Human Gene PDIA3 (ENST00000300289.10) Description and Page Index
  Description: Homo sapiens protein disulfide isomerase family A member 3 (PDIA3), mRNA. (from RefSeq NM_005313)
RefSeq Summary (NM_005313): This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.215983.1, SRR1660803.78112.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000300289.10/ ENSP00000300289.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000300289.10
Gencode Gene: ENSG00000167004.13
Transcript (Including UTRs)
   Position: hg38 chr15:43,746,438-43,773,278 Size: 26,841 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr15:43,746,540-43,771,218 Size: 24,679 Coding Exon Count: 13 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr15:43,746,438-43,773,278)mRNA (may differ from genome)Protein (505 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  MalaCards Disease Associations
  MalaCards Gene Search: PDIA3
Diseases sorted by gene-association score: maxillary sinus squamous cell carcinoma (16), anomalous left coronary artery from the pulmonary artery (9), maxillary sinus cancer (6), paranasal sinus cancer (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 205.29 RPKM in Thyroid
Total median expression: 3926.70 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.00102-0.314 Picture PostScript Text
3' UTR -575.602060-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Descriptions from all associated GenBank mRNAs
  LF383724 - JP 2014500723-A/191227: Polycomb-Associated Non-Coding RNAs.
MA619301 - JP 2018138019-A/191227: Polycomb-Associated Non-Coding RNAs.
LP895981 - Sequence 845 from Patent EP3253886.
AK075481 - Homo sapiens cDNA PSEC0175 fis, clone OVARC1000169, highly similar to Protein disulfide-isomerase A3 precursor (EC
AK293249 - Homo sapiens cDNA FLJ59460 complete cds, highly similar to Protein disulfide-isomerase A3 precursor (EC
BC036000 - Homo sapiens protein disulfide isomerase family A, member 3, mRNA (cDNA clone MGC:32821 IMAGE:4712175), complete cds.
EU668338 - Homo sapiens epididymis secretory protein Li 269 (HEL-S-269) mRNA, complete cds.
Z49835 - H.sapiens mRNA for protein disulfide isomerase.
BC071878 - Homo sapiens protein disulfide isomerase family A, member 3, mRNA (cDNA clone MGC:88551 IMAGE:6380973), complete cds.
FJ224330 - Homo sapiens epididymis secretory sperm binding protein Li 93n (HEL-S-93n) mRNA, complete cds.
BC014433 - Homo sapiens protein disulfide isomerase family A, member 3, mRNA (cDNA clone MGC:2159 IMAGE:3542405), complete cds.
AK075455 - Homo sapiens cDNA PSEC0148 fis, clone PLACE1007202, highly similar to Protein disulfide-isomerase A3 precursor (EC
U42068 - Human liver endoplasmic reticulum P58 mRNA, complete cds.
D16234 - Homo sapiens mRNA for phospholipase C-alpha, complete cds.
D83485 - Homo sapiens mRNA for ER-60 protease, complete cds.
AB527303 - Synthetic construct DNA, clone: pF1KB5019, Homo sapiens PDIA3 gene for protein disulfide isomerase family A, member 3, without stop codon, in Flexi system.
CU690254 - Synthetic construct Homo sapiens gateway clone IMAGE:100022268 5' read PDIA3 mRNA.
KJ896934 - Synthetic construct Homo sapiens clone ccsbBroadEn_06328 PDIA3 gene, encodes complete protein.
DQ896325 - Synthetic construct Homo sapiens clone IMAGE:100010785; FLH193290.01L; RZPDo839E0968D protein disulfide isomerase family A, member 3 (PDIA3) gene, encodes complete protein.
DQ893070 - Synthetic construct clone IMAGE:100005700; FLH193294.01X; RZPDo839E0978D protein disulfide isomerase family A, member 3 (PDIA3) gene, encodes complete protein.
KJ891305 - Synthetic construct Homo sapiens clone ccsbBroadEn_00699 PDIA3 gene, encodes complete protein.
DQ577096 - Homo sapiens piRNA piR-45208, complete sequence.
LF349006 - JP 2014500723-A/156509: Polycomb-Associated Non-Coding RNAs.
MA584583 - JP 2018138019-A/156509: Polycomb-Associated Non-Coding RNAs.
