Human Gene MUC19 (uc009zjx.1)
  Description: SubName: Full=Mucin-19; Flags: Fragment;
Transcript (Including UTRs)
   Position: hg19 chr12:40,938,852-40,957,362 Size: 18,511 Total Exon Count: 22 Strand: +
Coding Region
   Position: hg19 chr12:40,938,857-40,957,361 Size: 18,505 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:40,938,852-40,957,362)mRNA (may differ from genome)Protein (373 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
EnsemblExonPrimerGeneCardsH-INVHGNCLynx
MalacardsMGIPubMedTreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: J3QSZ1_HUMAN
DESCRIPTION: SubName: Full=Mucin-19; Flags: Fragment;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MUC19
CDC HuGE Published Literature: MUC19
Positive Disease Associations: Crohn's disease
Related Studies:
  1. Crohn's disease
    Barrett ,et al. 2008, Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease, Nature genetics 2008 40- 8 : 955-62. [PubMed 18587394]

-  MalaCards Disease Associations
  MalaCards Gene Search: MUC19
Diseases sorted by gene-association score: colorectal cancer 1 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.69 RPKM in Minor Salivary Gland
Total median expression: 7.45 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006208 - Cys_knot
IPR006207 - Cys_knot_C
IPR001007 - VWF_C

ModBase Predicted Comparative 3D Structure on J3QSZ1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  HM801842 - Homo sapiens MUC19 variant 12 (MUC19) mRNA, complete cds, alternatively spliced.
AY236870 - Homo sapiens MUC19 mRNA, partial cds.
AK093065 - Homo sapiens cDNA FLJ35746 fis, clone TESTI2004399, moderately similar to APOMUCIN.
AX747898 - Sequence 1423 from Patent EP1308459.
JD511318 - Sequence 492342 from Patent EP1572962.
JD319120 - Sequence 300144 from Patent EP1572962.
JD350838 - Sequence 331862 from Patent EP1572962.
JD163255 - Sequence 144279 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AY236870, J3QSZ1, J3QSZ1_HUMAN
UCSC ID: uc009zjx.1
Representative RNA: AY236870
Protein: J3QSZ1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AY236870.1
exon count: 22CDS single in 3' UTR: no RNA size: 2230
ORF size: 1119CDS single in intron: no Alignment % ID: 99.91
txCdsPredict score: 2287.00frame shift in genome: no % Coverage: 50.45
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.