Human Gene PIGF (ENST00000306465.8) from GENCODE V41
Description: Homo sapiens phosphatidylinositol glycan anchor biosynthesis class F (PIGF), transcript variant 2, mRNA. (from RefSeq NM_173074) RefSeq Summary (NM_173074): This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000306465.8 Gencode Gene: ENSG00000151665.13 Transcript (Including UTRs) Position: hg38 chr2:46,581,285-46,617,051 Size: 35,767 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chr2:46,588,105-46,615,164 Size: 27,060 Coding Exon Count: 5
ID:PIGF_HUMAN DESCRIPTION: RecName: Full=Phosphatidylinositol-glycan biosynthesis class F protein; Short=PIG-F; AltName: Full=GPI11 homolog; FUNCTION: Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI (By similarity). PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis. SUBUNIT: Forms a complex with PIGG and PIGO. PIGF is required to stabilize PIGG and PIGO. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the PIGF family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06699 - GPI biosynthesis protein family Pig-F
ModBase Predicted Comparative 3D Structure on Q07326
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.