Human Gene IL15 (ENST00000320650.9) Description and Page Index
Description: Homo sapiens interleukin 15 (IL15), transcript variant 3, mRNA. (from RefSeq NM_000585) RefSeq Summary (NM_000585): The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]. Gencode Transcript: ENST00000320650.9 Gencode Gene: ENSG00000164136.17 Transcript (Including UTRs) Position: hg38 chr4:141,636,583-141,733,987 Size: 97,405 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr4:141,719,465-141,732,848 Size: 13,384 Coding Exon Count: 6
ID:IL15_HUMAN DESCRIPTION: RecName: Full=Interleukin-15; Short=IL-15; Flags: Precursor; FUNCTION: Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. INTERACTION: Q13261:IL15RA; NbExp=3; IntAct=EBI-980274, EBI-980354; SUBCELLULAR LOCATION: Isoform IL15-S48AA: Secreted. SUBCELLULAR LOCATION: Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components. TISSUE SPECIFICITY: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus. SIMILARITY: Belongs to the IL-15/IL-21 family. SEQUENCE CAUTION: Sequence=CAA71044.1; Type=Miscellaneous discrepancy; Note=Man-made cDNA construct with a sequence coding for signal peptide increasing the secretion of the protein (substitution with a signal peptide derived from the mouse IgV kappa chain); WEB RESOURCE: Name=R&D Systems' cytokine source book: IL-15; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1671"; WEB RESOURCE: Name=Wikipedia; Note=Interleukin-15 entry; URL="http://en.wikipedia.org/wiki/Interleukin_15";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P40933
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.