Human Gene MUC17 (ENST00000306151.9) Description and Page Index
Description: Homo sapiens mucin 17, cell surface associated (MUC17), transcript variant 1, mRNA. (from RefSeq NM_001040105) RefSeq Summary (NM_001040105): The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]. Gencode Transcript: ENST00000306151.9 Gencode Gene: ENSG00000169876.14 Transcript (Including UTRs) Position: hg38 chr7:101,020,081-101,058,859 Size: 38,779 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr7:101,020,136-101,058,044 Size: 37,909 Coding Exon Count: 13
ID:MUC17_HUMAN DESCRIPTION: RecName: Full=Mucin-17; Short=MUC-17; AltName: Full=Small intestinal mucin-3; Short=MUC-3; Flags: Precursor; FUNCTION: Probably plays a role in maintaining homeostasis on mucosal surfaces. SUBUNIT: Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass membrane protein. SUBCELLULAR LOCATION: Isoform 2: Secreted (Probable). Cell membrane. TISSUE SPECIFICITY: Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers. PTM: Probably cleaved within the SEA domain. PTM: N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated. SIMILARITY: Contains 1 EGF-like domain. SIMILARITY: Contains 1 SEA domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/MUC17ID41456ch7q22.html"; WEB RESOURCE: Name=Mucin database; URL="http://www.medkem.gu.se/mucinbiology/databases/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q685J3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
R-HSA-913675 GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens R-HSA-914012 GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins R-HSA-977228 Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position R-HSA-981497 ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position R-HSA-981814 GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position R-HSA-1964505 C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) R-HSA-914018 Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein R-HSA-914010 Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein R-HSA-5694487 A4GNT transfers GlcNAc to core 2 mucins R-HSA-6786012 CHST4 transfers SO4(2-) from PAPS to Core 2 mucins R-HSA-1964501 Addition of galactose to Core 6 glycoprotein R-HSA-977071 Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position R-HSA-981809 ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen R-HSA-8858500 CLEC10A binds Tn-MUC1 R-HSA-913709 O-linked glycosylation of mucins R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1) R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) R-HSA-977068 Termination of O-glycan biosynthesis R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) R-HSA-5621480 Dectin-2 family R-HSA-5173105 O-linked glycosylation R-HSA-3906995 Diseases associated with O-glycosylation of proteins R-HSA-5621481 C-type lectin receptors (CLRs) R-HSA-597592 Post-translational protein modification R-HSA-3781865 Diseases of glycosylation R-HSA-168249 Innate Immune System R-HSA-392499 Metabolism of proteins R-HSA-1643685 Disease R-HSA-168256 Immune System