Description: Homo sapiens calmodulin 3 (phosphorylase kinase, delta) (CALM3), mRNA. RefSeq Summary (NM_005184): This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]. Transcript (Including UTRs) Position: hg19 chr19:47,104,512-47,114,039 Size: 9,528 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr19:47,104,692-47,112,410 Size: 7,719 Coding Exon Count: 6
ID:CALM_HUMAN DESCRIPTION: RecName: Full=Calmodulin; Short=CaM; FUNCTION: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. SUBUNIT: Interacts with MYO1C and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CEP110, TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2. Interacts with FCHO1. INTERACTION: P29274:ADORA2A; NbExp=3; IntAct=EBI-397435, EBI-2902702; P49407:ARRB1; NbExp=3; IntAct=EBI-397435, EBI-743313; P32121:ARRB2; NbExp=3; IntAct=EBI-397435, EBI-714559; Q13936:CACNA1C; NbExp=2; IntAct=EBI-397435, EBI-1038838; O43303:CCP110; NbExp=9; IntAct=EBI-397435, EBI-1566217; P40136:cya (xeno); NbExp=8; IntAct=EBI-397435, EBI-457011; P00533:EGFR; NbExp=3; IntAct=EBI-397435, EBI-297353; P25445:FAS; NbExp=4; IntAct=EBI-397435, EBI-494743; O95259:KCNH1; NbExp=2; IntAct=EBI-397435, EBI-2909270; P26645:Marcks (xeno); NbExp=2; IntAct=EBI-397435, EBI-911805; Q14524:SCN5A; NbExp=2; IntAct=EBI-397435, EBI-726858; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. PTM: Ubiquitination results in a strongly decreased activity (By similarity). PTM: Phosphorylation results in a decreased activity (By similarity). MISCELLANEOUS: This protein has four functional calcium-binding sites. SIMILARITY: Belongs to the calmodulin family. SIMILARITY: Contains 4 EF-hand domains. SEQUENCE CAUTION: Sequence=CAA36839.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Protein Spotlight; Note=A question of length - Issue 105 of May 2009; URL="http://web.expasy.org/spotlight/back_issues/sptlt105.shtml";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00036 - EF hand PF08726 - Ca2+ insensitive EF hand PF12763 - Cytoskeletal-regulatory complex EF hand PF13202 - EF hand PF13405 - EF-hand domain PF13499 - EF-hand domain pair PF13833 - EF-hand domain pair PF14658 - EF-hand domain
ModBase Predicted Comparative 3D Structure on P62158
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells h_pgc1aPathway - Regulation of PGC-1a h_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation h_nos1Pathway - Nitric Oxide Signaling Pathway h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling h_CaCaMPathway - Ca++/ Calmodulin-dependent Protein Kinase Activation h_bcrPathway - BCR Signaling Pathway h_gpcrPathway - Signaling Pathway from G-Protein Families h_tcrPathway - T Cell Receptor Signaling Pathway h_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin h_Ccr5Pathway - Pertussis toxin-insensitive CCR5 Signaling in Macrophage h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells h_gcrPathway - Corticosteroids and cardioprotection h_mef2dPathway - Role of MEF2D in T-cell Apoptosis h_no1Pathway - Actions of Nitric Oxide in the Heart h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells h_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) h_pyk2Pathway - Links between Pyk2 and Map Kinases