Description: Homo sapiens PAXIP1 associated glutamate-rich protein 1 (PAGR1), mRNA. RefSeq Summary (NM_024516): C16ORF53 (PA1) is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007 [PubMed 17500065]).[supplied by OMIM, May 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Transcript (Including UTRs) Position: hg19 chr16:29,827,528-29,833,816 Size: 6,289 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr16:29,827,847-29,831,075 Size: 3,229 Coding Exon Count: 3
ID:PAGR1_HUMAN DESCRIPTION: RecName: Full=PAXIP1-associated glutamate-rich protein 1; AltName: Full=PAXIP1-associated protein 1; AltName: Full=PTIP-associated protein 1; SUBUNIT: Interacts with PAXIP1/PTIP; the interaction is direct and is required for the association with the rest of the PTIP complex. Component of the MLL2/MLL3 complex (also named ASCOM complex), at least composed of MLL2/ALR or MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. INTERACTION: Q6ZW49:PAXIP1; NbExp=5; IntAct=EBI-2372223, EBI-743225;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF15364 - PAXIP1-associated-protein-1 C term PTIP binding protein
ModBase Predicted Comparative 3D Structure on Q9BTK6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK226151 - Homo sapiens mRNA for hypothetical protein LOC112476 variant, clone: fk13667. EF195235 - Homo sapiens PTIP-associated 1 protein mRNA, complete cds. BC003640 - Homo sapiens chromosome 16 open reading frame 53, mRNA (cDNA clone MGC:4606 IMAGE:3356565), complete cds. CU678552 - Synthetic construct Homo sapiens gateway clone IMAGE:100018613 5' read C16orf53 mRNA. HQ447362 - Synthetic construct Homo sapiens clone IMAGE:100070683; CCSB003927_02 chromosome 16 open reading frame 53 (C16orf53) gene, encodes complete protein. KJ894681 - Synthetic construct Homo sapiens clone ccsbBroadEn_04075 C16orf53 gene, encodes complete protein. JD367860 - Sequence 348884 from Patent EP1572962. JD271751 - Sequence 252775 from Patent EP1572962. JD151034 - Sequence 132058 from Patent EP1572962. JD146326 - Sequence 127350 from Patent EP1572962. JD253042 - Sequence 234066 from Patent EP1572962. JD409860 - Sequence 390884 from Patent EP1572962. JD168879 - Sequence 149903 from Patent EP1572962. AK026112 - Homo sapiens cDNA: FLJ22459 fis, clone HRC10045. AK310168 - Homo sapiens cDNA, FLJ17210. AK301130 - Homo sapiens cDNA FLJ54179 complete cds. AK298238 - Homo sapiens cDNA FLJ53437 complete cds, highly similar to Major vault protein. AJ291366 - Homo sapiens partial mRNA for major vault protein (MVP gene), splice variant 1. AJ291367 - Homo sapiens partial mRNA for major vault protein (MVP gene) and upstream open reading frame (uORF), splice variant 2. X79882 - Homo sapiens lrp mRNA. HM005570 - Homo sapiens clone HTL-S-30 testicular secretory protein Li 30 mRNA, complete cds. AK293302 - Homo sapiens cDNA FLJ54588 complete cds, highly similar to Major vault protein. AK302052 - Homo sapiens cDNA FLJ53371 complete cds, highly similar to Major vault protein. BC015623 - Homo sapiens major vault protein, mRNA (cDNA clone MGC:22969 IMAGE:4843712), complete cds. JD564341 - Sequence 545365 from Patent EP1572962. JD319342 - Sequence 300366 from Patent EP1572962. JD383859 - Sequence 364883 from Patent EP1572962. JD420981 - Sequence 402005 from Patent EP1572962. JD420980 - Sequence 402004 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BTK6 (Reactome details) participates in the following event(s):
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5619507 Activation of HOX genes during differentiation R-HSA-1266738 Developmental Biology