Human Gene SULT1C4 (ENST00000272452.7) Description and Page Index
  Description: Homo sapiens sulfotransferase family 1C member 4 (SULT1C4), transcript variant 1, mRNA. (from RefSeq NM_006588)
RefSeq Summary (NM_006588): Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments, including RNA-seq data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.264815.1, SRR1803616.413212.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000272452.7/ ENSP00000272452.2 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000272452.7
Gencode Gene: ENSG00000198075.10
Transcript (Including UTRs)
   Position: hg38 chr2:108,377,954-108,388,989 Size: 11,036 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr2:108,378,338-108,387,432 Size: 9,095 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:108,377,954-108,388,989)mRNA (may differ from genome)Protein (302 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCHPRD
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Sulfotransferase 1C4; Short=ST1C4; EC=2.8.2.-; AltName: Full=Sulfotransferase 1C2; Short=SULT1C#2;
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).
TISSUE SPECIFICITY: Expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord.
SIMILARITY: Belongs to the sulfotransferase 1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.88 RPKM in Ovary
Total median expression: 121.35 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -154.20384-0.402 Picture PostScript Text
3' UTR -359.801557-0.231 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000863 - Sulfotransferase_dom

Pfam Domains:
PF00685 - Sulfotransferase domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on O75897
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004062 aryl sulfotransferase activity
GO:0008146 sulfotransferase activity
GO:0016740 transferase activity

Biological Process:
GO:0006068 ethanol catabolic process
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923 sulfation

Cellular Component:
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  BC058861 - Homo sapiens sulfotransferase family, cytosolic, 1C, member 4, mRNA (cDNA clone IMAGE:5191408), complete cds.
AK298755 - Homo sapiens cDNA FLJ60793 complete cds, highly similar to Sulfotransferase 1C2 (EC 2.8.2.-).
JD096204 - Sequence 77228 from Patent EP1572962.
AF055584 - Homo sapiens SULT1C sulfotransferase (SULT1C) mRNA, complete cds.
JD275926 - Sequence 256950 from Patent EP1572962.
JD419673 - Sequence 400697 from Patent EP1572962.
JD548936 - Sequence 529960 from Patent EP1572962.
JD109917 - Sequence 90941 from Patent EP1572962.
AK297851 - Homo sapiens cDNA FLJ53816 complete cds, highly similar to Sulfotransferase 1C2 (EC 2.8.2.-).
JD096285 - Sequence 77309 from Patent EP1572962.
JD500324 - Sequence 481348 from Patent EP1572962.
JD095580 - Sequence 76604 from Patent EP1572962.
JD101755 - Sequence 82779 from Patent EP1572962.
BC125043 - Homo sapiens sulfotransferase family, cytosolic, 1C, member 4, mRNA (cDNA clone MGC:149521 IMAGE:40115974), complete cds.
JD222637 - Sequence 203661 from Patent EP1572962.
KJ902461 - Synthetic construct Homo sapiens clone ccsbBroadEn_11855 SULT1C4 gene, encodes complete protein.
KJ902462 - Synthetic construct Homo sapiens clone ccsbBroadEn_11856 SULT1C4 gene, encodes complete protein.
JD345941 - Sequence 326965 from Patent EP1572962.
JD562549 - Sequence 543573 from Patent EP1572962.
JD473304 - Sequence 454328 from Patent EP1572962.
JD546125 - Sequence 527149 from Patent EP1572962.
JD373782 - Sequence 354806 from Patent EP1572962.
JD540323 - Sequence 521347 from Patent EP1572962.
JD049968 - Sequence 30992 from Patent EP1572962.
JD059650 - Sequence 40674 from Patent EP1572962.
JD287357 - Sequence 268381 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O75897 (Reactome details) participates in the following event(s):

R-HSA-176646 p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP
R-HSA-176669 N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP
R-HSA-156584 Cytosolic sulfonation of small molecules
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-211859 Biological oxidations
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: NM_006588, O75897, Q069I8, Q53S63, ST1C4_HUMAN, SULT1C2, uc002tea.1, uc002tea.2, uc002tea.3
UCSC ID: uc002tea.3
RefSeq Accession: NM_006588
Protein: O75897 (aka ST1C4_HUMAN)
CCDS: CCDS2077.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.