Human Gene MPRIP (uc002gqy.2)
  Description: Homo sapiens myosin phosphatase Rho interacting protein (MPRIP), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:17,067,974-17,095,962 Size: 27,989 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr17:17,068,380-17,088,208 Size: 19,829 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:17,067,974-17,095,962)mRNA (may differ from genome)Protein (1267 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCLynxMGIPubMedTreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: H0Y2S9_HUMAN
DESCRIPTION: SubName: Full=Myosin phosphatase Rho-interacting protein;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.28 RPKM in Artery - Tibial
Total median expression: 959.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -191.90406-0.473 Picture PostScript Text
3' UTR -2772.597754-0.358 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013326 - ApoA/E_ApoLp

Pfam Domains:
PF01442 - Apolipoprotein A1/A4/E domain

ModBase Predicted Comparative 3D Structure on H0Y2S9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005829 cytosol
GO:0015629 actin cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  LF209088 - JP 2014500723-A/16591: Polycomb-Associated Non-Coding RNAs.
KF724384 - Homo sapiens myosin phosphatase Rho interacting protein/high affinity nerve growth factor receptor 1 fusion protein (MPRIP-NTRK1 fusion) mRNA, complete cds.
LF384741 - JP 2014500723-A/192244: Polycomb-Associated Non-Coding RNAs.
BC136479 - Homo sapiens myosin phosphatase Rho interacting protein, mRNA (cDNA clone MGC:168091 IMAGE:9020468), complete cds.
AB098507 - Homo sapiens RHOIP3 mRNA for Rho-interacting protein 3, complete cds.
AB384537 - Synthetic construct DNA, clone: pF1KA0864, Homo sapiens MRIP gene for myosin phosphatase Rho-interacting protein, complete cds, without stop codon, in Flexi system.
AY296247 - Homo sapiens myosin phosphatase-Rho interacting protein mRNA, complete cds.
AB189741 - Homo sapiens p116Rip mRNA for Rho interacting protein, complete cds.
AL834513 - Homo sapiens mRNA; cDNA DKFZp762J227 (from clone DKFZp762J227).
BC063588 - Homo sapiens myosin phosphatase-Rho interacting protein, mRNA (cDNA clone IMAGE:4441347), partial cds.
BC014102 - Homo sapiens myosin phosphatase-Rho interacting protein, mRNA (cDNA clone IMAGE:3532724), partial cds.
BC009982 - Homo sapiens myosin phosphatase Rho interacting protein, mRNA (cDNA clone IMAGE:4121355), partial cds.
KX075429 - Homo sapiens isolate PB_Subject10 clone 1208-10 T-cell receptor beta chain variable region (TRB) mRNA, partial cds.
MA620318 - JP 2018138019-A/192244: Polycomb-Associated Non-Coding RNAs.
MA444665 - JP 2018138019-A/16591: Polycomb-Associated Non-Coding RNAs.
AK092287 - Homo sapiens cDNA FLJ34968 fis, clone NTONG2004844, highly similar to P116 RHO-INTERACTING PROTEIN.
AX747452 - Sequence 977 from Patent EP1308459.
BC075847 - Homo sapiens myosin phosphatase Rho interacting protein, mRNA (cDNA clone IMAGE:6377500), partial cds.
BC105987 - Homo sapiens myosin phosphatase Rho interacting protein, mRNA (cDNA clone IMAGE:4363480), partial cds.
AK025229 - Homo sapiens cDNA: FLJ21576 fis, clone COL06715, highly similar to HUMIRS Human mRNA clone HH109 (screened by the monoclonal antibody of insulin receptor substrate-1 (IRS-1)).
BC021058 - Homo sapiens myosin phosphatase Rho interacting protein, mRNA (cDNA clone IMAGE:2961049).
BC021070 - Homo sapiens myosin phosphatase Rho interacting protein, mRNA (cDNA clone IMAGE:2961120).
D23673 - Homo sapiens mRNA, clone HH109, screened by the monoclonal antibody of insulin receptor substrate-1 (IRS-1).
