Human Gene RHOQ (ENST00000238738.9) from GENCODE V41
Description: Homo sapiens ras homolog family member Q (RHOQ), mRNA. (from RefSeq NM_012249) RefSeq Summary (NM_012249): This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]. Gencode Transcript: ENST00000238738.9 Gencode Gene: ENSG00000119729.12 Transcript (Including UTRs) Position: hg38 chr2:46,542,490-46,584,688 Size: 42,199 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr2:46,543,047-46,581,083 Size: 38,037 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.