Human Gene ZNF227 (ENST00000313040.12) Description and Page Index
  Description: Homo sapiens zinc finger protein 227 (ZNF227), transcript variant 2, mRNA. (from RefSeq NM_182490)
Gencode Transcript: ENST00000313040.12
Gencode Gene: ENSG00000131115.16
Transcript (Including UTRs)
   Position: hg38 chr19:44,212,532-44,237,268 Size: 24,737 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr19:44,217,793-44,236,830 Size: 19,038 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:44,212,532-44,237,268)mRNA (may differ from genome)Protein (799 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
ReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 227;
FUNCTION: May be involved in transcriptional regulation.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 19 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.90 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 59.96 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.80211-0.302 Picture PostScript Text
3' UTR -98.70438-0.225 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF01352 - KRAB box

ModBase Predicted Comparative 3D Structure on Q86WZ6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein Sequence     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AK092253 - Homo sapiens cDNA FLJ34934 fis, clone NT2RP7005750, highly similar to Zinc finger protein 227.
AX747434 - Sequence 959 from Patent EP1308459.
AK316048 - Homo sapiens cDNA, FLJ78947 complete cds, highly similar to Zinc finger protein 227.
BC047570 - Homo sapiens zinc finger protein 227, mRNA (cDNA clone MGC:48349 IMAGE:4838846), complete cds.
AX721152 - Sequence 112 from Patent WO0220754.
AK311670 - Homo sapiens cDNA, FLJ18712.
AK300576 - Homo sapiens cDNA FLJ50866 complete cds, highly similar to Zinc finger protein 227.
AK299266 - Homo sapiens cDNA FLJ60337 complete cds, highly similar to Zinc finger protein 227.
CU690434 - Synthetic construct Homo sapiens gateway clone IMAGE:100020973 5' read ZNF227 mRNA.
JF432425 - Synthetic construct Homo sapiens clone IMAGE:100073632 zinc finger protein 227 (ZNF227) gene, encodes complete protein.
KJ892428 - Synthetic construct Homo sapiens clone ccsbBroadEn_01822 ZNF227 gene, encodes complete protein.
AL833012 - Homo sapiens mRNA; cDNA DKFZp666M044 (from clone DKFZp666M044).
AY166786 - Homo sapiens zinc finger protein ZNF227 (ZNF227) mRNA, partial cds.
AY500355 - Homo sapiens zinc finger protein 14 (HZF14) mRNA, partial cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86WZ6 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B3KRU7, NM_182490, Q86WZ6, uc002oyu.1, uc002oyu.2, uc002oyu.3, uc002oyu.4, uc002oyu.5, uc002oyu.6, ZN227_HUMAN
UCSC ID: uc002oyu.6
RefSeq Accession: NM_182490
Protein: Q86WZ6 (aka ZN227_HUMAN)
CCDS: CCDS12636.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.