Human Gene CDK18 (uc001hcr.3)
  Description: Homo sapiens cyclin-dependent kinase 18 (CDK18), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:205,473,684-205,501,921 Size: 28,238 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg19 chr1:205,492,296-205,500,506 Size: 8,211 Coding Exon Count: 15 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:205,473,684-205,501,921)mRNA (may differ from genome)Protein (504 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
OMIMPubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 120.76 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 568.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -83.60262-0.319 Picture PostScript Text
3' UTR -592.761415-0.419 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
PF14531 - Kinase-like

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q07002-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AK293756 - Homo sapiens cDNA FLJ56472 complete cds, highly similar to Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22).
AK296320 - Homo sapiens cDNA FLJ53597 complete cds, highly similar to Homo sapiens PCTAIRE protein kinase 3 (PCTK3), transcript variant 1, mRNA.
AK295654 - Homo sapiens cDNA FLJ55877 complete cds.
JD402430 - Sequence 383454 from Patent EP1572962.
AY353237 - Homo sapiens PCTAIRE protein kinase 3 isoform a (PCTK3) mRNA, complete cds, alternatively spliced.
JD519411 - Sequence 500435 from Patent EP1572962.
JD393998 - Sequence 375022 from Patent EP1572962.
JD402309 - Sequence 383333 from Patent EP1572962.
AY353240 - Homo sapiens PCTAIRE protein kinase 3 (PCTK3) mRNA, 5' UTR, alternatively spliced.
JD253739 - Sequence 234763 from Patent EP1572962.
AY353238 - Homo sapiens PCTAIRE protein kinase 3 isoform b (PCTK3) mRNA, complete cds, alternatively spliced.
BC011526 - Homo sapiens PCTAIRE protein kinase 3, mRNA (cDNA clone MGC:9361 IMAGE:3855304), complete cds.
JD527085 - Sequence 508109 from Patent EP1572962.
JD246597 - Sequence 227621 from Patent EP1572962.
AY353239 - Homo sapiens PCTAIRE protein kinase 3-like protein (PCTK3) mRNA, partial sequence, alternatively spliced.
AK126879 - Homo sapiens cDNA FLJ44931 fis, clone BRAMY3015799, highly similar to Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22).
AB209307 - Homo sapiens mRNA for PCTAIRE protein kinase 3 isoform b variant protein.
AB527878 - Synthetic construct DNA, clone: pF1KB0449, Homo sapiens PCTK3 gene for PCTAIRE protein kinase 3, without stop codon, in Flexi system.
DQ893540 - Synthetic construct clone IMAGE:100006170; FLH164194.01X; RZPDo839D09162D PCTAIRE protein kinase 3 (PCTK3) gene, encodes complete protein.
DQ893749 - Synthetic construct Homo sapiens clone IMAGE:100008209; FLH164190.01L; RZPDo839D09161D PCTAIRE protein kinase 3 (PCTK3) gene, encodes complete protein.
KJ901046 - Synthetic construct Homo sapiens clone ccsbBroadEn_10440 CDK18 gene, encodes complete protein.
KJ905249 - Synthetic construct Homo sapiens clone ccsbBroadEn_14732 CDK18 gene, encodes complete protein.
BT007299 - Homo sapiens PCTAIRE-motif protein kinase 3 mRNA, complete cds.
AK308913 - Homo sapiens cDNA, FLJ98954.
AK295272 - Homo sapiens cDNA FLJ55785 complete cds, highly similar to Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22).
X66362 - H.sapiens mRNA PCTAIRE-3 for serine/threonine protein kinase.
BC000281 - Homo sapiens PCTAIRE protein kinase 3, mRNA (cDNA clone IMAGE:3357514), partial cds.
BC040529 - Homo sapiens PCTAIRE protein kinase 3, mRNA (cDNA clone IMAGE:5259725), complete cds.
AL161977 - Homo sapiens mRNA; cDNA DKFZp761L1515 (from clone DKFZp761L1515).
JD208959 - Sequence 189983 from Patent EP1572962.
JD443801 - Sequence 424825 from Patent EP1572962.
JD428672 - Sequence 409696 from Patent EP1572962.
BC009223 - Homo sapiens PCTAIRE protein kinase 3, mRNA (cDNA clone IMAGE:3928693), partial cds.
JD126719 - Sequence 107743 from Patent EP1572962.
JD196540 - Sequence 177564 from Patent EP1572962.
JD235490 - Sequence 216514 from Patent EP1572962.
JD411569 - Sequence 392593 from Patent EP1572962.
JD148527 - Sequence 129551 from Patent EP1572962.
JD475748 - Sequence 456772 from Patent EP1572962.
JD190295 - Sequence 171319 from Patent EP1572962.
JD416187 - Sequence 397211 from Patent EP1572962.
JD479002 - Sequence 460026 from Patent EP1572962.
JD522700 - Sequence 503724 from Patent EP1572962.
JD153172 - Sequence 134196 from Patent EP1572962.
JD372174 - Sequence 353198 from Patent EP1572962.
JD104592 - Sequence 85616 from Patent EP1572962.
JD137651 - Sequence 118675 from Patent EP1572962.
JD364984 - Sequence 346008 from Patent EP1572962.
JD442424 - Sequence 423448 from Patent EP1572962.
JD444993 - Sequence 426017 from Patent EP1572962.
JD107819 - Sequence 88843 from Patent EP1572962.
JD155257 - Sequence 136281 from Patent EP1572962.
JD107140 - Sequence 88164 from Patent EP1572962.
JD191143 - Sequence 172167 from Patent EP1572962.
JD157128 - Sequence 138152 from Patent EP1572962.
JD131827 - Sequence 112851 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_212503, NP_997668, PCTK3, Q07002-3
UCSC ID: uc001hcr.3
RefSeq Accession: NM_212503
Protein: Q07002-3, splice isoform of Q07002 CCDS: CCDS1454.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_212503.2
exon count: 16CDS single in 3' UTR: no RNA size: 3212
ORF size: 1515CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 3099.00frame shift in genome: no % Coverage: 99.38
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.