Human Gene ZNF227 (ENST00000313040.12) Description and Page Index
  Description: Homo sapiens zinc finger protein 227 (ZNF227), transcript variant 2, mRNA. (from RefSeq NM_182490)
Gencode Transcript: ENST00000313040.12
Gencode Gene: ENSG00000131115.16
Transcript (Including UTRs)
   Position: hg38 chr19:44,212,532-44,237,268 Size: 24,737 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr19:44,217,793-44,236,830 Size: 19,038 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:44,212,532-44,237,268)mRNA (may differ from genome)Protein (799 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGImyGene2neXtProtPubMed
ReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZN227_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 227;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 19 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.90 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 59.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.80211-0.302 Picture PostScript Text
3' UTR -98.70438-0.225 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF01352 - KRAB box

ModBase Predicted Comparative 3D Structure on Q86WZ6
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK092253 - Homo sapiens cDNA FLJ34934 fis, clone NT2RP7005750, highly similar to Zinc finger protein 227.
AX747434 - Sequence 959 from Patent EP1308459.
AK316048 - Homo sapiens cDNA, FLJ78947 complete cds, highly similar to Zinc finger protein 227.
BC047570 - Homo sapiens zinc finger protein 227, mRNA (cDNA clone MGC:48349 IMAGE:4838846), complete cds.
AX721152 - Sequence 112 from Patent WO0220754.
AK311670 - Homo sapiens cDNA, FLJ18712.
AK300576 - Homo sapiens cDNA FLJ50866 complete cds, highly similar to Zinc finger protein 227.
AK299266 - Homo sapiens cDNA FLJ60337 complete cds, highly similar to Zinc finger protein 227.
CU690434 - Synthetic construct Homo sapiens gateway clone IMAGE:100020973 5' read ZNF227 mRNA.
JF432425 - Synthetic construct Homo sapiens clone IMAGE:100073632 zinc finger protein 227 (ZNF227) gene, encodes complete protein.
KJ892428 - Synthetic construct Homo sapiens clone ccsbBroadEn_01822 ZNF227 gene, encodes complete protein.
AL833012 - Homo sapiens mRNA; cDNA DKFZp666M044 (from clone DKFZp666M044).
AY166786 - Homo sapiens zinc finger protein ZNF227 (ZNF227) mRNA, partial cds.
AY500355 - Homo sapiens zinc finger protein 14 (HZF14) mRNA, partial cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86WZ6 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B3KRU7, NM_182490, Q86WZ6, uc002oyu.1, uc002oyu.2, uc002oyu.3, uc002oyu.4, uc002oyu.5, uc002oyu.6, ZN227_HUMAN
UCSC ID: uc002oyu.6
RefSeq Accession: NM_182490
Protein: Q86WZ6 (aka ZN227_HUMAN)
CCDS: CCDS12636.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.