Human Gene TMEM144 (ENST00000296529.11) Description and Page Index
  Description: Homo sapiens transmembrane protein 144 (TMEM144), mRNA. (from RefSeq NM_018342)
Gencode Transcript: ENST00000296529.11
Gencode Gene: ENSG00000164124.11
Transcript (Including UTRs)
   Position: hg38 chr4:158,210,486-158,255,416 Size: 44,931 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr4:158,212,668-158,253,527 Size: 40,860 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr4:158,210,486-158,255,416)mRNA (may differ from genome)Protein (345 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transmembrane protein 144;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM144 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 43.44 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 180.91 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.30283-0.277 Picture PostScript Text
3' UTR -431.601889-0.228 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012435 - DUF1632_TMEM144

Pfam Domains:
PF07857 - Transmembrane family, TMEM144 of transporters

ModBase Predicted Comparative 3D Structure on Q7Z5S9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl WormBase 
Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0015144 carbohydrate transmembrane transporter activity

Biological Process:
GO:0034219 carbohydrate transmembrane transport

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  LP896320 - Sequence 1184 from Patent EP3253886.
LP895492 - Sequence 356 from Patent EP3253886.
BC036551 - Homo sapiens transmembrane protein 144, mRNA (cDNA clone IMAGE:5264816), complete cds.
BC048117 - Homo sapiens transmembrane protein 144, mRNA (cDNA clone IMAGE:5264713), complete cds.
BC054487 - Homo sapiens transmembrane protein 144, mRNA (cDNA clone MGC:51851 IMAGE:5732836), complete cds.
BC060875 - Homo sapiens transmembrane protein 144, mRNA (cDNA clone MGC:71832 IMAGE:4800219), complete cds.
BC035811 - Homo sapiens transmembrane protein 144, mRNA (cDNA clone IMAGE:5754243).
BC026318 - Homo sapiens transmembrane protein 144, mRNA (cDNA clone IMAGE:4799382).
AK002017 - Homo sapiens cDNA FLJ11155 fis, clone PLACE1006935.
JD322323 - Sequence 303347 from Patent EP1572962.
JD021648 - Sequence 2672 from Patent EP1572962.
JD028921 - Sequence 9945 from Patent EP1572962.
CU691090 - Synthetic construct Homo sapiens gateway clone IMAGE:100021385 5' read TMEM144 mRNA.
CU687490 - Synthetic construct Homo sapiens gateway clone IMAGE:100021114 5' read TMEM144 mRNA.
HQ448479 - Synthetic construct Homo sapiens clone IMAGE:100071911; CCSB010956_01 transmembrane protein 144 (TMEM144) gene, encodes complete protein.
KJ894183 - Synthetic construct Homo sapiens clone ccsbBroadEn_03577 TMEM144 gene, encodes complete protein.
KJ899119 - Synthetic construct Homo sapiens clone ccsbBroadEn_08513 TMEM144 gene, encodes complete protein.
BC050297 - Homo sapiens transmembrane protein 144, mRNA (cDNA clone IMAGE:5299592), with apparent retained intron.
JD370698 - Sequence 351722 from Patent EP1572962.
JD507892 - Sequence 488916 from Patent EP1572962.
JD374964 - Sequence 355988 from Patent EP1572962.
JD345923 - Sequence 326947 from Patent EP1572962.
JD404102 - Sequence 385126 from Patent EP1572962.
JD373783 - Sequence 354807 from Patent EP1572962.
JD497479 - Sequence 478503 from Patent EP1572962.
JD541902 - Sequence 522926 from Patent EP1572962.
JD452476 - Sequence 433500 from Patent EP1572962.
JD466572 - Sequence 447596 from Patent EP1572962.
JD544124 - Sequence 525148 from Patent EP1572962.
JD199015 - Sequence 180039 from Patent EP1572962.
JD061544 - Sequence 42568 from Patent EP1572962.
JD043986 - Sequence 25010 from Patent EP1572962.
JD066553 - Sequence 47577 from Patent EP1572962.
JD180939 - Sequence 161963 from Patent EP1572962.
JD305044 - Sequence 286068 from Patent EP1572962.
JD241726 - Sequence 222750 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DP24, NM_018342, Q49A05, Q7Z5S9, Q9NUT3, TM144_HUMAN, uc003ipx.1, uc003ipx.2, uc003ipx.3, uc003ipx.4, uc003ipx.5
UCSC ID: uc003ipx.5
RefSeq Accession: NM_018342
Protein: Q7Z5S9 (aka TM144_HUMAN)
CCDS: CCDS3799.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.