Human Gene CDK18 (uc001hcr.3)
Description: Homo sapiens cyclin-dependent kinase 18 (CDK18), transcript variant 1, mRNA.
Transcript (Including UTRs)
Position: hg19 chr1:205,473,684-205,501,921 Size: 28,238 Total Exon Count: 16 Strand: +
Coding Region
Position: hg19 chr1:205,492,296-205,500,506 Size: 8,211 Coding Exon Count: 15
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
PF14531 - Kinase-like
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q07002-3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AK293756 - Homo sapiens cDNA FLJ56472 complete cds, highly similar to Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22).AK296320 - Homo sapiens cDNA FLJ53597 complete cds, highly similar to Homo sapiens PCTAIRE protein kinase 3 (PCTK3), transcript variant 1, mRNA.AK295654 - Homo sapiens cDNA FLJ55877 complete cds.JD402430 - Sequence 383454 from Patent EP1572962.AY353237 - Homo sapiens PCTAIRE protein kinase 3 isoform a (PCTK3) mRNA, complete cds, alternatively spliced.JD519411 - Sequence 500435 from Patent EP1572962.JD393998 - Sequence 375022 from Patent EP1572962.JD402309 - Sequence 383333 from Patent EP1572962.AY353240 - Homo sapiens PCTAIRE protein kinase 3 (PCTK3) mRNA, 5' UTR, alternatively spliced.JD253739 - Sequence 234763 from Patent EP1572962.AY353238 - Homo sapiens PCTAIRE protein kinase 3 isoform b (PCTK3) mRNA, complete cds, alternatively spliced.BC011526 - Homo sapiens PCTAIRE protein kinase 3, mRNA (cDNA clone MGC:9361 IMAGE:3855304), complete cds.JD527085 - Sequence 508109 from Patent EP1572962.JD246597 - Sequence 227621 from Patent EP1572962.AY353239 - Homo sapiens PCTAIRE protein kinase 3-like protein (PCTK3) mRNA, partial sequence, alternatively spliced.AK126879 - Homo sapiens cDNA FLJ44931 fis, clone BRAMY3015799, highly similar to Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22).AB209307 - Homo sapiens mRNA for PCTAIRE protein kinase 3 isoform b variant protein.AB527878 - Synthetic construct DNA, clone: pF1KB0449, Homo sapiens PCTK3 gene for PCTAIRE protein kinase 3, without stop codon, in Flexi system.DQ893540 - Synthetic construct clone IMAGE:100006170; FLH164194.01X; RZPDo839D09162D PCTAIRE protein kinase 3 (PCTK3) gene, encodes complete protein.DQ893749 - Synthetic construct Homo sapiens clone IMAGE:100008209; FLH164190.01L; RZPDo839D09161D PCTAIRE protein kinase 3 (PCTK3) gene, encodes complete protein.KJ901046 - Synthetic construct Homo sapiens clone ccsbBroadEn_10440 CDK18 gene, encodes complete protein.KJ905249 - Synthetic construct Homo sapiens clone ccsbBroadEn_14732 CDK18 gene, encodes complete protein.BT007299 - Homo sapiens PCTAIRE-motif protein kinase 3 mRNA, complete cds.AK308913 - Homo sapiens cDNA, FLJ98954.AK295272 - Homo sapiens cDNA FLJ55785 complete cds, highly similar to Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22).X66362 - H.sapiens mRNA PCTAIRE-3 for serine/threonine protein kinase.BC000281 - Homo sapiens PCTAIRE protein kinase 3, mRNA (cDNA clone IMAGE:3357514), partial cds.BC040529 - Homo sapiens PCTAIRE protein kinase 3, mRNA (cDNA clone IMAGE:5259725), complete cds.AL161977 - Homo sapiens mRNA; cDNA DKFZp761L1515 (from clone DKFZp761L1515).JD208959 - Sequence 189983 from Patent EP1572962.JD443801 - Sequence 424825 from Patent EP1572962.JD428672 - Sequence 409696 from Patent EP1572962.BC009223 - Homo sapiens PCTAIRE protein kinase 3, mRNA (cDNA clone IMAGE:3928693), partial cds.JD126719 - Sequence 107743 from Patent EP1572962.JD196540 - Sequence 177564 from Patent EP1572962.JD235490 - Sequence 216514 from Patent EP1572962.JD411569 - Sequence 392593 from Patent EP1572962.JD148527 - Sequence 129551 from Patent EP1572962.JD475748 - Sequence 456772 from Patent EP1572962.JD190295 - Sequence 171319 from Patent EP1572962.JD416187 - Sequence 397211 from Patent EP1572962.JD479002 - Sequence 460026 from Patent EP1572962.JD522700 - Sequence 503724 from Patent EP1572962.JD153172 - Sequence 134196 from Patent EP1572962.JD372174 - Sequence 353198 from Patent EP1572962.JD104592 - Sequence 85616 from Patent EP1572962.JD137651 - Sequence 118675 from Patent EP1572962.JD364984 - Sequence 346008 from Patent EP1572962.JD442424 - Sequence 423448 from Patent EP1572962.JD444993 - Sequence 426017 from Patent EP1572962.JD107819 - Sequence 88843 from Patent EP1572962.JD155257 - Sequence 136281 from Patent EP1572962.JD107140 - Sequence 88164 from Patent EP1572962.JD191143 - Sequence 172167 from Patent EP1572962.JD157128 - Sequence 138152 from Patent EP1572962.JD131827 - Sequence 112851 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: NM_212503, NP_997668, PCTK3, Q07002-3UCSC ID: uc001hcr.3RefSeq Accession: NM_212503
Protein: Q07002-3 , splice isoform of Q07002
CCDS: CCDS1454.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_212503.2
exon count:
16 CDS single in 3' UTR:
no
RNA size:
3212
ORF size:
1515 CDS single in intron:
no
Alignment % ID:
99.97
txCdsPredict score:
3099.00 frame shift in genome:
no
% Coverage:
99.38
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.