Human Gene TSPAN13 (ENST00000262067.5) Description and Page Index
  Description: Homo sapiens tetraspanin 13 (TSPAN13), mRNA. (from RefSeq NM_014399)
RefSeq Summary (NM_014399): The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.295733.1, SRR1660809.40091.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262067.5/ ENSP00000262067.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000262067.5
Gencode Gene: ENSG00000106537.8
Transcript (Including UTRs)
   Position: hg38 chr7:16,753,755-16,784,536 Size: 30,782 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr7:16,753,968-16,783,491 Size: 29,524 Coding Exon Count: 6 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:16,753,755-16,784,536)mRNA (may differ from genome)Protein (204 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 83.45 RPKM in Pituitary
Total median expression: 947.92 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -90.00213-0.423 Picture PostScript Text
3' UTR -218.601045-0.209 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000301 - Tetraspanin
IPR018499 - Tetraspanin/Peripherin

Pfam Domains:
PF00335 - Tetraspanin family

ModBase Predicted Comparative 3D Structure on Q6FGK0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005246 calcium channel regulator activity

Biological Process:
GO:1903169 regulation of calcium ion transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK093487 - Homo sapiens cDNA FLJ36168 fis, clone TESTI2026134, highly similar to Homo sapiens tetraspan NET-6 mRNA.
AK026587 - Homo sapiens cDNA: FLJ22934 fis, clone KAT07572, highly similar to AF100759 Homo sapiens transmembrane 4 superfamily protein mRNA.
AK316595 - Homo sapiens cDNA, FLJ95977, Homo sapiens transmembrane 4 superfamily member 13 (TM4SF13), mRNA.
AK075475 - Homo sapiens cDNA PSEC0169 fis, clone PLACE1011360, highly similar to Tetraspanin-13.
AY358995 - Homo sapiens clone DNA39979 NET-6 (UNQ260) mRNA, complete cds.
AF100759 - Homo sapiens transmembrane 4 superfamily protein mRNA, complete cds.
BC033863 - Homo sapiens tetraspanin 13, mRNA (cDNA clone MGC:45139 IMAGE:5187772), complete cds.
AF120265 - Homo sapiens tetraspan NET-6 mRNA, complete cds.
DQ892059 - Synthetic construct clone IMAGE:100004689; FLH182776.01X; RZPDo839C02140D tetraspanin 13 (TSPAN13) gene, encodes complete protein.
DQ895252 - Synthetic construct Homo sapiens clone IMAGE:100009712; FLH182772.01L; RZPDo839C02139D tetraspanin 13 (TSPAN13) gene, encodes complete protein.
CR542107 - Homo sapiens full open reading frame cDNA clone RZPDo834F0637D for gene TM4SF13, transmembrane 4 superfamily member 13; complete cds, incl. stopcodon.
JD367583 - Sequence 348607 from Patent EP1572962.
JD535382 - Sequence 516406 from Patent EP1572962.
JD143599 - Sequence 124623 from Patent EP1572962.
JD559429 - Sequence 540453 from Patent EP1572962.
JD229584 - Sequence 210608 from Patent EP1572962.
BX647338 - Homo sapiens mRNA; cDNA DKFZp779I2416 (from clone DKFZp779I2416).
JD304719 - Sequence 285743 from Patent EP1572962.
JD250576 - Sequence 231600 from Patent EP1572962.
JD350213 - Sequence 331237 from Patent EP1572962.
JD313103 - Sequence 294127 from Patent EP1572962.
JD491411 - Sequence 472435 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: hCG_17375, NM_014399, Q6FGK0, Q6FGK0_HUMAN, tcag7.1203, TM4SF13, uc003stq.1, uc003stq.2, uc003stq.3, uc003stq.4, uc003stq.5
UCSC ID: uc003stq.5
RefSeq Accession: NM_014399
Protein: Q6FGK0 CCDS: CCDS5363.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.