LF349008 - JP 2014500723-A/156511: Polycomb-Associated Non-Coding RNAs.
MA584585 - JP 2018138019-A/156511: Polycomb-Associated Non-Coding RNAs.
LF349010 - JP 2014500723-A/156513: Polycomb-Associated Non-Coding RNAs.
MA584587 - JP 2018138019-A/156513: Polycomb-Associated Non-Coding RNAs.
LF349011 - JP 2014500723-A/156514: Polycomb-Associated Non-Coding RNAs.
MA584588 - JP 2018138019-A/156514: Polycomb-Associated Non-Coding RNAs.
LF349012 - JP 2014500723-A/156515: Polycomb-Associated Non-Coding RNAs.
MA584589 - JP 2018138019-A/156515: Polycomb-Associated Non-Coding RNAs.
LF349013 - JP 2014500723-A/156516: Polycomb-Associated Non-Coding RNAs.
MA584590 - JP 2018138019-A/156516: Polycomb-Associated Non-Coding RNAs.
LF349014 - JP 2014500723-A/156517: Polycomb-Associated Non-Coding RNAs.
MA584591 - JP 2018138019-A/156517: Polycomb-Associated Non-Coding RNAs.
LF349016 - JP 2014500723-A/156519: Polycomb-Associated Non-Coding RNAs.
MA584593 - JP 2018138019-A/156519: Polycomb-Associated Non-Coding RNAs.
LF349017 - JP 2014500723-A/156520: Polycomb-Associated Non-Coding RNAs.
MA584594 - JP 2018138019-A/156520: Polycomb-Associated Non-Coding RNAs.
LF349019 - JP 2014500723-A/156522: Polycomb-Associated Non-Coding RNAs.
MA584596 - JP 2018138019-A/156522: Polycomb-Associated Non-Coding RNAs.
LF349021 - JP 2014500723-A/156524: Polycomb-Associated Non-Coding RNAs.
MA584598 - JP 2018138019-A/156524: Polycomb-Associated Non-Coding RNAs.
LF349022 - JP 2014500723-A/156525: Polycomb-Associated Non-Coding RNAs.
MA584599 - JP 2018138019-A/156525: Polycomb-Associated Non-Coding RNAs.
LF349023 - JP 2014500723-A/156526: Polycomb-Associated Non-Coding RNAs.
MA584600 - JP 2018138019-A/156526: Polycomb-Associated Non-Coding RNAs.
LF349024 - JP 2014500723-A/156527: Polycomb-Associated Non-Coding RNAs.
MA584601 - JP 2018138019-A/156527: Polycomb-Associated Non-Coding RNAs.
JD062156 - Sequence 43180 from Patent EP1572962.
LF349025 - JP 2014500723-A/156528: Polycomb-Associated Non-Coding RNAs.
MA584602 - JP 2018138019-A/156528: Polycomb-Associated Non-Coding RNAs.
LF349026 - JP 2014500723-A/156529: Polycomb-Associated Non-Coding RNAs.
MA584603 - JP 2018138019-A/156529: Polycomb-Associated Non-Coding RNAs.
JD502537 - Sequence 483561 from Patent EP1572962.
JD550854 - Sequence 531878 from Patent EP1572962.
JD359147 - Sequence 340171 from Patent EP1572962.
LF349027 - JP 2014500723-A/156530: Polycomb-Associated Non-Coding RNAs.
MA584604 - JP 2018138019-A/156530: Polycomb-Associated Non-Coding RNAs.
JD559845 - Sequence 540869 from Patent EP1572962.
LF205859 - JP 2014500723-A/13362: Polycomb-Associated Non-Coding RNAs.
MA441436 - JP 2018138019-A/13362: Polycomb-Associated Non-Coding RNAs.
CU675446 - Synthetic construct Homo sapiens gateway clone IMAGE:100021915 3' read ELL3 mRNA.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04612 - Antigen processing and presentation

-  Other Names for This Gene
  Alternate Gene Symbols: NM_005313, uc001zsu.1, uc001zsu.2, uc001zsu.3, uc001zsu.4, uc001zsu.5, V9HVY3
UCSC ID: uc001zsu.5
RefSeq Accession: NM_005313
CCDS: CCDS10101.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.