AB020671 - Homo sapiens mRNA for KIAA0864 protein, partial cds.
JD470375 - Sequence 451399 from Patent EP1572962.
LF326023 - JP 2014500723-A/133526: Polycomb-Associated Non-Coding RNAs.
JD205523 - Sequence 186547 from Patent EP1572962.
JD150262 - Sequence 131286 from Patent EP1572962.
LF326024 - JP 2014500723-A/133527: Polycomb-Associated Non-Coding RNAs.
LF326025 - JP 2014500723-A/133528: Polycomb-Associated Non-Coding RNAs.
AK025604 - Homo sapiens cDNA: FLJ21951 fis, clone HEP04968.
BC050323 - Homo sapiens myosin phosphatase Rho interacting protein, mRNA (cDNA clone IMAGE:5265017), with apparent retained intron.
LF326026 - JP 2014500723-A/133529: Polycomb-Associated Non-Coding RNAs.
AK026247 - Homo sapiens cDNA: FLJ22594 fis, clone HSI03267.
DQ570736 - Homo sapiens piRNA piR-30848, complete sequence.
LF326028 - JP 2014500723-A/133531: Polycomb-Associated Non-Coding RNAs.
AB362572 - Homo sapiens M-RIP mRMA for myosin phosphatase-Rho interacting protein, partial cds, splicing variant 1.
AB362573 - Homo sapiens M-RIP mRMA for myosin phosphatase-Rho interacting protein, partial cds, splicing variant 2.
DQ570645 - Homo sapiens piRNA piR-30757, complete sequence.
AJ844625 - Homo sapiens partial mRNA for myosin phosphatase-Rho interacting protein (M-RIP gene).
BC012426 - Homo sapiens myosin phosphatase Rho interacting protein, mRNA (cDNA clone IMAGE:3857014), partial cds.
BC030255 - Homo sapiens myosin phosphatase Rho interacting protein, mRNA (cDNA clone IMAGE:4185424), with apparent retained intron.
LF326031 - JP 2014500723-A/133534: Polycomb-Associated Non-Coding RNAs.
DQ598455 - Homo sapiens piRNA piR-36521, complete sequence.
JD073043 - Sequence 54067 from Patent EP1572962.
LF326033 - JP 2014500723-A/133536: Polycomb-Associated Non-Coding RNAs.
DQ588782 - Homo sapiens piRNA piR-55894, complete sequence.
DQ573259 - Homo sapiens piRNA piR-41371, complete sequence.
LF326036 - JP 2014500723-A/133539: Polycomb-Associated Non-Coding RNAs.
LF326037 - JP 2014500723-A/133540: Polycomb-Associated Non-Coding RNAs.
DQ586364 - Homo sapiens piRNA piR-53476, complete sequence.
JD271575 - Sequence 252599 from Patent EP1572962.
DQ594517 - Homo sapiens piRNA piR-60629, complete sequence.
DQ584229 - Homo sapiens piRNA piR-51341, complete sequence.
JD074149 - Sequence 55173 from Patent EP1572962.
JD488192 - Sequence 469216 from Patent EP1572962.
AK091337 - Homo sapiens cDNA FLJ34018 fis, clone FCBBF2002801.
AK026035 - Homo sapiens cDNA: FLJ22382 fis, clone HRC07514.
MA561600 - JP 2018138019-A/133526: Polycomb-Associated Non-Coding RNAs.
MA561601 - JP 2018138019-A/133527: Polycomb-Associated Non-Coding RNAs.
MA561602 - JP 2018138019-A/133528: Polycomb-Associated Non-Coding RNAs.
MA561603 - JP 2018138019-A/133529: Polycomb-Associated Non-Coding RNAs.
MA561605 - JP 2018138019-A/133531: Polycomb-Associated Non-Coding RNAs.
MA561608 - JP 2018138019-A/133534: Polycomb-Associated Non-Coding RNAs.
MA561610 - JP 2018138019-A/133536: Polycomb-Associated Non-Coding RNAs.
MA561613 - JP 2018138019-A/133539: Polycomb-Associated Non-Coding RNAs.
MA561614 - JP 2018138019-A/133540: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BC050323, H0Y2S9, H0Y2S9_HUMAN
UCSC ID: uc002gqy.2
RefSeq Accession: NM_015134
Protein: H0Y2S9

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC050323.1
exon count: 9CDS single in 3' UTR: no RNA size: 3747
ORF size: 3804CDS single in intron: no Alignment % ID: 99.71
txCdsPredict score: 7751.00frame shift in genome: no % Coverage: 99.63
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.