Human Gene SULT1C4 (ENST00000272452.7) Description and Page Index
Description: Homo sapiens sulfotransferase family 1C member 4 (SULT1C4), transcript variant 1, mRNA. (from RefSeq NM_006588) RefSeq Summary (NM_006588): Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments, including RNA-seq data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.264815.1, SRR1803616.413212.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000272452.7/ ENSP00000272452.2 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## Gencode Transcript: ENST00000272452.7 Gencode Gene: ENSG00000198075.10 Transcript (Including UTRs) Position: hg38 chr2:108,377,954-108,388,989 Size: 11,036 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr2:108,378,338-108,387,432 Size: 9,095 Coding Exon Count: 7
ID:ST1C4_HUMAN DESCRIPTION: RecName: Full=Sulfotransferase 1C4; Short=ST1C4; EC=2.8.2.-; AltName: Full=Sulfotransferase 1C2; Short=SULT1C#2; FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord. SIMILARITY: Belongs to the sulfotransferase 1 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/sult1c2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75897
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.