Description: Homo sapiens chemokine (C-X-C motif) ligand 14 (CXCL14), mRNA. RefSeq Summary (NM_004887): This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. CCDS Note: This CCDS representation uses the 5'-most in-frame start codon, which is conserved in higher primates. An alternative downstream start codon, which is more widely conserved and has a stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 12 aa shorter at the N-terminus. Both the longer and shorter proteins have N-terminal signal peptides, as predicted by SignalP 3.0. There is no experimental evidence showing which start codon is preferentially used in vivo. Transcript (Including UTRs) Position: hg19 chr5:134,906,371-134,914,969 Size: 8,599 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr5:134,907,543-134,914,504 Size: 6,962 Coding Exon Count: 4
ID:CXL14_HUMAN DESCRIPTION: RecName: Full=C-X-C motif chemokine 14; AltName: Full=Chemokine BRAK; AltName: Full=MIP-2G; AltName: Full=Small-inducible cytokine B14; Flags: Precursor; FUNCTION: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte- derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes. INDUCTION: Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS). DOMAIN: The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway. PTM: Ubiquitinated, followed by degradation by the proteasome. SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family. CAUTION: It is uncertain whether Met-1 or Met-13 is the initiator. SEQUENCE CAUTION: Sequence=AAD38944.1; Type=Erroneous initiation; WEB RESOURCE: Name=Wikipedia; Note=CXCL14 entry; URL="http://en.wikipedia.org/wiki/CXCL14";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95715
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
