Description: Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNA. RefSeq Summary (NM_002166): The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]. Transcript (Including UTRs) Position: hg19 chr2:8,822,113-8,824,583 Size: 2,471 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr2:8,822,296-8,823,029 Size: 734 Coding Exon Count: 2
ID:ID2_HUMAN DESCRIPTION: RecName: Full=DNA-binding protein inhibitor ID-2; AltName: Full=Class B basic helix-loop-helix protein 26; Short=bHLHb26; AltName: Full=Inhibitor of DNA binding 2; FUNCTION: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. SUBUNIT: Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5 (By similarity). Interacts with NR0B2. INTERACTION: P15923-1:TCF3; NbExp=3; IntAct=EBI-713450, EBI-769645; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus. TISSUE SPECIFICITY: Highly expressed in early fetal tissues, including those of the central nervous system. DEVELOPMENTAL STAGE: Found in most early fetal tissues but not in the corresponding mature tissues. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ID2 CDC HuGE Published Literature: ID2 Positive Disease Associations: Survival Related Studies:
Survival Kathryn L Lunetta et al. BMC medical genetics 2007, Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study., BMC medical genetics.
[PubMed 17903295]
Longevity and aging traits are associated with SNPs on the Affymetrix 100K GeneChip. None of the associations achieved genome-wide significance. These data generate hypotheses and serve as a resource for replication as more genes and biologic pathways are proposed as contributing to longevity and healthy aging.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q02363
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0044325 ion channel binding GO:0046983 protein dimerization activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001656 metanephros development GO:0001779 natural killer cell differentiation GO:0001966 thigmotaxis GO:0002521 leukocyte differentiation GO:0003149 membranous septum morphogenesis GO:0003166 bundle of His development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0007507 heart development GO:0007623 circadian rhythm GO:0008344 adult locomotory behavior GO:0009649 entrainment of circadian clock GO:0010628 positive regulation of gene expression GO:0010629 negative regulation of gene expression GO:0014003 oligodendrocyte development GO:0019216 regulation of lipid metabolic process GO:0021772 olfactory bulb development GO:0032922 circadian regulation of gene expression GO:0033598 mammary gland epithelial cell proliferation GO:0042752 regulation of circadian rhythm GO:0043153 entrainment of circadian clock by photoperiod GO:0043353 enucleate erythrocyte differentiation GO:0043392 negative regulation of DNA binding GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0045475 locomotor rhythm GO:0045578 negative regulation of B cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045648 positive regulation of erythrocyte differentiation GO:0045651 positive regulation of macrophage differentiation GO:0045665 negative regulation of neuron differentiation GO:0045668 negative regulation of osteoblast differentiation GO:0045777 positive regulation of blood pressure GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0048468 cell development GO:0048469 cell maturation GO:0048511 rhythmic process GO:0048541 Peyer's patch development GO:0048557 embryonic digestive tract morphogenesis GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048663 neuron fate commitment GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048711 positive regulation of astrocyte differentiation GO:0048715 negative regulation of oligodendrocyte differentiation GO:0060612 adipose tissue development GO:0060749 mammary gland alveolus development GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development GO:0061031 endodermal digestive tract morphogenesis GO:0071158 positive regulation of cell cycle arrest GO:0071285 cellular response to lithium ion GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0090398 cellular senescence GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000178 negative regulation of neural precursor cell proliferation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
