Human Gene GCC2 (ENST00000309863.11) from GENCODE V44
Description: Homo sapiens GRIP and coiled-coil domain containing 2 (GCC2), transcript variant 1, mRNA. (from RefSeq NM_181453) RefSeq Summary (NM_181453): The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]. Gencode Transcript: ENST00000309863.11 Gencode Gene: ENSG00000135968.22 Transcript (Including UTRs) Position: hg38 chr2:108,449,206-108,509,415 Size: 60,210 Total Exon Count: 23 Strand: + Coding Region Position: hg38 chr2:108,449,275-108,507,630 Size: 58,356 Coding Exon Count: 23
ID:GCC2_HUMAN DESCRIPTION: RecName: Full=GRIP and coiled-coil domain-containing protein 2; AltName: Full=185 kDa Golgi coiled-coil protein; Short=GCC185; AltName: Full=CLL-associated antigen KW-11; AltName: Full=CTCL tumor antigen se1-1; AltName: Full=Ran-binding protein 2-like 4; Short=RanBP2L4; AltName: Full=Renal carcinoma antigen NY-REN-53; FUNCTION: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. SUBUNIT: Homodimer. Interacts (via GRIP domain) with RAB6A (preferentially in its GTP-bound form). May interact (RAB6A- dependent) with ARL1; according to PubMed:19703403, RAB6A and ARL1 are not involved in GCC2 Golgi localization as proposed by PubMed:18243103. Interacts (probably via GRIP domain) with RAB9A (preferentially in its GTP-bound form). Interacts with CLASP1 and CLASP2; recruits both proteins to membranes of the TGN. Interacts with STX16. INTERACTION: Self; NbExp=2; IntAct=EBI-1645320, EBI-1645320; P20340:RAB6A; NbExp=4; IntAct=EBI-1645320, EBI-1052826; SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: Extended rod-like protein with coiled-coil domains. SIMILARITY: Contains 1 GRIP domain. SEQUENCE CAUTION: Sequence=AAG34902.1; Type=Frameshift; Positions=694, 700, 937, 940; Sequence=AAH37774.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS; Sequence=AAI46790.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS; Sequence=AAL99918.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAX88838.1; Type=Erroneous gene model prediction; Sequence=BAA20794.2; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS; Sequence=EAW53882.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IWJ2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0042802 identical protein binding
Biological Process: GO:0006622 protein targeting to lysosome GO:0015031 protein transport GO:0031023 microtubule organizing center organization GO:0034067 protein localization to Golgi apparatus GO:0034453 microtubule anchoring GO:0034499 late endosome to Golgi transport GO:0042147 retrograde transport, endosome to Golgi GO:0070861 regulation of protein exit from endoplasmic reticulum GO:0071955 recycling endosome to Golgi transport GO:0090161 Golgi ribbon formation GO:0043001 Golgi to plasma membrane protein transport
AK090813 - Homo sapiens cDNA FLJ33494 fis, clone BRAMY2003898, highly similar to Homo sapiens GRIP and coiled-coil domain containing 2 (GCC2), transcript variant 1, mRNA. AX746628 - Sequence 153 from Patent EP1308459. BC037774 - Homo sapiens GRIP and coiled-coil domain containing 2, mRNA (cDNA clone IMAGE:5276271), partial cds. AF432211 - Homo sapiens CLL-associated antigen KW-11 mRNA, partial cds. AB002334 - Homo sapiens mRNA for KIAA0336 gene, partial cds. BC146789 - Homo sapiens GRIP and coiled-coil domain containing 2, mRNA (cDNA clone MGC:166883 IMAGE:9007253), complete cds. AK308707 - Homo sapiens cDNA, FLJ98748. BC020645 - Homo sapiens GRIP and coiled-coil domain containing 2, mRNA (cDNA clone IMAGE:4659829), partial cds. AB384463 - Synthetic construct DNA, clone: pF1KA0336, Homo sapiens GCC2 gene for Ran-binding protein 2-like 4, complete cds, without stop codon, in Flexi system. KJ904629 - Synthetic construct Homo sapiens clone ccsbBroadEn_14023 GCC2 gene, encodes complete protein. AF273042 - Homo sapiens CTCL tumor antigen se1-1 mRNA, complete cds. JD283619 - Sequence 264643 from Patent EP1572962. JD104719 - Sequence 85743 from Patent EP1572962. JD392037 - Sequence 373061 from Patent EP1572962. JD354696 - Sequence 335720 from Patent EP1572962. JD415801 - Sequence 396825 from Patent EP1572962. JD511935 - Sequence 492959 from Patent EP1572962. JD209604 - Sequence 190628 from Patent EP1572962. JD268289 - Sequence 249313 from Patent EP1572962. JD480039 - Sequence 461063 from Patent EP1572962. JD291656 - Sequence 272680 from Patent EP1572962. JD467208 - Sequence 448232 from Patent EP1572962. JD548947 - Sequence 529971 from Patent EP1572962. JD495603 - Sequence 476627 from Patent EP1572962. JD265265 - Sequence 246289 from Patent EP1572962. JD174153 - Sequence 155177 from Patent EP1572962. JD324910 - Sequence 305934 from Patent EP1572962. JD415430 - Sequence 396454 from Patent EP1572962. JD280306 - Sequence 261330 from Patent EP1572962. JD224373 - Sequence 205397 from Patent EP1572962. JD185465 - Sequence 166489 from Patent EP1572962. JD366792 - Sequence 347816 from Patent EP1572962. JD149548 - Sequence 130572 from Patent EP1572962. JD117663 - Sequence 98687 from Patent EP1572962. JD146535 - Sequence 127559 from Patent EP1572962. JD268562 - Sequence 249586 from Patent EP1572962. JD367735 - Sequence 348759 from Patent EP1572962. JD537690 - Sequence 518714 from Patent EP1572962. JD160007 - Sequence 141031 from Patent EP1572962. JD214070 - Sequence 195094 from Patent EP1572962. JD439942 - Sequence 420966 from Patent EP1572962. JD279456 - Sequence 260480 from Patent EP1572962. JD352660 - Sequence 333684 from Patent EP1572962. JD244388 - Sequence 225412 from Patent EP1572962. JD503810 - Sequence 484834 from Patent EP1572962. JD503809 - Sequence 484833 from Patent EP1572962. JD510014 - Sequence 491038 from Patent EP1572962. JD350420 - Sequence 331444 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8IWJ2 (Reactome details) participates in the following event(s):
R-HSA-6814674 Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins R-HSA-6814091 ARL1 recruits TGN Golgin homodimers R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport