Human Gene RBMY1F (ENST00000303766.11) Description and Page Index
Description: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. (from UniProt Q15415) RefSeq Summary (NM_152585): This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000303766.11 Gencode Gene: ENSG00000169800.13 Transcript (Including UTRs) Position: hg38 chrY:22,168,542-22,182,948 Size: 14,407 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chrY:22,168,820-22,180,969 Size: 12,150 Coding Exon Count: 11
ID:RBY1F_HUMAN DESCRIPTION: RecName: Full=RNA-binding motif protein, Y chromosome, family 1 member F/J; AltName: Full=Y chromosome RNA recognition motif 2; FUNCTION: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. SUBUNIT: Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Testis-specific. DEVELOPMENTAL STAGE: Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids. MISCELLANEOUS: The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08081 - RBM1CTR (NUC064) family PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
ModBase Predicted Comparative 3D Structure on Q15415
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.