Human Gene PRMT9 (ENST00000322396.7) Description and Page Index
  Description: Homo sapiens protein arginine methyltransferase 9 (PRMT9), transcript variant 1, mRNA. (from RefSeq NM_138364)
RefSeq Summary (NM_138364): This gene encodes a type II methyltransferase. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to the guanidino nitrogen atoms of arginine. The protein encoded by this gene methylates spliceosome associated protein 145 to regulate alternative splicing and acts as a modulator of small nuclear ribonucleoprotein maturation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2017].
Gencode Transcript: ENST00000322396.7
Gencode Gene: ENSG00000164169.13
Transcript (Including UTRs)
   Position: hg38 chr4:147,637,785-147,684,163 Size: 46,379 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg38 chr4:147,638,532-147,683,987 Size: 45,456 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:147,637,785-147,684,163)mRNA (may differ from genome)Protein (845 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHPRD
LynxMGIneXtProtOMIMPubMedStanford SOURCE
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: ANM10_HUMAN
DESCRIPTION: RecName: Full=Putative protein arginine N-methyltransferase 10; EC=2.1.1.-;
SIMILARITY: Belongs to the protein arginine N-methyltransferase family.
SIMILARITY: Contains 3 TPR repeats.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.96 RPKM in Testis
Total median expression: 194.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.80176-0.328 Picture PostScript Text
3' UTR -158.40747-0.212 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025799 - Arg_MeTrfase
IPR010456 - Ribosomal-L11_MeTrfase_PrmA
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR013105 - TPR_2
IPR019734 - TPR_repeat

Pfam Domains:
PF06325 - Ribosomal protein L11 methyltransferase (PrmA)
PF07719 - Tetratricopeptide repeat

ModBase Predicted Comparative 3D Structure on Q6P2P2
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl WormBase 
Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity
GO:0016740 transferase activity
GO:0035243 protein-arginine omega-N symmetric methyltransferase activity

Biological Process:
GO:0006397 mRNA processing
GO:0006479 protein methylation
GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine
GO:0032259 methylation
GO:0035246 peptidyl-arginine N-methylation

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC004337 - Homo sapiens hypothetical protein BC004337, mRNA (cDNA clone IMAGE:3631943), partial cds.
AL137452 - Homo sapiens mRNA; cDNA DKFZp761C029 (from clone DKFZp761C029).
AK292904 - Homo sapiens cDNA FLJ75167 complete cds.
BC021250 - Homo sapiens hypothetical protein BC004337, mRNA (cDNA clone IMAGE:3347567), partial cds.
BC064403 - Homo sapiens hypothetical protein BC004337, mRNA (cDNA clone MGC:75212 IMAGE:5547611), complete cds.
LF384403 - JP 2014500723-A/191906: Polycomb-Associated Non-Coding RNAs.
MA619980 - JP 2018138019-A/191906: Polycomb-Associated Non-Coding RNAs.
AK128483 - Homo sapiens cDNA FLJ46629 fis, clone TRACH2013585.
AK096703 - Homo sapiens cDNA FLJ39384 fis, clone PLACE5000066.
KJ895138 - Synthetic construct Homo sapiens clone ccsbBroadEn_04532 PRMT10 gene, encodes complete protein.
LF373074 - JP 2014500723-A/180577: Polycomb-Associated Non-Coding RNAs.
MA608651 - JP 2018138019-A/180577: Polycomb-Associated Non-Coding RNAs.
JD287646 - Sequence 268670 from Patent EP1572962.
JD416478 - Sequence 397502 from Patent EP1572962.
JD112966 - Sequence 93990 from Patent EP1572962.
JD114651 - Sequence 95675 from Patent EP1572962.
JD168868 - Sequence 149892 from Patent EP1572962.
LF373071 - JP 2014500723-A/180574: Polycomb-Associated Non-Coding RNAs.
MA608648 - JP 2018138019-A/180574: Polycomb-Associated Non-Coding RNAs.
LF373068 - JP 2014500723-A/180571: Polycomb-Associated Non-Coding RNAs.
MA608645 - JP 2018138019-A/180571: Polycomb-Associated Non-Coding RNAs.
JD235407 - Sequence 216431 from Patent EP1572962.
JD275070 - Sequence 256094 from Patent EP1572962.
JD195074 - Sequence 176098 from Patent EP1572962.
JD511149 - Sequence 492173 from Patent EP1572962.
JD535253 - Sequence 516277 from Patent EP1572962.
JD248067 - Sequence 229091 from Patent EP1572962.
LF373062 - JP 2014500723-A/180565: Polycomb-Associated Non-Coding RNAs.
MA608639 - JP 2018138019-A/180565: Polycomb-Associated Non-Coding RNAs.
JD278317 - Sequence 259341 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8KA39, ANM10_HUMAN, NM_138364, PRMT10, Q6P2P2, Q6ZR58, Q8N383, Q9BT55, Q9NT98, uc003ilc.1, uc003ilc.2, uc003ilc.3, uc003ilc.4, uc003ilc.5
UCSC ID: uc003ilc.5
RefSeq Accession: NM_138364
Protein: Q6P2P2 (aka ANM10_HUMAN)
CCDS: CCDS3771.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.