Human Gene GNL2 (uc001cbk.3)
  Description: Homo sapiens guanine nucleotide binding protein-like 2 (nucleolar) (GNL2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:38,032,413-38,061,586 Size: 29,174 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chr1:38,032,456-38,061,423 Size: 28,968 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:38,032,413-38,061,586)mRNA (may differ from genome)Protein (731 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NOG2_HUMAN
DESCRIPTION: RecName: Full=Nucleolar GTP-binding protein 2; AltName: Full=Autoantigen NGP-1;
FUNCTION: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity).
SUBCELLULAR LOCATION: Nucleus, nucleolus.
TISSUE SPECIFICITY: Ubiquitously expressed at relatively low levels in all human tissues tested, with the highest level of expression in the testes.
SIMILARITY: Belongs to the MMR1/HSR1 GTP-binding protein family. NOG2 subfamily.
SIMILARITY: Contains 1 G (guanine nucleotide-binding) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.58 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 346.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -64.80163-0.398 Picture PostScript Text
3' UTR -1.1043-0.026 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023179 - GTP-bd_ortho_bundle
IPR006073 - GTP_binding_domain
IPR024929 - NOG2
IPR012971 - NOG2_N_dom

Pfam Domains:
PF01926 - 50S ribosome-binding GTPase
PF02421 - Ferrous iron transport protein B
PF08153 - NGP1NT (NUC091) domain

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q13823
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene Details  Gene DetailsGene DetailsGene Details
Gene Sorter  Gene SorterGene SorterGene Sorter
  EnsemblFlyBaseWormBaseSGD
  Protein SequenceProtein SequenceProtein SequenceProtein Sequence
  AlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005525 GTP binding

Biological Process:
GO:0008150 biological_process
GO:0042254 ribosome biogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  LF206612 - JP 2014500723-A/14115: Polycomb-Associated Non-Coding RNAs.
LF206611 - JP 2014500723-A/14114: Polycomb-Associated Non-Coding RNAs.
LF356571 - JP 2014500723-A/164074: Polycomb-Associated Non-Coding RNAs.
L05425 - Homo sapiens nucleolar GTPase mRNA, complete cds.
BC000107 - Homo sapiens guanine nucleotide binding protein-like 2 (nucleolar), mRNA (cDNA clone MGC:1085 IMAGE:3506131), complete cds.
AK130697 - Homo sapiens cDNA FLJ27187 fis, clone SYN02458.
BC009250 - Homo sapiens guanine nucleotide binding protein-like 2 (nucleolar), mRNA (cDNA clone MGC:4453 IMAGE:2960125), complete cds.
AK312915 - Homo sapiens cDNA, FLJ93364, Homo sapiens nucleolar GTPase (HUMAUANTIG), mRNA.
DQ892183 - Synthetic construct clone IMAGE:100004813; FLH183784.01X; RZPDo839G07142D guanine nucleotide binding protein-like 2 (nucleolar) (GNL2) gene, encodes complete protein.
KJ893704 - Synthetic construct Homo sapiens clone ccsbBroadEn_03098 GNL2 gene, encodes complete protein.
KJ898738 - Synthetic construct Homo sapiens clone ccsbBroadEn_08132 GNL2 gene, encodes complete protein.
EU176692 - Synthetic construct Homo sapiens clone IMAGE:100011467; FLH183783.01L; RZPDo839F04255D guanine nucleotide binding protein-like 2 (nucleolar) (GNL2) gene, encodes complete protein.
LF356570 - JP 2014500723-A/164073: Polycomb-Associated Non-Coding RNAs.
LF356569 - JP 2014500723-A/164072: Polycomb-Associated Non-Coding RNAs.
LF356568 - JP 2014500723-A/164071: Polycomb-Associated Non-Coding RNAs.
LF356566 - JP 2014500723-A/164069: Polycomb-Associated Non-Coding RNAs.
LF356565 - JP 2014500723-A/164068: Polycomb-Associated Non-Coding RNAs.
AK298358 - Homo sapiens cDNA FLJ54985 complete cds, highly similar to Nucleolar GTP-binding protein 2.
LF356564 - JP 2014500723-A/164067: Polycomb-Associated Non-Coding RNAs.
LF356560 - JP 2014500723-A/164063: Polycomb-Associated Non-Coding RNAs.
LF356559 - JP 2014500723-A/164062: Polycomb-Associated Non-Coding RNAs.
LF356558 - JP 2014500723-A/164061: Polycomb-Associated Non-Coding RNAs.
CU674042 - Synthetic construct Homo sapiens gateway clone IMAGE:100020043 5' read GNL2 mRNA.
AK307352 - Homo sapiens cDNA, FLJ97300.
CU679273 - Synthetic construct Homo sapiens gateway clone IMAGE:100017472 5' read GNL2 mRNA.
LF356557 - JP 2014500723-A/164060: Polycomb-Associated Non-Coding RNAs.
LF356555 - JP 2014500723-A/164058: Polycomb-Associated Non-Coding RNAs.
LF356553 - JP 2014500723-A/164056: Polycomb-Associated Non-Coding RNAs.
LF356551 - JP 2014500723-A/164054: Polycomb-Associated Non-Coding RNAs.
LF356550 - JP 2014500723-A/164053: Polycomb-Associated Non-Coding RNAs.
MA442189 - JP 2018138019-A/14115: Polycomb-Associated Non-Coding RNAs.
MA442188 - JP 2018138019-A/14114: Polycomb-Associated Non-Coding RNAs.
MA592148 - JP 2018138019-A/164074: Polycomb-Associated Non-Coding RNAs.
MA592147 - JP 2018138019-A/164073: Polycomb-Associated Non-Coding RNAs.
MA592146 - JP 2018138019-A/164072: Polycomb-Associated Non-Coding RNAs.
MA592145 - JP 2018138019-A/164071: Polycomb-Associated Non-Coding RNAs.
MA592143 - JP 2018138019-A/164069: Polycomb-Associated Non-Coding RNAs.
MA592142 - JP 2018138019-A/164068: Polycomb-Associated Non-Coding RNAs.
MA592141 - JP 2018138019-A/164067: Polycomb-Associated Non-Coding RNAs.
MA592137 - JP 2018138019-A/164063: Polycomb-Associated Non-Coding RNAs.
MA592136 - JP 2018138019-A/164062: Polycomb-Associated Non-Coding RNAs.
MA592135 - JP 2018138019-A/164061: Polycomb-Associated Non-Coding RNAs.
MA592134 - JP 2018138019-A/164060: Polycomb-Associated Non-Coding RNAs.
MA592132 - JP 2018138019-A/164058: Polycomb-Associated Non-Coding RNAs.
MA592130 - JP 2018138019-A/164056: Polycomb-Associated Non-Coding RNAs.
MA592128 - JP 2018138019-A/164054: Polycomb-Associated Non-Coding RNAs.
MA592127 - JP 2018138019-A/164053: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NGP1, NM_013285, NOG2_HUMAN, NP_037417, Q13823, Q9BWN7
UCSC ID: uc001cbk.3
RefSeq Accession: NM_013285
Protein: Q13823 (aka NOG2_HUMAN)
CCDS: CCDS421.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_013285.2
exon count: 16CDS single in 3' UTR: no RNA size: 2419
ORF size: 2196CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4499.00frame shift in genome: no % Coverage: 99.30
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.