Human Gene KAT8 (ENST00000219797.9) Description and Page Index
Description: Homo sapiens lysine acetyltransferase 8 (KAT8), transcript variant 1, mRNA. (from RefSeq NM_032188) RefSeq Summary (NM_032188): This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]. Gencode Transcript: ENST00000219797.9 Gencode Gene: ENSG00000103510.20 Transcript (Including UTRs) Position: hg38 chr16:31,117,664-31,131,359 Size: 13,696 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr16:31,117,682-31,131,259 Size: 13,578 Coding Exon Count: 11
ID:KAT8_HUMAN DESCRIPTION: RecName: Full=Histone acetyltransferase KAT8; EC=22.214.171.124; AltName: Full=Lysine acetyltransferase 8; AltName: Full=MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; Short=MYST-1; Short=hMOF; FUNCTION: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone]. SUBUNIT: Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM through the chromodomain. Interacts with KANSL1; the interaction is direct. INTERACTION: Q03164:MLL; NbExp=3; IntAct=EBI-896414, EBI-591370; Q99496:RNF2; NbExp=2; IntAct=EBI-896414, EBI-722416; SUBCELLULAR LOCATION: Nucleus. Chromosome (By similarity). PTM: Autoacetylation at Lys-274 is required for proper function. SIMILARITY: Belongs to the MYST (SAS/MOZ) family. SIMILARITY: Contains 1 C2HC-type zinc finger. SIMILARITY: Contains 1 chromo domain. SEQUENCE CAUTION: Sequence=AAL55762.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAL56648.1; Type=Frameshift; Positions=23, 26, 52;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H7Z6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.