Human Gene PRMT9 (ENST00000322396.7) Description and Page Index
  Description: Homo sapiens protein arginine methyltransferase 9 (PRMT9), transcript variant 1, mRNA. (from RefSeq NM_138364)
RefSeq Summary (NM_138364): This gene encodes a type II methyltransferase. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to the guanidino nitrogen atoms of arginine. The protein encoded by this gene methylates spliceosome associated protein 145 to regulate alternative splicing and acts as a modulator of small nuclear ribonucleoprotein maturation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2017].
Gencode Transcript: ENST00000322396.7
Gencode Gene: ENSG00000164169.13
Transcript (Including UTRs)
   Position: hg38 chr4:147,637,785-147,684,163 Size: 46,379 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg38 chr4:147,638,532-147,683,987 Size: 45,456 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr4:147,637,785-147,684,163)mRNA (may differ from genome)Protein (845 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHPRD
LynxMGIneXtProtOMIMPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Putative protein arginine N-methyltransferase 10; EC=2.1.1.-;
SIMILARITY: Belongs to the protein arginine N-methyltransferase family.
SIMILARITY: Contains 3 TPR repeats.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.96 RPKM in Testis
Total median expression: 194.03 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.80176-0.328 Picture PostScript Text
3' UTR -158.40747-0.212 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025799 - Arg_MeTrfase
IPR010456 - Ribosomal-L11_MeTrfase_PrmA
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR013105 - TPR_2
IPR019734 - TPR_repeat

Pfam Domains:
PF06325 - Ribosomal protein L11 methyltransferase (PrmA)
PF07719 - Tetratricopeptide repeat

ModBase Predicted Comparative 3D Structure on Q6P2P2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl WormBase 
Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity
GO:0016740 transferase activity
GO:0035243 protein-arginine omega-N symmetric methyltransferase activity

Biological Process:
GO:0006397 mRNA processing
GO:0006479 protein methylation
GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine
GO:0032259 methylation
GO:0035246 peptidyl-arginine N-methylation

Cellular Component:
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  BC004337 - Homo sapiens hypothetical protein BC004337, mRNA (cDNA clone IMAGE:3631943), partial cds.
AL137452 - Homo sapiens mRNA; cDNA DKFZp761C029 (from clone DKFZp761C029).
AK292904 - Homo sapiens cDNA FLJ75167 complete cds.
BC021250 - Homo sapiens hypothetical protein BC004337, mRNA (cDNA clone IMAGE:3347567), partial cds.
BC064403 - Homo sapiens hypothetical protein BC004337, mRNA (cDNA clone MGC:75212 IMAGE:5547611), complete cds.
LF384403 - JP 2014500723-A/191906: Polycomb-Associated Non-Coding RNAs.
MA619980 - JP 2018138019-A/191906: Polycomb-Associated Non-Coding RNAs.
AK128483 - Homo sapiens cDNA FLJ46629 fis, clone TRACH2013585.
AK096703 - Homo sapiens cDNA FLJ39384 fis, clone PLACE5000066.
KJ895138 - Synthetic construct Homo sapiens clone ccsbBroadEn_04532 PRMT10 gene, encodes complete protein.
LF373074 - JP 2014500723-A/180577: Polycomb-Associated Non-Coding RNAs.
MA608651 - JP 2018138019-A/180577: Polycomb-Associated Non-Coding RNAs.
JD287646 - Sequence 268670 from Patent EP1572962.
JD416478 - Sequence 397502 from Patent EP1572962.
JD112966 - Sequence 93990 from Patent EP1572962.
JD114651 - Sequence 95675 from Patent EP1572962.
JD168868 - Sequence 149892 from Patent EP1572962.
LF373071 - JP 2014500723-A/180574: Polycomb-Associated Non-Coding RNAs.
MA608648 - JP 2018138019-A/180574: Polycomb-Associated Non-Coding RNAs.
LF373068 - JP 2014500723-A/180571: Polycomb-Associated Non-Coding RNAs.
MA608645 - JP 2018138019-A/180571: Polycomb-Associated Non-Coding RNAs.
JD235407 - Sequence 216431 from Patent EP1572962.
JD275070 - Sequence 256094 from Patent EP1572962.
JD195074 - Sequence 176098 from Patent EP1572962.
JD511149 - Sequence 492173 from Patent EP1572962.
JD535253 - Sequence 516277 from Patent EP1572962.
JD248067 - Sequence 229091 from Patent EP1572962.
LF373062 - JP 2014500723-A/180565: Polycomb-Associated Non-Coding RNAs.
MA608639 - JP 2018138019-A/180565: Polycomb-Associated Non-Coding RNAs.
JD278317 - Sequence 259341 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8KA39, ANM10_HUMAN, NM_138364, PRMT10, Q6P2P2, Q6ZR58, Q8N383, Q9BT55, Q9NT98, uc003ilc.1, uc003ilc.2, uc003ilc.3, uc003ilc.4, uc003ilc.5
UCSC ID: uc003ilc.5
RefSeq Accession: NM_138364
Protein: Q6P2P2 (aka ANM10_HUMAN)
CCDS: CCDS3771.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.