Human Gene DMAC2L (ENST00000245448.10) Description and Page Index
Description: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity). (from UniProt Q99766) RefSeq Summary (NM_001003805): This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000245448.10 Gencode Gene: ENSG00000125375.15 Transcript (Including UTRs) Position: hg38 chr14:50,312,329-50,326,226 Size: 13,898 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr14:50,313,021-50,325,631 Size: 12,611 Coding Exon Count: 4
ID:ATP5S_HUMAN DESCRIPTION: RecName: Full=ATP synthase subunit s, mitochondrial; AltName: Full=ATP synthase-coupling factor B; Short=FB; AltName: Full=Mitochondrial ATP synthase regulatory component factor B; Flags: Precursor; FUNCTION: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity). SUBUNIT: Homotetramer. Associates with ATP synthase (By similarity). SUBCELLULAR LOCATION: Mitochondrion (By similarity). Mitochondrion inner membrane (By similarity). SIMILARITY: Belongs to the ATP synthase subunit s family. SIMILARITY: Contains 4 LRR (leucine-rich) repeats. CAUTION: It is uncertain whether Met-1 or Met-16 is the initiator.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Highest median expression: 15.21 RPKM in Testis
Total median expression: 196.69 RPKM
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99766
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.