Human Gene GNL2 (uc001cbk.3)
Description: Homo sapiens guanine nucleotide binding protein-like 2 (nucleolar) (GNL2), mRNA.
Transcript (Including UTRs)
Position: hg19 chr1:38,032,413-38,061,586 Size: 29,174 Total Exon Count: 16 Strand: -
Coding Region
Position: hg19 chr1:38,032,456-38,061,423 Size: 28,968 Coding Exon Count: 16
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: NOG2_HUMAN
DESCRIPTION: RecName: Full=Nucleolar GTP-binding protein 2; AltName: Full=Autoantigen NGP-1;
FUNCTION: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity).SUBCELLULAR LOCATION: Nucleus, nucleolus.TISSUE SPECIFICITY: Ubiquitously expressed at relatively low levels in all human tissues tested, with the highest level of expression in the testes.SIMILARITY: Belongs to the MMR1/HSR1 GTP-binding protein family. NOG2 subfamily.SIMILARITY: Contains 1 G (guanine nucleotide-binding) domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR023179 - GTP-bd_ortho_bundle
IPR006073 - GTP_binding_domain
IPR024929 - NOG2
IPR012971 - NOG2_N_dom
Pfam Domains: PF01926 - 50S ribosome-binding GTPase
PF02421 - Ferrous iron transport protein B
PF08153 - NGP1NT (NUC091) domain
SCOP Domains: 52540 - P-loop containing nucleoside triphosphate hydrolases
ModBase Predicted Comparative 3D Structure on Q13823
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF206612 - JP 2014500723-A/14115: Polycomb-Associated Non-Coding RNAs.LF206611 - JP 2014500723-A/14114: Polycomb-Associated Non-Coding RNAs.LF356571 - JP 2014500723-A/164074: Polycomb-Associated Non-Coding RNAs.L05425 - Homo sapiens nucleolar GTPase mRNA, complete cds.BC000107 - Homo sapiens guanine nucleotide binding protein-like 2 (nucleolar), mRNA (cDNA clone MGC:1085 IMAGE:3506131), complete cds.AK130697 - Homo sapiens cDNA FLJ27187 fis, clone SYN02458.BC009250 - Homo sapiens guanine nucleotide binding protein-like 2 (nucleolar), mRNA (cDNA clone MGC:4453 IMAGE:2960125), complete cds.AK312915 - Homo sapiens cDNA, FLJ93364, Homo sapiens nucleolar GTPase (HUMAUANTIG), mRNA.DQ892183 - Synthetic construct clone IMAGE:100004813; FLH183784.01X; RZPDo839G07142D guanine nucleotide binding protein-like 2 (nucleolar) (GNL2) gene, encodes complete protein.KJ893704 - Synthetic construct Homo sapiens clone ccsbBroadEn_03098 GNL2 gene, encodes complete protein.KJ898738 - Synthetic construct Homo sapiens clone ccsbBroadEn_08132 GNL2 gene, encodes complete protein.EU176692 - Synthetic construct Homo sapiens clone IMAGE:100011467; FLH183783.01L; RZPDo839F04255D guanine nucleotide binding protein-like 2 (nucleolar) (GNL2) gene, encodes complete protein.LF356570 - JP 2014500723-A/164073: Polycomb-Associated Non-Coding RNAs.LF356569 - JP 2014500723-A/164072: Polycomb-Associated Non-Coding RNAs.LF356568 - JP 2014500723-A/164071: Polycomb-Associated Non-Coding RNAs.LF356566 - JP 2014500723-A/164069: Polycomb-Associated Non-Coding RNAs.LF356565 - JP 2014500723-A/164068: Polycomb-Associated Non-Coding RNAs.AK298358 - Homo sapiens cDNA FLJ54985 complete cds, highly similar to Nucleolar GTP-binding protein 2.LF356564 - JP 2014500723-A/164067: Polycomb-Associated Non-Coding RNAs.LF356560 - JP 2014500723-A/164063: Polycomb-Associated Non-Coding RNAs.LF356559 - JP 2014500723-A/164062: Polycomb-Associated Non-Coding RNAs.LF356558 - JP 2014500723-A/164061: Polycomb-Associated Non-Coding RNAs.CU674042 - Synthetic construct Homo sapiens gateway clone IMAGE:100020043 5' read GNL2 mRNA.AK307352 - Homo sapiens cDNA, FLJ97300.CU679273 - Synthetic construct Homo sapiens gateway clone IMAGE:100017472 5' read GNL2 mRNA.LF356557 - JP 2014500723-A/164060: Polycomb-Associated Non-Coding RNAs.LF356555 - JP 2014500723-A/164058: Polycomb-Associated Non-Coding RNAs.LF356553 - JP 2014500723-A/164056: Polycomb-Associated Non-Coding RNAs.LF356551 - JP 2014500723-A/164054: Polycomb-Associated Non-Coding RNAs.LF356550 - JP 2014500723-A/164053: Polycomb-Associated Non-Coding RNAs.MA442189 - JP 2018138019-A/14115: Polycomb-Associated Non-Coding RNAs.MA442188 - JP 2018138019-A/14114: Polycomb-Associated Non-Coding RNAs.MA592148 - JP 2018138019-A/164074: Polycomb-Associated Non-Coding RNAs.MA592147 - JP 2018138019-A/164073: Polycomb-Associated Non-Coding RNAs.MA592146 - JP 2018138019-A/164072: Polycomb-Associated Non-Coding RNAs.MA592145 - JP 2018138019-A/164071: Polycomb-Associated Non-Coding RNAs.MA592143 - JP 2018138019-A/164069: Polycomb-Associated Non-Coding RNAs.MA592142 - JP 2018138019-A/164068: Polycomb-Associated Non-Coding RNAs.MA592141 - JP 2018138019-A/164067: Polycomb-Associated Non-Coding RNAs.MA592137 - JP 2018138019-A/164063: Polycomb-Associated Non-Coding RNAs.MA592136 - JP 2018138019-A/164062: Polycomb-Associated Non-Coding RNAs.MA592135 - JP 2018138019-A/164061: Polycomb-Associated Non-Coding RNAs.MA592134 - JP 2018138019-A/164060: Polycomb-Associated Non-Coding RNAs.MA592132 - JP 2018138019-A/164058: Polycomb-Associated Non-Coding RNAs.MA592130 - JP 2018138019-A/164056: Polycomb-Associated Non-Coding RNAs.MA592128 - JP 2018138019-A/164054: Polycomb-Associated Non-Coding RNAs.MA592127 - JP 2018138019-A/164053: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: NGP1, NM_013285, NOG2_HUMAN, NP_037417, Q13823, Q9BWN7UCSC ID: uc001cbk.3RefSeq Accession: NM_013285
Protein: Q13823
(aka NOG2_HUMAN)
CCDS: CCDS421.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_013285.2
exon count:
16 CDS single in 3' UTR:
no
RNA size:
2419
ORF size:
2196 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
4499.00 frame shift in genome:
no
% Coverage:
99.30
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.