Human Gene FNDC4 (ENST00000264703.4) Description and Page Index
  Description: Homo sapiens fibronectin type III domain containing 4 (FNDC4), mRNA. (from RefSeq NM_022823)
Gencode Transcript: ENST00000264703.4
Gencode Gene: ENSG00000115226.10
Transcript (Including UTRs)
   Position: hg38 chr2:27,491,883-27,495,200 Size: 3,318 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr2:27,492,443-27,494,679 Size: 2,237 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:27,491,883-27,495,200)mRNA (may differ from genome)Protein (234 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Fibronectin type III domain-containing protein 4; AltName: Full=Fibronectin type III repeat-containing protein 1; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
SIMILARITY: Contains 1 fibronectin type-III domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: FNDC4
Diseases sorted by gene-association score: fuchs' endothelial dystrophy (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 94.87 RPKM in Adrenal Gland
Total median expression: 837.86 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -189.40347-0.546 Picture PostScript Text
3' UTR -218.30560-0.390 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003961 - Fibronectin_type3
IPR013783 - Ig-like_fold

Pfam Domains:
PF00041 - Fibronectin type III domain

ModBase Predicted Comparative 3D Structure on Q9H6D8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0050728 negative regulation of inflammatory response
GO:0071559 response to transforming growth factor beta

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC032725 - Homo sapiens fibronectin type III domain containing 4, mRNA (cDNA clone MGC:44971 IMAGE:5533159), complete cds.
AK026015 - Homo sapiens cDNA: FLJ22362 fis, clone HRC06544.
BC024175 - Homo sapiens cDNA clone IMAGE:4820754, containing frame-shift errors.
JD247866 - Sequence 228890 from Patent EP1572962.
JD443619 - Sequence 424643 from Patent EP1572962.
JD119593 - Sequence 100617 from Patent EP1572962.
JD548557 - Sequence 529581 from Patent EP1572962.
JD354678 - Sequence 335702 from Patent EP1572962.
JD493772 - Sequence 474796 from Patent EP1572962.
AY358136 - Homo sapiens clone DNA167975 PSGC6389 (UNQ6389) mRNA, complete cds.
JD044203 - Sequence 25227 from Patent EP1572962.
JD235766 - Sequence 216790 from Patent EP1572962.
JD069107 - Sequence 50131 from Patent EP1572962.
JD346921 - Sequence 327945 from Patent EP1572962.
JD162185 - Sequence 143209 from Patent EP1572962.
JD477534 - Sequence 458558 from Patent EP1572962.
JD223998 - Sequence 205022 from Patent EP1572962.
JD077765 - Sequence 58789 from Patent EP1572962.
CU689508 - Synthetic construct Homo sapiens gateway clone IMAGE:100023235 5' read FNDC4 mRNA.
KJ894581 - Synthetic construct Homo sapiens clone ccsbBroadEn_03975 FNDC4 gene, encodes complete protein.
DQ894022 - Synthetic construct Homo sapiens clone IMAGE:100008482; FLH166621.01L; RZPDo839B0687D fibronectin type III domain containing 4 (FNDC4) gene, encodes complete protein.
EU176181 - Synthetic construct Homo sapiens clone IMAGE:100006350; FLH166628.01X; RZPDo839H03250D fibronectin type III domain containing 4 (FNDC4) gene, encodes complete protein.
JD109011 - Sequence 90035 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D6W560, FNDC4_HUMAN, FRCP1, NM_022823, Q9H6D8, uc002rkx.1, uc002rkx.2, uc002rkx.3, uc002rkx.4, uc002rkx.5, UNQ6389/PRO21134
UCSC ID: uc002rkx.5
RefSeq Accession: NM_022823
Protein: Q9H6D8 (aka FNDC4_HUMAN)
CCDS: CCDS1756.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.