Human Gene PTPRE (ENST00000306042.9) Description and Page Index
  Description: Homo sapiens protein tyrosine phosphatase receptor type E (PTPRE), transcript variant 2, mRNA. (from RefSeq NM_130435)
RefSeq Summary (NM_130435): The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015].
Gencode Transcript: ENST00000306042.9
Gencode Gene: ENSG00000132334.16
Transcript (Including UTRs)
   Position: hg38 chr10:128,047,570-128,085,855 Size: 38,286 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg38 chr10:128,047,649-128,082,906 Size: 35,258 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:128,047,570-128,085,855)mRNA (may differ from genome)Protein (642 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Receptor-type tyrosine-protein phosphatase epsilon; Short=Protein-tyrosine phosphatase epsilon; Short=R-PTP-epsilon; EC=; Flags: Precursor;
FUNCTION: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).
FUNCTION: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin- induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity).
FUNCTION: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+) (By similarity).
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
SUBUNIT: Monomer. Isoform 2: Homodimer. Can form oligomers. Dimerization is increased by oxidative stress and decreased by EGFR. Isoform 2 interacts with GRB2 (By similarity).
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane (By similarity).
SUBCELLULAR LOCATION: Isoform 3: Cytoplasm.
TISSUE SPECIFICITY: Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells).
INDUCTION: Up-regulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) in HL-60 cells.
DOMAIN: The tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the D2 domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme activity (By similarity).
PTM: A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3.
PTM: Isoform 1 and isoform 2 are phosphorylated on tyrosine residues by tyrosine kinase Neu.
PTM: Isoform 1 is glycosylated.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
SIMILARITY: Contains 2 tyrosine-protein phosphatase domains.
SEQUENCE CAUTION: Sequence=AAC50324.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.55 RPKM in Whole Blood
Total median expression: 188.07 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.3079-0.472 Picture PostScript Text
3' UTR -750.602949-0.255 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000387 - Tyr/Dual-specificity_Pase
IPR016130 - Tyr_Pase_AS
IPR000242 - Tyr_Pase_rcpt/non-rcpt
IPR016336 - Tyr_Pase_rcpt_a/e-type

Pfam Domains:
PF00102 - Protein-tyrosine phosphatase

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P23469
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity

Biological Process:
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0046627 negative regulation of insulin receptor signaling pathway

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC031078 - Homo sapiens cDNA clone IMAGE:5295028, containing frame-shift errors.
AF406557 - Homo sapiens PTPRE (PTPRE) mRNA, partial cds.
BC050062 - Homo sapiens protein tyrosine phosphatase, receptor type, E, mRNA (cDNA clone MGC:48280 IMAGE:5274802), complete cds.
X54134 - Human HPTP epsilon mRNA for protein tyrosine phosphatase epsilon.
AK291828 - Homo sapiens cDNA FLJ76898 complete cds, highly similar to Homo sapiens protein tyrosine phosphatase, receptor type, E (PTPRE), transcript variant 1, mRNA.
AK300613 - Homo sapiens cDNA FLJ58245 complete cds, highly similar to Receptor-type tyrosine-protein phosphatase epsilon precursor (EC
AK299498 - Homo sapiens cDNA FLJ57799 complete cds, highly similar to Receptor-type tyrosine-protein phosphatase epsilon precursor (EC
AB590774 - Synthetic construct DNA, clone: pFN21AB9968, Homo sapiens PTPRE gene for protein tyrosine phosphatase, receptor type, E, without stop codon, in Flexi system.
CU690634 - Synthetic construct Homo sapiens gateway clone IMAGE:100021005 5' read PTPRE mRNA.
JF432831 - Synthetic construct Homo sapiens clone IMAGE:100074150 protein tyrosine phosphatase, receptor type, E (PTPRE) gene, encodes complete protein.
KJ897423 - Synthetic construct Homo sapiens clone ccsbBroadEn_06817 PTPRE gene, encodes complete protein.
BX648180 - Homo sapiens mRNA; cDNA DKFZp686K099 (from clone DKFZp686K099).
BC071573 - Homo sapiens cDNA clone IMAGE:5269075, containing frame-shift errors.
AK290414 - Homo sapiens cDNA FLJ75634 complete cds, highly similar to Homo sapiens protein tyrosine phosphatase, receptor type, E (PTPRE), transcript variant 2, mRNA.
AJ430580 - Homo sapiens mRNA for tyrosine phosphatase epsilon PD1 (PTPRE gene).
AJ315969 - Homo sapiens mRNA for tyrosine phosphatase epsilon (PTPRE gene), cytoplasmic splice variant.
AK056111 - Homo sapiens cDNA FLJ31549 fis, clone NT2RI2001030, highly similar to PROTEIN-TYROSINE PHOSPHATASE EPSILON PRECURSOR (EC
JD278199 - Sequence 259223 from Patent EP1572962.
JD477469 - Sequence 458493 from Patent EP1572962.
U36623 - Homo sapiens protein tyrosine phosphatase epsilon cytoplasmic isoform (PTPRE) mRNA, partial cds.
JD097245 - Sequence 78269 from Patent EP1572962.
JD462726 - Sequence 443750 from Patent EP1572962.
AL832042 - Homo sapiens mRNA; cDNA DKFZp313F1310 (from clone DKFZp313F1310).
AK001335 - Homo sapiens cDNA FLJ10473 fis, clone NT2RP2000056, weakly similar to PROTEIN-TYROSINE PHOSPHATASE EPSILON PRECURSOR (EC
JD428864 - Sequence 409888 from Patent EP1572962.
AK026334 - Homo sapiens cDNA: FLJ22681 fis, clone HSI10693.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_130435, P23469, PTPRE_HUMAN, Q13345, Q5VWH3, Q5VWH4, Q96KQ6, uc001lkd.1, uc001lkd.2, uc001lkd.3, uc001lkd.4
UCSC ID: uc001lkd.4
RefSeq Accession: NM_130435
Protein: P23469 (aka PTPRE_HUMAN)
CCDS: CCDS7658.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.