecName: Full=Sulfotransferase 1C3; Short=ST1C3; EC=2.8.2.2;
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.
CATALYTIC ACTIVITY: 3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Not detectable in any of the tissues tested.
SIMILARITY: Belongs to the sulfotransferase 1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.61 RPKM in Small Intestine - Terminal Ileum
Total median expression: 1.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000863 - Sulfotransferase_dom

Pfam Domains:
PF00685 - Sulfotransferase domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2H8K
- X-ray MuPIT

2REO
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q6IMI6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004027 alcohol sulfotransferase activity
GO:0004062 aryl sulfotransferase activity
GO:0008146 sulfotransferase activity
GO:0016740 transferase activity

Biological Process:
GO:0006790 sulfur compound metabolic process

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AB528243 - Synthetic construct DNA, clone: pF1KE0229, Homo sapiens SULT1C3 gene for sulfotransferase family, cytosolic, 1C, member 3, without stop codon, in Flexi system.
BC146362 - Synthetic construct Homo sapiens clone IMAGE:100015215, MGC:180250 sulfotransferase family, cytosolic, 1C, member 3 (SULT1C3) mRNA, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001008743, Q6IMI5, Q6IMI6, ST1C3_HUMAN, uc010ywo.1, uc010ywo.2
UCSC ID: uc010ywo.2
RefSeq Accession: NM_001008743
Protein: Q6IMI6 (aka ST1C3_HUMAN)
CCDS: CCDS33267.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.