Human Gene TMEM184C (ENST00000296582.8) Description and Page Index
  Description: Homo sapiens transmembrane protein 184C (TMEM184C), mRNA. (from RefSeq NM_018241)
Gencode Transcript: ENST00000296582.8
Gencode Gene: ENSG00000164168.8
Transcript (Including UTRs)
   Position: hg38 chr4:147,617,397-147,636,721 Size: 19,325 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg38 chr4:147,617,957-147,634,434 Size: 16,478 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:147,617,397-147,636,721)mRNA (may differ from genome)Protein (438 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: T184C_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 184C; AltName: Full=Transmembrane protein 34;
FUNCTION: Possible tumor suppressor which may play a role in cell growth.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
TISSUE SPECIFICITY: Widely expressed with higher expression in lung, kidney, spleen, pancreas, thymus, prostate, testis, ovary, small intestine and thyroid.
SIMILARITY: Belongs to the TMEM184 family.
SEQUENCE CAUTION: Sequence=AAK55526.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA90988.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.49 RPKM in Thyroid
Total median expression: 314.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -210.40560-0.376 Picture PostScript Text
3' UTR -482.902287-0.211 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005178 - Ost-alpha

Pfam Domains:
PF03619 - Organic solute transporter Ostalpha

ModBase Predicted Comparative 3D Structure on Q9NVA4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
MGIRGDEnsemblEnsembl SGD
Protein SequenceProtein Sequence Protein Sequence Protein Sequence
AlignmentAlignment Alignment Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005215 transporter activity

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ902873 - Synthetic construct Homo sapiens clone ccsbBroadEn_12267 TMEM184C gene, encodes complete protein.
BC046128 - Homo sapiens transmembrane protein 184C, mRNA (cDNA clone MGC:57601 IMAGE:5750613), complete cds.
AK001708 - Homo sapiens cDNA FLJ10846 fis, clone NT2RP4001373.
JD205232 - Sequence 186256 from Patent EP1572962.
JD154920 - Sequence 135944 from Patent EP1572962.
JD460929 - Sequence 441953 from Patent EP1572962.
JD141815 - Sequence 122839 from Patent EP1572962.
JD145669 - Sequence 126693 from Patent EP1572962.
JD476370 - Sequence 457394 from Patent EP1572962.
JD151102 - Sequence 132126 from Patent EP1572962.
JD468762 - Sequence 449786 from Patent EP1572962.
JD089211 - Sequence 70235 from Patent EP1572962.
JD409454 - Sequence 390478 from Patent EP1572962.
JD227667 - Sequence 208691 from Patent EP1572962.
JD523141 - Sequence 504165 from Patent EP1572962.
JD433201 - Sequence 414225 from Patent EP1572962.
JD052778 - Sequence 33802 from Patent EP1572962.
CU692306 - Synthetic construct Homo sapiens gateway clone IMAGE:100021298 5' read TMEM34 mRNA.
AK000169 - Homo sapiens cDNA FLJ20162 fis, clone COL09280.
AF305823 - Homo sapiens PRO1355 mRNA, complete cds.
BC008120 - Homo sapiens transmembrane protein 184C, mRNA (cDNA clone IMAGE:3448856), partial cds.
JD396829 - Sequence 377853 from Patent EP1572962.
JD353193 - Sequence 334217 from Patent EP1572962.
JD353194 - Sequence 334218 from Patent EP1572962.
JD409133 - Sequence 390157 from Patent EP1572962.
JD219455 - Sequence 200479 from Patent EP1572962.
JD251946 - Sequence 232970 from Patent EP1572962.
JD515652 - Sequence 496676 from Patent EP1572962.
JD374861 - Sequence 355885 from Patent EP1572962.
JD441199 - Sequence 422223 from Patent EP1572962.
JD441198 - Sequence 422222 from Patent EP1572962.
JD064061 - Sequence 45085 from Patent EP1572962.
JD064062 - Sequence 45086 from Patent EP1572962.
JD064063 - Sequence 45087 from Patent EP1572962.
JD143861 - Sequence 124885 from Patent EP1572962.
JD143808 - Sequence 124832 from Patent EP1572962.
JD172189 - Sequence 153213 from Patent EP1572962.
JD084822 - Sequence 65846 from Patent EP1572962.
JD296523 - Sequence 277547 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DP04, NM_018241, PRO1355, Q86X84, Q969I7, Q9NVA4, Q9NXM2, T184C_HUMAN, TMEM34, uc003ila.1, uc003ila.2, uc003ila.3, uc003ila.4, uc003ila.5, uc003ila.6
UCSC ID: uc003ila.6
RefSeq Accession: NM_018241
Protein: Q9NVA4 (aka T184C_HUMAN)
CCDS: CCDS3770.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.