Human Gene RHOQ (ENST00000238738.9) from GENCODE V41
  Description: Homo sapiens ras homolog family member Q (RHOQ), mRNA. (from RefSeq NM_012249)
RefSeq Summary (NM_012249): This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011].
Gencode Transcript: ENST00000238738.9
Gencode Gene: ENSG00000119729.12
Transcript (Including UTRs)
   Position: hg38 chr2:46,542,490-46,584,688 Size: 42,199 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr2:46,543,047-46,581,083 Size: 38,037 Coding Exon Count: 5 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2022-05-14 18:57:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:46,542,490-46,584,688)mRNA (may differ from genome)Protein (205 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSCGAPEnsemblEntrez GeneExonPrimerGencode
GeneCardsHGNCHPRDLynxMGIOMIM
PubMedUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D014212 Tretinoin
  • D000082 Acetaminophen
  • D004997 Ethinyl Estradiol
  • D013749 Tetrachlorodibenzodioxin
  • D014635 Valproic Acid
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • C547126 AZM551248
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.74 RPKM in Heart - Left Ventricle
Total median expression: 272.86 RPKM


View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -389.60557-0.699 Picture PostScript Text
3' UTR -825.523605-0.229 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  EU794657 - Homo sapiens epididymis secretory protein Li 42 (HEL-S-42) mRNA, complete cds.
AK095329 - Homo sapiens cDNA FLJ38010 fis, clone CTONG2012476, weakly similar to GTP-BINDING PROTEIN TC10.
BC056154 - Homo sapiens ras homolog gene family, member Q, mRNA (cDNA clone MGC:65057 IMAGE:5539023), complete cds.
BC070485 - Homo sapiens ras homolog gene family, member Q, mRNA (cDNA clone MGC:87976 IMAGE:6010516), complete cds.
BC065291 - Homo sapiens ras homolog gene family, member Q, mRNA (cDNA clone MGC:75044 IMAGE:6061807), complete cds.
BC013135 - Homo sapiens ras homolog gene family, member Q, mRNA (cDNA clone IMAGE:4524079), **** WARNING: chimeric clone ****.
BC101806 - Homo sapiens ras homolog gene family, member Q, mRNA (cDNA clone MGC:126855 IMAGE:8069312), complete cds.
BC093805 - Homo sapiens ras homolog gene family, member Q, mRNA (cDNA clone MGC:120840 IMAGE:7939650), complete cds.
AF498976 - Homo sapiens small GTP binding protein TC10 (TC10) mRNA, complete cds.
M31470 - Human ras-like protein mRNA, complete cds, clone TC10.
KJ893373 - Synthetic construct Homo sapiens clone ccsbBroadEn_02767 RHOQ gene, encodes complete protein.
AB528045 - Synthetic construct DNA, clone: pF1KB6915, Homo sapiens RHOQ gene for ras homolog gene family, member Q, without stop codon, in Flexi system.
CU688645 - Synthetic construct Homo sapiens gateway clone IMAGE:100022132 3' read PIGF mRNA.
JD262337 - Sequence 243361 from Patent EP1572962.
JD281097 - Sequence 262121 from Patent EP1572962.
JD382697 - Sequence 363721 from Patent EP1572962.
JD237429 - Sequence 218453 from Patent EP1572962.
JD091139 - Sequence 72163 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04910 - Insulin signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000238738.1, ENST00000238738.2, ENST00000238738.3, ENST00000238738.4, ENST00000238738.5, ENST00000238738.6, ENST00000238738.7, ENST00000238738.8, NM_012249, uc002rva.1, uc002rva.2, uc002rva.3, uc002rva.4, uc002rva.5, V9HWD0
UCSC ID: ENST00000238738.9
RefSeq Accession: NM_012249
CCDS: CCDS33191.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.