Human Gene NDUFB5 (ENST00000259037.8) Description and Page Index
  Description: Homo sapiens NADH:ubiquinone oxidoreductase subunit B5 (NDUFB5), transcript variant 1, mRNA. (from RefSeq NM_002492)
RefSeq Summary (NM_002492): The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
Gencode Transcript: ENST00000259037.8
Gencode Gene: ENSG00000136521.13
Transcript (Including UTRs)
   Position: hg38 chr3:179,604,794-179,627,647 Size: 22,854 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr3:179,604,816-179,624,040 Size: 19,225 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:179,604,794-179,627,647)mRNA (may differ from genome)Protein (189 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: NDUB5_HUMAN
DESCRIPTION: RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial; AltName: Full=Complex I-SGDH; Short=CI-SGDH; AltName: Full=NADH-ubiquinone oxidoreductase SGDH subunit; Flags: Precursor;
FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
SUBUNIT: Complex I is composed of 45 different subunits.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
SIMILARITY: Belongs to the complex I NDUFB5 subunit family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 26.98 RPKM in Heart - Left Ventricle
Total median expression: 622.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.6022-0.073 Picture PostScript Text
3' UTR -919.303607-0.255 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019173 - NADH_UbQ_OxRdtase_B5_su

Pfam Domains:
PF09781 - NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit

ModBase Predicted Comparative 3D Structure on O43674
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008137 NADH dehydrogenase (ubiquinone) activity

Biological Process:
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070469 respiratory chain


-  Descriptions from all associated GenBank mRNAs
  BX648034 - Homo sapiens mRNA; cDNA DKFZp686N02262 (from clone DKFZp686N02262).
BC005271 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa, mRNA (cDNA clone MGC:12314 IMAGE:3997377), complete cds.
BC009796 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa, mRNA (cDNA clone MGC:13617 IMAGE:4284776), complete cds.
JD026494 - Sequence 7518 from Patent EP1572962.
AK313822 - Homo sapiens cDNA, FLJ94443, highly similar to Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa (NDUFB5), mRNA.
BC093071 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa, mRNA (cDNA clone MGC:111204 IMAGE:30325282), complete cds.
AF047181 - Homo sapiens NADH-ubiquinone oxidoreductase subunit CI-SGDH mRNA, complete cds.
JD024279 - Sequence 5303 from Patent EP1572962.
BC017909 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa, mRNA (cDNA clone IMAGE:4278928), complete cds.
JD034164 - Sequence 15188 from Patent EP1572962.
JD034163 - Sequence 15187 from Patent EP1572962.
HQ448677 - Synthetic construct Homo sapiens clone IMAGE:100072119; CCSB006438_01 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa (NDUFB5) gene, encodes complete protein.
KJ891677 - Synthetic construct Homo sapiens clone ccsbBroadEn_01071 NDUFB5 gene, encodes complete protein.
CU679497 - Synthetic construct Homo sapiens gateway clone IMAGE:100018003 5' read NDUFB5 mRNA.
JD306192 - Sequence 287216 from Patent EP1572962.
JD501825 - Sequence 482849 from Patent EP1572962.
JD036481 - Sequence 17505 from Patent EP1572962.
JD357366 - Sequence 338390 from Patent EP1572962.
JD445888 - Sequence 426912 from Patent EP1572962.
JD484330 - Sequence 465354 from Patent EP1572962.
AK055159 - Homo sapiens cDNA FLJ30597 fis, clone BRAWH2009261, weakly similar to TLM PROTEIN.
JD521005 - Sequence 502029 from Patent EP1572962.
JD520013 - Sequence 501037 from Patent EP1572962.
JD213918 - Sequence 194942 from Patent EP1572962.
JD213625 - Sequence 194649 from Patent EP1572962.
JD212265 - Sequence 193289 from Patent EP1572962.
JD466794 - Sequence 447818 from Patent EP1572962.
JD435530 - Sequence 416554 from Patent EP1572962.
JD308323 - Sequence 289347 from Patent EP1572962.
JD256201 - Sequence 237225 from Patent EP1572962.
JD077594 - Sequence 58618 from Patent EP1572962.
JD309365 - Sequence 290389 from Patent EP1572962.
JD554972 - Sequence 535996 from Patent EP1572962.
JD100189 - Sequence 81213 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00190 - Oxidative phosphorylation
hsa01100 - Metabolic pathways
hsa05010 - Alzheimer's disease
hsa05012 - Parkinson's disease
hsa05016 - Huntington's disease

Reactome (by CSHL, EBI, and GO)

Protein O43674 (Reactome details) participates in the following event(s):

R-HSA-6799178 Intermediate 1 binds HP subcomplex to form Intermediate 2
R-HSA-6799191 Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex
R-HSA-6799202 The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex
R-HSA-6799197 ND4, ND5 bind the 550kDa complex to form the 815kDa complex
R-HSA-6799179 Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
R-HSA-6799196 The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I
R-HSA-163217 Complex I oxidises NADH to NAD+, reduces CoQ to QH2
R-HSA-6799198 Complex I biogenesis
R-HSA-611105 Respiratory electron transport
R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: NDUB5_HUMAN, NM_002492, O43674, Q561V6, uc003fkc.1, uc003fkc.2, uc003fkc.3, uc003fkc.4, uc003fkc.5
UCSC ID: uc003fkc.5
RefSeq Accession: NM_002492
Protein: O43674 (aka NDUB5_HUMAN)
CCDS: CCDS3234.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.