Human Gene ZNF133 (uc010gcs.3)
  Description: Homo sapiens zinc finger protein 133 (ZNF133), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr20:18,269,121-18,297,640 Size: 28,520 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr20:18,286,331-18,297,460 Size: 11,130 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:18,269,121-18,297,640)mRNA (may differ from genome)Protein (653 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMalacardsMGI
OMIMPubMedReactomeTreefamUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF133
Diseases sorted by gene-association score: corneal dystrophy, posterior polymorphous, 1 (10), osteoblastoma (9), split hand-foot malformation 1 (9), bone benign neoplasm (6), connective tissue benign neoplasm (5), alagille syndrome 1 (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.68 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 256.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -65.50147-0.446 Picture PostScript Text
3' UTR -50.60180-0.281 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on P52736-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  BC001887 - Homo sapiens zinc finger protein 133, mRNA (cDNA clone MGC:1579 IMAGE:3535533), complete cds.
AK295273 - Homo sapiens cDNA FLJ56079 complete cds, highly similar to Zinc finger protein 133.
AK295513 - Homo sapiens cDNA FLJ61274 complete cds, highly similar to Zinc finger protein 133.
AK291389 - Homo sapiens cDNA FLJ77414 complete cds, highly similar to Homo sapiens zinc finger protein 133 (clone pHZ-13) (ZNF133), mRNA.
AK316386 - Homo sapiens cDNA, FLJ79285 complete cds, highly similar to Zinc finger protein 133.
AK313525 - Homo sapiens cDNA, FLJ94083.
AK294263 - Homo sapiens cDNA FLJ61226 complete cds, highly similar to Zinc finger protein 133.
U09366 - Human zinc finger protein ZNF133.
AK074502 - Homo sapiens cDNA FLJ90021 fis, clone HEMBA1000875.
CU674910 - Synthetic construct Homo sapiens gateway clone IMAGE:100017758 5' read ZNF133 mRNA.
KJ897770 - Synthetic construct Homo sapiens clone ccsbBroadEn_07164 ZNF133 gene, encodes complete protein.
AB385083 - Synthetic construct DNA, clone: pF1KB5335, Homo sapiens ZNF133 gene for zinc finger protein 133, complete cds, without stop codon, in Flexi system.
BT007310 - Homo sapiens zinc finger protein 133 (clone pHZ-13) mRNA, complete cds.
AK123005 - Homo sapiens cDNA FLJ16801 fis, clone TESTI4004626, highly similar to Zinc finger protein 133.
DQ598046 - Homo sapiens piRNA piR-36112, complete sequence.
JD083969 - Sequence 64993 from Patent EP1572962.
JD419161 - Sequence 400185 from Patent EP1572962.
JD313001 - Sequence 294025 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P52736 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001083330, NP_003425, P52736-2, ZNF150
UCSC ID: uc010gcs.3
RefSeq Accession: NM_001083330
Protein: P52736-2 CCDS: CCDS13134.1, CCDS63234.1, CCDS63233.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001083330.1
exon count: 4CDS single in 3' UTR: no RNA size: 2306
ORF size: 1962CDS single in intron: no Alignment % ID: 99.96
txCdsPredict score: 4124.00frame shift in genome: no % Coverage: 99.26
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.